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PRKCQ
Anti-PRKCQ Recombinant Antibody Products
- Rabbit Anti-PRKCQ Recombinant Antibody (VS13-YC941) (VS13-YC941)
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: IHC-P
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For Research Use Only. Not For Clinical Use.
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipid-dependent protein kinase. This kinase is important for T-cell activation. It is required for the activation of the transcription factors NF-kappaB and AP-1, and may link the T cell receptor (TCR) signaling complex to the activation of the transcription factors.
Protein class
Cancer-related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Oligodendrocytes, NK-cells, T-cells, Oligodendrocyte precursor cells, Astrocytes, dendritic cells)
Immune cell specificity
Group enriched (T-reg, memory CD8 T-cell, memory CD4 T-cell, gdT-cell, naive CD4 T-cell, MAIT T-cell, naive CD8 T-cell, NK-cell)
Cell line specificity
Cell line enhanced (HEL, JURKAT, MOLT-4)
Interaction
Part of a lipid raft complex composed at least of BCL10, CARD11, MALT1 and IKBKB (PubMed:16356855). Interacts with GLRX3 (via N-terminus) (PubMed:10636891). Interacts with ECT2 (PubMed:15254234). Interacts with CCDC88A/GIV; the interaction leads to phosphorylation of CCDC88A and inhibition of its guanine nucleotide exchange factor activity (PubMed:23509302). Interacts with PRKCH upstream open reading frame 2; the interaction leads to inhibition of kinase activity (PubMed:34593629).
Molecular function
Kinase, Serine/threonine-protein kinase, Transferase
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