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IRAK4
Anti-IRAK4 Recombinant Antibody Products
- Anti-Human IRAK4 Recombinant Antibody (TAB-451CL)
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- Species Reactivity: Human
- Type: Antibody
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- Mouse Anti-IRAK4 Recombinant Antibody; scFv Fragment (TAB-0587CL-S(P)) (TAB-0587CL-S(P))
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA
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- Mouse Anti-IRAK4 Recombinant Antibody; Fab Fragment (TAB-0587CL-F(E)) (TAB-0587CL-F(E))
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA
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- Mouse Anti-NHP IRAK4 Recombinant Antibody (clone 2H9) (VS-1024-XY284)
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- Species Reactivity: Human, Mouse, Non-human primate
- Type: Mouse IgG1
- Application: WB, IHC, FC, ELISA
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For Research Use Only. Not For Clinical Use.
This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene.
Protein class
Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets
Predicted location
Intracellular
Single cell type specificity
Low cell type specificity
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (U-937)
Interaction
Associates with MYD88 and IRAK2 to form a ternary complex called the Myddosome (PubMed:16951688, PubMed:24316379). Once phosphorylated, IRAK4 dissociates from the receptor complex and then associates with the TNF receptor-associated factor 6 (TRAF6), IRAK1, and PELI1; this intermediate complex is required for subsequent NF-kappa-B activation (PubMed:11960013, PubMed:12496252, PubMed:16951688). Direct binding of SMAD6 to PELI1 prevents complex formation and hence negatively regulates IL1R-TLR signaling and eventually NF-kappa-B-mediated gene expression (PubMed:16951688). Interacts with IL1RL1 (PubMed:16286016). Interacts (when phosphorylated) with IRAK1 (PubMed:33238146). May interact (when phosphorylated) with IRAK3 (PubMed:33238146).
Molecular function
Kinase, Serine/threonine-protein kinase, Transferase
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Related Signaling Pathways
TLR Signaling Pathway
Related Diseases
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