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PTN
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- Mouse Anti-PTN Recombinant Antibody (clone 39C3) (MOB-2000z)
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: WB, FC, IF, IHC, IP
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- Human Anti-PTN Antibody, mRNA (TAB-721CL-mRNA)
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- Species Reactivity: Human
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- Recombinant Rabbit Anti-PTN Antibody (clone R01-2J3) (VS3-FY1223)
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- Species Reactivity: Human, Rat
- Type: Rabbit IgG
- Application: WB, IP
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- Anti-Human PTN Recombinant Antibody (4B2) (TAB-290CT)
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- Derivation: Mouse hybridoma cell lines
- Species Reactivity: Human
- Application: WB, ELISA, IHC, Neut
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- Anti-Human PTN Recombinant Antibody (3-4A) (TAB-291CT)
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- Derivation: Mouse hybridoma cell lines
- Species Reactivity: Human
- Application: WB, ELISA, IHC, Neut
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- Anti-Human PTN Recombinant Antibody scFv Fragment (4B2) (TAB-290CT-S(P))
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- Derivation: Mouse hybridoma cell lines
- Species Reactivity: Human
- Application: WB, ELISA, IHC, Neut
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- Anti-Human PTN Recombinant Antibody scFv Fragment (3-4A) (TAB-291CT-S(P))
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- Derivation: Mouse hybridoma cell lines
- Species Reactivity: Human
- Application: WB, ELISA, IHC, Neut
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- Anti-Human PTN Recombinant Antibody Fab Fragment (4B2) (TAB-290CT-F(E))
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- Derivation: Mouse hybridoma cell lines
- Species Reactivity: Human
- Application: WB, ELISA, IHC, Neut
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- Anti-Human PTN Recombinant Antibody Fab Fragment (3-4A) (TAB-291CT-F(E))
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- Derivation: Mouse hybridoma cell lines
- Species Reactivity: Human
- Application: WB, ELISA, IHC, Neut
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- Anti-Human PTN Recombinant Antibody (3B10) (TAB-0333CL)
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- Application: IHC, IF, Block, ELISA
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- Anti-Human PTN Recombinant Antibody scFv Fragment (3B10) (TAB-0333CL-S(P))
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- Application: FuncS, Inhib
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- Anti-Human PTN Recombinant Antibody Fab Fragment (3B10) (TAB-0333CL-F(E))
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- Application: FuncS, Inhib
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- Anti-Mouse PTN Immunohistochemistry Kit (VS-0525-XY5855)
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- Species Reactivity: Human, Mouse
- Target: PTN
- Application: IHC
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: WB, IP
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- Anti-PTN Immunohistochemistry Kit (VS-0525-XY5853)
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- Species Reactivity: Human
- Target: PTN
- Application: IHC
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- Anti-Rat PTN Immunohistochemistry Kit (VS-0525-XY5854)
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- Species Reactivity: Human, Rat, Chicken
- Target: PTN
- Application: IHC
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For Research Use Only. Not For Clinical Use.
The protein encoded by this gene is a secreted heparin-binding growth factor. The protein has significant roles in cell growth and survival, cell migration, angiogenesis and tumorigenesis.
Protein class
Cancer-related genes
Predicted location
Secreted
Single cell type specificity
Cell type enhanced (Endometrial stromal cells, Muller glia cells, Horizontal cells, Squamous epithelial cells, Extravillous trophoblasts, Oligodendrocyte precursor cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enriched (AF22)
Interaction
Interacts with ALK and NEK6 (PubMed:11278720, 20873783). Interacts with PTPRZ1 (via chondroitin sulfate groups); promotes formation of homooligomers; oligomerization impairs tyrosine phosphatase activity (PubMed:16814777) (Probable). Forms a complex with PTPRZ1 and CTNNB1; this complex inactivates PTPRZ1 protein tyrosine phosphatase activity through PTN interaction and stimulates tyrosine phosphorylation of CTNNB1 (PubMed:10706604). Interacts with ITGB3 AND ITGA5 (PubMed:19141530). Forms a complex with PTPRZ1 and integrin alpha-V/beta-3 (ITGAV:ITGB3) that stimulates endothelial cell migration through ITGB3 'Tyr-773' phosphorylation (PubMed:19141530). Interacts with SDC3 (via heparan sulfate chains); this interaction mediates the neurite outgrowth-promoting signal from PTN to the cytoskeleton of growing neurites; this interaction mediates osteoblast recruitment. Interacts with GPC2 (via heparan sulfate); this interaction promotes neurite outgrowth through binding of PTN with chondroitin sulfate of proteoglycans, thereby releasing PTPRS of chondroitin sulfate proteoglycans (CSPGs) and leading to binding with heparan sulfate of GPC2 (By similarity).
Molecular function
Growth factor, Heparin-binding, Mitogen
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