Recombinant Rabbit Anti-GRIN1 Detection Antibody (clone R84-4W-8) (CAT#: VS3-WK1891)
This antibody is a rabbit recombinant antibody against mouse GRIN1. It was developed by immunization of rabbit with recombinant mouse GRIN1 protein and then was produced as a recombinant antibody. The isotype of this product is rabbit IgG. R14-6Y-3 and R84-4W-8 were identified as antibody pair for sandwich ELISA. As a detection antibody, the clone R84-4W-8 can be used in ELISA analysis to identify mouse GRIN1.
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Normal Tissue
RNA Expression
Figure 1 High expression in hippocampal formation
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/67773/168000_B_9_6_selected.jpg
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/67773/168000_B_9_6_selected.jpg
Figure 2 Low expression in tonsil
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/67773/168000_A_4_8_val_selected.jpg
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/67773/168000_A_4_8_val_selected.jpg
Figure 3 Cerebral cortex
(Neuronal cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/67773/168000_B_8_5.jpg
(Neuronal cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/67773/168000_B_8_5.jpg
Figure 4 Testis
(Cells in seminiferous ducts Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear Leydig cells Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/67773/168000_A_6_6.jpg
(Cells in seminiferous ducts Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear Leydig cells Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/67773/168000_A_6_6.jpg
Figure 5 RNA cell line category: Cell line enhanced (OE19, REH, RPMI-8226, SCLC-21H, SH-SY5Y, T-47d)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000176884-GRIN1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000176884-GRIN1
Specifications
- Immunogen
- Recombinant mouse GRIN1 protein
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Mouse GRIN1
- Species Reactivity
- Mouse
- Clone
- R84-4W-8
- Applications
- ELISA
- Conjugate
- Unconjugated
Product Property
- Clonality
- Monoclonal
- Purification
- Protein A affinity purified
- Purity
- >95% as determined by SDS-PAGE
- Aggregation
- < 5%
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- 0.01M PBS, pH 7.2
- Storage
- Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- NR1; GluN1; Nmdar; NMD-R1; NMDAR1; M100174; Rgsc174; GluRzeta1; GluRdelta1
- Gene ID
- 14810
- UniProt ID
- P35438
- Long Name
- Glutamate receptor, ionotropic, NMDA1 (zeta 1)
- Sequence Similarities
- Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR1/GRIN1 subfamily.
- Cellular Localization
- Cell membrane, Membrane, Postsynaptic cell membrane, Synapse
- Post Translation Modifications
- NMDA is probably regulated by C-terminal phosphorylation of an isoform of NR1 by PKC. Dephosphorylated on Ser-897 probably by protein phosphatase 2A (PPP2CB). Its phosphorylated state is influenced by the formation of the NMDAR-PPP2CB complex and the NMDAR channel activity (By similarity).
- Protein Refseq
- NP_001171127.1
- Function
- Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg2+.
Recommended Products
Isotype Control
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2039z | Mouse Anti-GRIN1 Recombinant Antibody (clone 37D5) | WB, ICC, IF, IHC | Mouse IgG1 |
| HPAB-0025-CN | Human Anti-GRIN1 Recombinant Antibody (HPAB-0025-CN) | ELISA, ICC, FC | Human IgG |
| HPAB-0026-CN | Human Anti-GRIN1 Recombinant Antibody (HPAB-0026-CN) | ELISA, ICC, FC | Human IgG |
| HPAB-0027-CN | Human Anti-GRIN1 Recombinant Antibody (HPAB-0027-CN) | ELISA, ICC, FC | Human IgG |
| VS3-FY616 | Recombinant Rabbit Anti-GRIN1 Antibody (clone R08-4B6) | WB | Rabbit IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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