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H3C1/H3C2

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Background

core component of the nucleosome. Nucleosomes wrap and compress DNA into chromatin, limiting DNA's accessibility to cellular machinery that requires DNA as a template. Thus, histones play central roles in transcriptional regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated by a complex set of histone post-translational modifications (also known as the histone code) and nucleosome remodeling. Miscellaneous This histone is present only in mammals and is enriched for acetylation of Lys-15 and dimethylation of Lys-10 (H3K9me2).
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