CREB1

Antibody Magnetic Beads AbPlus Recombinant Antibody Products Formats

Anti-CREB1 Recombinant Antibody Products

AbPlus™ Anti-CREB1 Magnetic Beads (CBACN-159) (VS-0424-XY69)
- Target: CREB1
- Target Species: Human, Mouse, Rat, Zebrafish
- Application: IP, Protein Purification
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AbPlus™ Anti-CREB1 Magnetic Beads (VS-0724-YC812) (VS-0724-YC812)
- Target: CREB1
- Target Species: Human
- Application: IP, Protein Purification
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For Research Use Only. Not For Clinical Use.

CREB1 (CAMP Responsive Element Binding Protein 1) is a Protein Coding gene. Diseases associated with CREB1 include Histiocytoma, Angiomatoid Fibrous and Melanoma Of Soft Tissue. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and DAG and IP3 signaling. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and enzyme binding. An important paralog of this gene is CREM.

Protein class

Cancer-related genes, Disease related genes, Transcription factors

Predicted location

Intracellular

Single cell type specificity

Cell type enriched (Early spermatids)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Low cell line specificity

Interaction

Interacts with PPRC1. Binds DNA as a dimer. This dimer is stabilized by magnesium ions. Interacts, through the bZIP domain, with the coactivators TORC1/CRTC1, TORC2/CRTC2 and TORC3/CRTC3. When phosphorylated on Ser-119, binds CREBBP (By similarity). Interacts with CREBL2; regulates CREB1 phosphorylation, stability and transcriptional activity (By similarity). Interacts (phosphorylated form) with TOX3. Interacts with ARRB1. Binds to HIPK2. Interacts with SGK1. Interacts with TSSK4; this interaction facilitates phosphorylation on Ser-119 (PubMed:15964553). Forms a complex with KMT2A and CREBBP (PubMed:23651431). (Microbial infection) Interacts with hepatitis B virus/HBV protein X. (Microbial infection) Interacts with HTLV-1 protein Tax.

Molecular function

Activator, DNA-binding

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Related Signaling Pathways

cAMP Signaling Pathway