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ATP4A
Anti-ATP4A Recombinant Antibody Products
- Recombinant Anti-Human ATP4A Antibody (MOB-2967z)
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- Derivation: Mouse
- Species Reactivity: Human
- Type: IgG
- Application: ELISA, WB, IP, FuncS
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- Recombinant Anti-Human ATP4A Antibody Fab Fragment (MOB-2967z-F(E))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Fab
- Application: IF, WB, FuncS
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- Recombinant Anti-Human ATP4A Antibody scFv Fragment (MOB-2967z-S(P))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: scFv
- Application: IP, IF, Biosensors, FuncS
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For Research Use Only. Not For Clinical Use.
The protein encoded by this gene belongs to a family of P-type cation-transporting ATPases. The gastric H+, K+-ATPase is a heterodimer consisting of a high molecular weight catalytic alpha subunit and a smaller but heavily glycosylated beta subunit. This enzyme is a proton pump that catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. It is also responsible for gastric acid secretion. This gene encodes a catalytic alpha subunit of the gastric H+, K+-ATPase.
Protein class
Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins, Transporters
Predicted location
Membrane
Single cell type specificity
Group enriched (Gastric mucus-secreting cells, Late spermatids)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Not detected
Interaction
The gastric H(+)/K(+) ATPase pump is composed of the catalytic alpha subunit ATP4A and the regulatory beta subunit ATP4B. Interacts (via the P-domain) with ATP4B (via N-terminus); this interaction stabilizes the lumenal-open E2 conformation state and prevents the reverse reaction of the transport cycle.
Molecular function
Translocase
More Types Infomation
Related Signaling Pathways
cAMP Signaling Pathway
Related Diseases
Morphine Addiction