+ Filter
Loading...
CDH5
Anti-CDH5 Recombinant Antibody Products
CompareCan't find the products you're looking for? Try to filter in the left sidebar.Filter By Tag
More Infomation
Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us
For Research Use Only. Not For Clinical Use.
CDH5, also known as VE-cadherin, is a type of cadherin protein expressed primarily on endothelial cells. It plays a key role in the formation and maintenance of endothelial cell junctions, which are critical for vascular integrity. CDH5 regulates cell-cell adhesion within the endothelial layer and is involved in angiogenesis, the process of new blood vessel formation. This protein helps maintain the blood-brain barrier and regulates vascular permeability, playing a role in tissue homeostasis and inflammation. Dysregulation of CDH5 has been implicated in various vascular diseases, including atherosclerosis and cancer metastasis.
Protein class
Cancer-related genes, CD markers, Plasma proteins
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (Adipocytes, Endothelial cells, Hepatic stellate cells, Late spermatids, Syncytiotrophoblasts)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Group enriched (HUVEC TERT2, TIME)
Interaction
Interacts (via cadherin 5 domain) with PTPRB (By similarity). Interacts with TRPC4 (PubMed:19996314). Interacts with KRIT1 (PubMed:20332120). Interacts with PARD3 (By similarity). Interacts with RTN4 (isoform B) (PubMed:21183689). Interacts with PALS1; the interaction promotes PALS1 localization to cell junctions and is required for CDH5-mediated vascular lumen formation and endothelial cell (PubMed:27466317).
More Types Infomation