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FGFR2

Engineered Antibody Antibody-like Scaffold Protein
The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009]
FGFR2
Protein class

Cancer-related genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, RAS pathway related proteins

Predicted location

Intracellular, Membrane, Secreted (different isoforms)

Single cell type specificity

Group enriched (Oligodendrocytes, Astrocytes, Cholangiocytes)

Immune cell specificity

Group enriched (basophil, eosinophil)

Cell line specificity

Cell line enhanced (AN3-CA, BEWO, CACO-2, HaCaT, HAP1, NTERA-2, T-47d)

Interaction

Monomer. Homodimer after ligand binding. Interacts predominantly with FGF1 and FGF2, but can also interact with FGF3, FGF4, FGF6, FGF7, FGF8, FGF9, FGF10, FGF17, FGF18 and FGF22 (in vitro). Ligand specificity is determined by tissue-specific expression of isoforms, and differences in the third Ig-like domain are crucial for ligand specificity. Isoform 1 has high affinity for FGF1 and FGF2, but low affinity for FGF7. Isoform 3 has high affinity for FGF1 and FGF7, and has much higher affinity for FGF7 than isoform 1 (in vitro). Affinity for fibroblast growth factors (FGFs) is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Likewise, KLB increases the affinity for FGF19 and FGF21. Interacts with PLCG1, GRB2 and PAK4. Interacts with FLRT2 (By similarity).

Molecular function

Heparin-binding, Kinase, Receptor, Transferase, Tyrosine-protein kinase

More Types Infomation
Related Diseases
EGFR Tyrosine Kinase Inhibitor Resistance EGFR Tyrosine Kinase Inhibitor Resistance
  • Anti-FGFR2 (clone 12425)-SPDB-DM4 ADC (ADC-091CL)
    • Target: FGFR2
    • Linker: SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate)
    • Drug: DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
    Go to compare Compare
  • Anti-FGFR2 (clone 12422)-SPDB-DM4 ADC (ADC-090CL)
    • Target: FGFR2
    • Linker: SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate)
    • Drug: DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
    Go to compare Compare
  • Anti-FGFR2 (clone 11723)-sulfo-SMCC-DM1 ADC (ADC-089CL)
    • Target: FGFR2
    • Linker: sulfo-SMCC (sulfosuccinimidyl 4-(N-maleimidomethyl) cyclohexane-l-carbox late)
    • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
    Go to compare Compare
  • Anti-FGFR2 (clone 11725)-sulfo-SMCC-DM1 ADC (ADC-088CL)
    • Target: FGFR2
    • Linker: sulfo-SMCC (sulfosuccinimidyl 4-(N-maleimidomethyl) cyclohexane-l-carbox late)
    • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
    Go to compare Compare
  • Anti-FGFR2 (clone 10846)-sulfo-SMCC-DM1 ADC (ADC-087CL)
    • Target: FGFR2
    • Linker: sulfo-SMCC (sulfosuccinimidyl 4-(N-maleimidomethyl) cyclohexane-l-carbox late)
    • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
    Go to compare Compare
  • Anti-FGFR2 (clone 12439)-sulfo-SMCC-DM1 ADC (ADC-086CL)
    • Target: FGFR2
    • Linker: sulfo-SMCC (sulfosuccinimidyl 4-(N-maleimidomethyl) cyclohexane-l-carbox late)
    • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
    Go to compare Compare
  • Anti-FGFR2 (clone 12944)-sulfo-SMCC-DM1 ADC (ADC-085CL)
    • Target: FGFR2
    • Linker: sulfo-SMCC (sulfosuccinimidyl 4-(N-maleimidomethyl) cyclohexane-l-carbox late)
    • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
    Go to compare Compare
  • Anti-FGFR2 (clone 12931)-sulfo-SMCC-DM1 ADC (ADC-084CL)
    • Target: FGFR2
    • Linker: sulfo-SMCC (sulfosuccinimidyl 4-(N-maleimidomethyl) cyclohexane-l-carbox late)
    • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
    Go to compare Compare
  • Anti-FGFR2 (clone 12947)-sulfo-SMCC-DM1 ADC (ADC-083CL)
    • Target: FGFR2
    • Linker: sulfo-SMCC (sulfosuccinimidyl 4-(N-maleimidomethyl) cyclohexane-l-carbox late)
    • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
    Go to compare Compare
  • Anti-FGFR2 (clone 12422)-sulfo-SMCC-DM1 ADC (ADC-082CL)
    • Target: FGFR2
    • Linker: sulfo-SMCC (sulfosuccinimidyl 4-(N-maleimidomethyl) cyclohexane-l-carbox late)
    • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
    Go to compare Compare
  • Anti-FGFR2 (clone 11722)-sulfo-SMCC-DM1 ADC (ADC-081CL)
    • Target: FGFR2
    • Linker: sulfo-SMCC (sulfosuccinimidyl 4-(N-maleimidomethyl) cyclohexane-l-carbox late)
    • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
    Go to compare Compare
  • Anti-FGFR2 (clone 10923)-sulfo-SMCC-DM1 ADC (ADC-080CL)
    • Target: FGFR2
    • Linker: sulfo-SMCC (sulfosuccinimidyl 4-(N-maleimidomethyl) cyclohexane-l-carbox late)
    • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
    Go to compare Compare
  • Anti-FGFR2 (clone 10918)-sulfo-SMCC-DM1 ADC (ADC-079CL)
    • Target: FGFR2
    • Linker: sulfo-SMCC (sulfosuccinimidyl 4-(N-maleimidomethyl) cyclohexane-l-carbox late)
    • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
    Go to compare Compare
  • Anti-FGFR2 (clone 10220)-sulfo-SMCC-DM1 ADC (ADC-078CL)
    • Target: FGFR2
    • Linker: sulfo-SMCC (sulfosuccinimidyl 4-(N-maleimidomethyl) cyclohexane-l-carbox late)
    • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
    Go to compare Compare
  • Anti-FGFR2 (clone 10164)-sulfo-SMCC-DM1 ADC (ADC-077CL)
    • Target: FGFR2
    • Linker: sulfo-SMCC (sulfosuccinimidyl 4-(N-maleimidomethyl) cyclohexane-l-carbox late)
    • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
    Go to compare Compare
  • Anti-FGFR2 (clone 12433)-sulfo-SMCC-DM1 ADC (ADC-076CL)
    • Target: FGFR2
    • Linker: sulfo-SMCC (sulfosuccinimidyl 4-(N-maleimidomethyl) cyclohexane-l-carbox late)
    • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
    Go to compare Compare
  • Anti-FGFR2 (clone 12425)-sulfo-SMCC-DM1 ADC (ADC-075CL)
    • Target: FGFR2
    • Linker: sulfo-SMCC (sulfosuccinimidyl 4-(N-maleimidomethyl) cyclohexane-l-carbox late)
    • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
    Go to compare Compare
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