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For Research Use Only. Not For Clinical Use.
Candidate cardiovascular disease genes, Enzymes, Plasma proteins
Intracellular, Membrane, Secreted (different isoforms)
Cell type enriched (granulocytes)
Group enriched (basophil, eosinophil)
Group enriched (HHSteC, HMC-1, HUVEC TERT2)
Interacts with MYD88, IRAK1, IRAK4, and TRAF6. Bound to its ligand IL-33, interacts with IL1RAP to form the minimal interleukin-33 signaling complex with a 1:1:1 stoichiometry. Interacts with KIT (bound to KITLG/SCF). A mast cell-specific KITLG/SCF-induced interleukin-33 signaling complex contains IL1RL1, IL1RAP, KIT and MYD88. Interacts with TMED1 (PubMed:23319592).
Hydrolase, Receptor