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TFPI
Anti-TFPI Recombinant Antibody Products
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For Research Use Only. Not For Clinical Use.
This gene encodes a Kunitz-type serine protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. The product of this gene inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop. Inhibition of the encoded protein restores hemostasis in animal models of hemophilia. This gene encodes multiple protein isoforms that differ in their inhibitory activity, specificity and cellular localization. [provided by RefSeq, Jul 2016]
Protein class
Candidate cardiovascular disease genes, FDA approved drug targets, Plasma proteins
Predicted location
Secreted
Single cell type specificity
Cell type enhanced (Extravillous trophoblasts, Syncytiotrophoblasts, Hepatic stellate cells)
Immune cell specificity
Group enriched (basophil, plasmacytoid DC, neutrophil)
Cell line specificity
Cell line enhanced (HHSteC, HUVEC TERT2, LHCN-M2, TIME)
Molecular function
Protease inhibitor, Serine protease inhibitor
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