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IL17A
Engineered Antibody Products
Glyco-Engineering Antibody Products
Antibody Magnetic Beads
AbPlus
Recombinant Antibody Products
Functional Antibody Products
Formats
Research Area
Anti-IL17A Recombinant Antibody Products
- AbPlus™ Anti-IL17A Magnetic Beads (41809) (VS-0424-XY147)
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- Target: IL17A
- Target Species: Human
- Application: IP, Protein Purification
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For Research Use Only. Not For Clinical Use.
IL17A is a pro-inflammatory cytokine produced by Th17 cells, a subset of T-helper cells. It plays a key role in the immune system by promoting the recruitment of neutrophils and other immune cells to sites of infection and inflammation. IL17A is involved in autoimmune diseases such as rheumatoid arthritis, psoriasis, and inflammatory bowel disease (IBD). It activates a range of pro-inflammatory pathways that enhance immune cell responses. Overproduction of IL17A leads to chronic inflammation and tissue damage, contributing to the pathogenesis of these diseases.
Protein class
Cancer-related genes, FDA approved drug targets, Plasma proteins
Predicted location
Secreted
Single cell type specificity
Cell type enriched (T-cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Group enriched (Karpas-707, U-266/84)
Interaction
Homodimer (PubMed:19835883). Forms complexes with IL17RA and IL17RC receptors with 2:1 binding stoichiometry: two receptor chains for one interleukin molecule (PubMed:32187518). IL17A homodimer preferentially drives the formation of IL17RA-IL17RC heterodimeric receptor complex (PubMed:32187518). IL17A homodimer adopts an asymmetrical ternary structure with one IL17RA molecule, allowing for high affinity interactions of one IL17A monomer with one IL17RA molecule (via D1 and D2 domains), while disfavoring binding of a second IL17RA molecule on the other IL17A monomer (PubMed:23695682). Heterodimer with IL17F (PubMed:17355969). IL17A-IL17F forms complexes with IL17RA-IL17RC, but with lower affinity when compared to IL17A homodimer (PubMed:32187518). IL17RA and IL17RC chains cannot distinguish between IL17A and IL17F molecules, potentially enabling the formation of topologically distinct complexes (PubMed:17355969, PubMed:28827714).
Molecular function
Cytokine
More Types Infomation
Related Diseases
Inflammatory Bowel Diseases