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GRIN1

Recombinant Antibody Products Formats

Anti-GRIN1 Recombinant Antibody Products

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For Research Use Only. Not For Clinical Use.


Enables several functions, including calmodulin binding activity; cation binding activity; and ion channel activity. Involved in propylene metabolic process. Acts upstream of or within several processes, including chemical synaptic transmission; learning or memory; and regulation of neuron projection development. Located in several cellular components, including dendritic spine; postsynaptic density membrane; and synaptic vesicle membrane. Is integral component of postsynaptic density membrane. Part of NMDA selective glutamate receptor complex. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; sensory organ; and skeleton. Used to study autism spectrum disorder and schizophrenia. Human ortholog(s) of this gene implicated in alcohol use disorder; autosomal dominant non-syndromic intellectual disability 8; and cerebral infarction. Orthologous to human GRIN1 (glutamate ionotropic receptor NMDA type subunit 1).
Protein class

Disease related genes, FDA approved drug targets, Human disease related genes, Plasma proteins, RAS pathway related proteins, Transporters

Predicted location

Membrane

Single cell type specificity

Group enriched (Inhibitory neurons, Excitatory neurons)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (OE19, REH, RPMI-8226, SCLC-21H, SH-SY5Y, T-47d)

Interaction

Heterotetramer. Forms heterotetrameric channels composed of two zeta subunits (GRIN1), and two epsilon subunits (GRIN2A, GRIN2B, GRIN2C or GRIN2D) (in vitro) (PubMed:7685113, PubMed:28126851, PubMed:26919761, PubMed:26875626, PubMed:28105280). Can also form heterotetrameric channels that contain at least one zeta subunit (GRIN1), an epsilon subunit, plus GRIN3A or GRIN3B (in vitro). In vivo, the subunit composition may vary in function of the expression levels of the different subunits. Found in a complex with GRIN2A or GRIN2B, GRIN3A and PPP2CB (By similarity). Found in a complex with GRIN2A or GRIN2B and GRIN3B (By similarity). Interacts with SNX27 (via PDZ domain); the interaction is required for recycling to the plasma membrane when endocytosed and prevent degradation in lysosomes (By similarity). Interacts with DLG4 and MPDZ. Interacts with LRFN1 and LRFN2 (By similarity). Interacts with MYZAP (PubMed:18849881). Found in a complex with DLG4 and PRR7 (By similarity). Found in a complex with GRIN2B and PRR7 (PubMed:27458189). Interacts with PRR7; the interaction is reduced following NMDA receptor activity (PubMed:27458189).

Molecular function

Ion channel, Ligand-gated ion channel, Receptor

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