CD19 & FcαR

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Anti-CD19 & FcαR Products

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    • Target: CD19
    • Linker: SPDB (N-succinimidyl 4-(2-pyridyldithio)butyrate)
    • Drug: DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
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    • Target: CD19
    • Linker: SMCC (4-[N-maleimidomethyl] cyclohexane-1 carboxylhydrazide).
    • Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
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    • Target: CD19
    • Linker: SPP (N-succinimidyl-4-(2-pyridyldithio)pentanoate)
    • Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
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    • Target: CD19
    • Linker: MCC (Maleimidomethyl cyclohexane-1-carboxylate)
    • Drug: DM1 (N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
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Background

This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene.
CD19: Encodes a B-cell surface receptor involved in antigen signaling. It amplifies B-cell receptor signals to regulate proliferation and differentiation. The protein is essential for humoral immunity. Mutations cause immunodeficiency.
CD19 & FcαR
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