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LEF1

Anti-LEF1 Recombinant Antibody Products

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For Research Use Only. Not For Clinical Use.


Lymphoid enhancer-binding factor-1 (LEF1) is a 48-kD nuclear protein that is expressed in pre-B and T cells. It binds to a functionally important site in the T-cell receptor-alpha (TCRA) enhancer and confers maximal enhancer activity.
Protein class

Cancer-related genes, Plasma proteins, Transcription factors

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Microglial cells, T-cells, Melanocytes)

Immune cell specificity

Immune cell enhanced (naive CD4 T-cell)

Cell line specificity

Group enriched (JURKAT, MOLT-4, REH)

Interaction

Binds the armadillo repeat of CTNNB1 and forms a stable complex. Interacts with EP300, TLE1 and PIASG (By similarity). Binds ALYREF/THOC4, MDFI and MDFIC. Interacts with NLK.

Molecular function

Activator, DNA-binding

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