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HIF1A
Anti-HIF1A Recombinant Antibody Products
- Rabbit Anti-HIF1A Polyclonal Antibody (MRO-1928-CN) (MRO-1928-CN)
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- Species Reactivity: Human, Mouse
- Type: Rabbit IgG
- Application: WB, IF, FC
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- Rabbit Anti-HIF1A Polyclonal Antibody (MRO-1929-CN) (MRO-1929-CN)
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: IF, IHC, FC
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- Derivation: Mouse
- Species Reactivity: Human, Mouse, Rat
- Type: Mouse IgG1
- Application: WB, IP, ICC, IHC
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- Mouse Anti-HIF1A Recombinant Antibody (VS3-WK1354) (VS3-WK1354)
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- Derivation: Mouse
- Species Reactivity: Mouse
- Type: Mouse IgG
- Application: WB, IHC
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- Mouse Anti-HIF1A Monoclonal Antibody (VS7-0425-WR34) (VS7-0425-WR34)
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- Species Reactivity: Human, Mouse, Monkey
- Type: Mouse IgG
- Application: WB, IHC-P, IF, ICC, ELISA
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For Research Use Only. Not For Clinical Use.
This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2011]
Protein class
Cancer-related genes, Human disease related genes, Metabolic proteins, Plasma proteins, Transcription factors
Predicted location
Intracellular
Single cell type specificity
Low cell type specificity
Immune cell specificity
Immune cell enhanced (eosinophil)
Cell line specificity
Cell line enhanced (LHCN-M2)
Interaction
Interacts with the ARNT; forms a heterodimer that binds core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (PubMed:10944113, PubMed:20699359). Interacts with COPS5; the interaction increases the transcriptional activity of HIF1A through increased stability (By similarity). Interacts with EP300 (via TAZ-type 1 domains); the interaction is stimulated in response to hypoxia and inhibited by CITED2 (PubMed:8917528, PubMed:9887100, PubMed:12778114, PubMed:16543236, PubMed:16973622, PubMed:11959990). Interacts with CREBBP (via TAZ-type 1 domains) (PubMed:8917528, PubMed:11959977). Interacts with NCOA1, NCOA2, APEX1 and HSP90 (PubMed:10594042, PubMed:10202154). Interacts (hydroxylated within the ODD domain) with VHLL (via beta domain); the interaction, leads to polyubiquitination and subsequent HIF1A proteasomal degradation (PubMed:14757845). During hypoxia, sumoylated HIF1A also binds VHL; the interaction promotes the ubiquitination of HIF1A (PubMed:11006129, PubMed:10944113, PubMed:16862177, PubMed:12004076, PubMed:12050673). Interacts with SENP1; the interaction desumoylates HIF1A resulting in stabilization and activation of transcription (By similarity). Interacts (via the ODD domain) with NAA10; the interaction appears not to acetylate HIF1A nor have any affect on protein stability, during hypoxia (PubMed:12464182, PubMed:16288748). Interacts with RWDD3; the interaction enhances HIF1A sumoylation (PubMed:17956732, PubMed:23469069). Interacts with TSGA10 (By similarity). Interacts with HIF3A (By similarity). Interacts with RORA (via the DNA binding domain); the interaction enhances HIF1A transcription under hypoxia through increasing protein stability (PubMed:18658046). Interaction with PSMA7 inhibits the transactivation activity of HIF1A under both normoxic and hypoxia-mimicking conditions (PubMed:11389899). Interacts with USP20 (PubMed:15776016). Interacts with RACK1; promotes HIF1A ubiquitination and proteasome-mediated degradation (PubMed:17244529). Interacts (via N-terminus) with USP19 (PubMed:22128162). Interacts with SIRT2 (PubMed:24681946). Interacts (deacetylated form) with EGLN1 (PubMed:24681946). Interacts with CBFA2T3 (PubMed:25974097). Interacts with HSP90AA1 and HSP90AB1 (PubMed:26517842). Interacts with DCUN1D1; this interaction increases the interaction between VHL and DCUN1D1 (PubMed:23401859). Interacts with HIF1AN (PubMed:12446723).
Molecular function
Activator, DNA-binding
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