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CCNT1
Anti-CCNT1 Recombinant Antibody Products
- Recombinant Anti-human CCNT1 Intrabody [(D-Arg)9] (IAB-B032(A))
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- Species Reactivity: human
- Type: scFv-(D-Arg)9
- Application: FACS, ELISA, IF, FuncS
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- Recombinant Anti-human CCNT1 Intrabody [+36 GFP] (IAB-B032(G))
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- Species Reactivity: human
- Type: scFv-(+36GFP)
- Application: FACS, ICC, FuncS
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- Recombinant Anti-human CCNT1 Intrabody [Tat] (IAB-B032(T))
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- Species Reactivity: human
- Type: scFv-Tat
- Application: ELISA, ICC, FuncS
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For Research Use Only. Not For Clinical Use.
This gene encodes a member of the highly conserved cyclin C subfamily. The encoded protein tightly associates with cyclin-dependent kinase 9, and is a major subunit of positive transcription elongation factor b (p-TEFb). In humans, there are multiple forms of positive transcription elongation factor b, which may include one of several different cyclins along with cyclin-dependent kinase 9. The complex containing the encoded cyclin and cyclin-dependent kinase 9 acts as a cofactor of human immunodeficiency virus type 1 (HIV-1) Tat protein, and is both necessary and sufficient for full activation of viral transcription. This cyclin and its kinase partner are also involved in triggering transcript elongation through phosphorylation of the carboxy-terminal domain of the largest RNA polymerase II subunit. Overexpression of this gene is implicated in tumor growth. Alternative splicing results in multiple transcript variants.
Protein class
Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Early spermatids)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Cyclin-T1 is the predominant cyclin that associates with CDK9 to form a heterodimer called P-TEFb. P-TEFb forms a complex with AFF4/AF5Q31. Component of a complex which is at least composed of HTATSF1/Tat-SF1, P-TEFb complex, RNA pol II, SUPT5H, and NCL/nucleolin (PubMed:10393184). Component of the 7SK snRNP complex at least composed of P-TEFb (composed of CDK9 and CCNT1/cyclin-T1), HEXIM1, HEXIM2, BCDIN3, SART3 proteins and 7SK and U6 snRNAs (PubMed:17643375). Interacts with BRD4, targets chromatin binding (PubMed:16109376, PubMed:16109377, PubMed:24360279). Interacts with JMJD6 (PubMed:24360279). Interacts with MDFIC (PubMed:12944466). Interacts with HSF1 (PubMed:27189267). Interacts with HTATSF1 (PubMed:10913173). Interacts with AFF4 (PubMed:12065898). Interacts with TBX21 (PubMed:27292648). (Microbial infection) Interacts with the transactivation region of HIV-1, HIV-2 and SIV Tat.
Molecular function
Cyclin
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