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TCIRG1
Loading...Anti-TCIRG1 Products
- Anti-Human TCIRG1 Recombinant Antibody (TAB-594CL)
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- Derivation: Chimeric (human/mouse)
- Species Reactivity: Human
- Type: Antibody
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- Human Anti-TCIRG1 Antibody, mRNA (TAB-594CL-mRNA)
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- Species Reactivity: Human
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- Human Anti-TCIRG1 Recombinant Antibody (clone Metiliximab) (HPAB-0340-WJ)
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized IgG1, κ
- Application: ELISA
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- Human Anti-TCIRG1 Recombinant Antibody (clone Neliximab) (HPAB-0341-WJ)
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized IgG1, κ
- Application: ELISA
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- Recombinant Anti-Human TCIRG1 Antibody Fab Fragment (MOB-3563z-F(E))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Fab
- Application: IF, Neut, FuncS
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- Recombinant Anti-Human TCIRG1 Antibody scFv Fragment (MOB-3563z-S(P))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: scFv
- Application: IP, IF, Biosensors, FuncS
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- Human Anti-TCIRG1 Recombinant Antibody (clone Metiliximab); scFv Fragment (HPAB-0340-WJ-S(P))
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized scFv
- Application: ELISA
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- Human Anti-TCIRG1 Recombinant Antibody (clone Neliximab); scFv Fragment (HPAB-0341-WJ-S(P))
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized scFv
- Application: ELISA
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- Human Anti-TCIRG1 Recombinant Antibody (clone Metiliximab); Fab Fragment (HPAB-0340-WJ-F(E))
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized Fab
- Application: ELISA
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- Human Anti-TCIRG1 Recombinant Antibody (clone Neliximab); Fab Fragment (HPAB-0341-WJ-F(E))
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized Fab
- Application: ELISA
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- Species Reactivity: Human
- Target: TCIRG1
- Host Animal: Human
- Application: ELISA, FC, Cell-uptake
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- Anti-TCIRG1 Immunohistochemistry Kit (VS-0525-XY7142)
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- Species Reactivity: Human
- Target: TCIRG1
- Application: IHC
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For Research Use Only. Not For Clinical Use.
Background
This gene encodes a subunit of a large protein complex known as a vacuolar H+-ATPase (V-ATPase). The protein complex acts as a pump to move protons across the membrane. This movement of protons helps regulate the pH of cells and their surrounding environment. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis. V-ATPase is comprised of a cytosolic V1 domain and a transmembrane V0 domain. Alternative splicing results in multiple transcript variants. Mutations in this gene are associated with infantile malignant osteopetrosis. [provided by RefSeq, May 2017]
Protein class
Disease related genes, Human disease related genes, Metabolic proteins
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (Gastric mucus-secreting cells, Macrophages, Kupffer cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (HMC-1, RPMI-8226)
Interaction
V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex (By similarity). The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H (By similarity). The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits ATP6AP1/Ac45 and ATP6AP2/PRR (By similarity).
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