Acetyl-Histone H3-K23

This gene encodes a core component of the nucleosome. Nucleosomes are fundamental structures that wrap and compact DNA into chromatin, which in turn restricts DNA accessibility for cellular machinery requiring DNA as a template. Thus, histones are central to critical processes such as transcription regulation, DNA repair, DNA replication, and chromosomal stability. DNA accessibility is finely controlled through a complex array of post-translational histone modifications, often referred to as the "histone code," and through nucleosome remodeling. This specific gene is intronless and encodes a replication-dependent histone, a member of the histone H3 family. Its transcripts lack polyA tails, instead containing a characteristic palindromic termination element. Notably, this gene is located separately from other H3 genes, which typically reside within the histone gene cluster on chromosome 6p22-p21.3.