Anti-CD22 (clone 10F4v3)-MCC-DM1 ADC
CAT#: ADC-194LZY
This ADC product is composed of an anti-CD22 antibody (clone 10F4v3 ) conjugated via MCC linker to DM1 (10F4v3-MCC-DM1). It has demonstrated a response in non-Hodgkin's lymphoma treatment by a MOA (Mechanism of Action) of microtubules depolymerizing.
Gene Expression
Normal Tissue
Figure 1 Lymph node
Germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2418/6101_A_7_8.jpg
Normal Tissue
Figure 2 Spleen
Cells in red pulp
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Cells in white pulp
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2418/6101_B_7_4.jpg
RNA Expression
Figure 3 RNA cell line category: Cell line enhanced (Daudi, REH, U-698, WM-115)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000012124-CD22
❮
❯
Specifications
- Antibody Overview
- Humanized Anti-CD22 IgG1,10F4v3
- Clone
- 10F4v3
- Antibody Isotype
- IgG1
- Linker
- MCC(Maleimidomethyl cyclohexane-1-carboxylate)
- Linker Class/Description
- Class: Noncleavable linker
Description: Noncleavable linker is considered noncleavable-meaning linker cleavage, and payload release does not depend on the differential properties between the plasma and some cytoplasmic compartments. Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation
- Drug
- DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
- Drug Class/Description
- Class: Maytansinoid
Description: Maytansinoids are a group of cytotoxins structurally similar to rifamycin, geldanamycin, and ansatrienin. The eponymous natural cytotoxic agent maytansine is a 19-member lactam (ansa
macrolide) structure originally isolated from the Ethiopian shrub Maytenus ovatus. Maytansinoids can bind to tubulin at or near the vinblastine-binding site, which interfere the formation of microtubules and depolymerize already formed microtubules, inducing mitotic arrest in the intoxicated cells
Target
- Introduction
- CD22, or cluster of differentiation-22, is a molecule belonging to the SIGLEC family of lectins. It is found on the surface of mature B cells and to a lesser extent on some immature B cells. Generally speaking, CD22 is a regulatory molecule that prevents the overactivation of the immune system and the development of autoimmune diseases.
CD22 is a sugar binding transmembrane protein, which specifically binds sialic acid with an immunoglobulin (Ig) domain located at its N-terminus. The presence of Ig domains makes CD22 a member of the immunoglobulin superfamily. CD22 functions as an inhibitory receptor for B cell receptor (BCR) signaling. It is also involved in the B cell trafficking to Peyer's patches in mice.
- Alternative Names
- CD22; CD22 molecule; SIGLEC2; SIGLEC-2; B-cell receptor CD22; BL-CAM; CD22 antigen; T-cell surface antigen Leu-14; B-lymphocyte cell adhesion molecule; sialic acid binding Ig-like lectin 2; sialic acid-binding Ig-like lectin 2;
- Gene ID
- 933
- UniProt ID
- P20273
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for ADC-194LZY. Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "Clone 10F4v3"
- CAT
- Product Name
See other products for "CD22"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-198 | Humanized Anti-CD22 Recombinant Antibody (clone Inotuzumab) | ELISA, FC, IP, FuncS, IF, Neut, ICC | Humanized (from mouse) IgG4, κ |
| TAB-1725CL-S(P) | Human Anti-CD22 Recombinant Antibody; scFv Fragment (TAB-1725CL-S(P)) | Block, Cyt, ELISA, FuncS | Humanized scFv |
| TAB-1729CL-S(P) | Human Anti-CD22 Recombinant Antibody; scFv Fragment (TAB-1729CL-S(P)) | IF, FC | Humanized scFv |
| TAB-1725CL-F(E) | Human Anti-CD22 Recombinant Antibody; Fab Fragment (TAB-1725CL-F(E)) | Block, Cyt, ELISA, FuncS | Humanized Fab |
| TAB-1729CL-F(E) | Human Anti-CD22 Recombinant Antibody; Fab Fragment (TAB-1729CL-F(E)) | IF, FC | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-L048E | anti-CD22 immunotoxin RFB4 (scFv)-PE | Cytotoxicity assay, Functional assay | |
| AGTO-L048D | anti-CD22 immunotoxin RFB4 (scFv)-DT | Cytotoxicity assay, Functional assay | |
| AGTO-L048G | anti-CD22 immunotoxin RFB4 (scFv)-Gel | Cytotoxicity assay, Functional assay | |
| AGTO-L048R | anti-CD22 immunotoxin RFB4 (scFv)-RTA | Cytotoxicity assay, Functional assay | |
| AGTO-L048S | anti-CD22 immunotoxin RFB4 (scFv)-Sap | Cytotoxicity assay, Functional assay |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0196CL | Anti-Human CD22 Recombinant Antibody (hLL2) | Inhib, Cyt, FC, WB | |
| TAB-0197CL | Anti-Human CD22 Recombinant Antibody (hLL2-Cys) | ELISA, In vivo | |
| TAB-1722CL | Human Anti-CD22 Recombinant Antibody (TAB-1722CL) | ELISA, FC, FuncS | Human antibody |
| TAB-0196CL-S(P) | Anti-Human CD22 Recombinant Antibody scFv Fragment (hLL2) | ELISA, In vivo | |
| TAB-0197CL-S(P) | Anti-Human CD22 Recombinant Antibody scFv Fragment (hLL2-Cys) | ELISA, In vivo |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1724CL | Human Anti-CD22 Recombinant Antibody (TAB-1724CL) | Inhib | Chimeric (mouse/human) IgG1, κ |
| TAB-1724CL-S(P) | Mouse Anti-CD22 Recombinant Antibody; scFv Fragment (TAB-1724CL-S(P)) | Inhib | Mouse scFv |
| TAB-1724CL-F(E) | Human Anti-CD22 Recombinant Antibody; Fab Fragment (TAB-1724CL-F(E)) | Inhib | Chimeric (mouse/human) Fab |
| TAB-001LC | Human Anti-CD22 Recombinant Antibody (TAB-001LC) | ELISA | Chimeric antibody (mouse/human) |
| TAB-001LC-S(P) | Mouse Anti-CD22 Recombinant Antibody; scFv Fragment (TAB-001LC-S(P)) | ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-001LC | Recombinant Anti-Human CD22 Antibody (Fab glycosylation) | ELISA, FC | Mouse antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-111LC | Recombinant Anti-Human CD22 Antibody (Fc glycosylation) | ELISA | Chimeric antibody (mouse/human) |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-315CQ | Rat Anti-CD22 Recombinant Antibody (clone 2D6) | Block | Rat IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0545 | Hi-Affi™ Rabbit Anti-CD22 Recombinant Antibody (clone DS545AB) | IP, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0195-LSX | Human Anti-CD22 Recombinant Antibody (HPAB-0195-LSX) | Apop, Cyt, FC, WB, Inhib, FuncS, IF, ELISA | Human IgG |
| HPAB-0196-LSX | Mouse Anti-CD22 Recombinant Antibody (HPAB-0196-LSX) | ELISA, FC, IP, RIA | Mouse IgG |
| HPAB-0197-LSX | Human Anti-CD22 Recombinant Antibody (HPAB-0197-LSX) | ELISA, FC, FuncS | Human IgG |
| HPAB-0198-LSX | Mouse Anti-CD22 Recombinant Antibody (HPAB-0198-LSX) | ELISA, WB, IF, FC, SPR | Mouse IgG |
| HPAB-0199-LSX | Human Anti-CD22 Recombinant Antibody (HPAB-0199-LSX) | ELISA, FC | Human IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0194-LSX-S(P) | Mouse Anti-CD22 Recombinant Antibody; scFv Fragment (HPAB-0194-LSX-S(P)) | ELISA | Mouse scFv |
| HPAB-0195-LSX-S(P) | Human Anti-CD22 Recombinant Antibody; scFv Fragment (HPAB-0195-LSX-S(P)) | ELISA | Human scFv |
| HPAB-0196-LSX-S(P) | Mouse Anti-CD22 Recombinant Antibody; scFv Fragment (HPAB-0196-LSX-S(P)) | ELISA | Mouse scFv |
| HPAB-0197-LSX-S(P) | Human Anti-CD22 Recombinant Antibody; scFv Fragment (HPAB-0197-LSX-S(P)) | ELISA | Human scFv |
| HPAB-0198-LSX-S(P) | Mouse Anti-CD22 Recombinant Antibody; scFv Fragment (HPAB-0198-LSX-S(P)) | ELISA, FC | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0194-LSX-F(E) | Mouse Anti-CD22 Recombinant Antibody; Fab Fragment (HPAB-0194-LSX-F(E)) | ELISA | Mouse Fab |
| HPAB-N0324-YC-F(E) | Mouse Anti-CD22 Recombinant Antibody; Fab Fragment (HPAB-N0324-YC-F(E)) | FuncS | Mouse Fab |
| HPAB-N0325-YC-F(E) | Mouse Anti-CD22 Recombinant Antibody; Fab Fragment (HPAB-N0325-YC-F(E)) | FuncS | Mouse Fab |
| HPAB-0370-FY-F(E) | Human Anti-CD22 Recombinant Antibody; Fab Fragment (HPAB-0370-FY-F(E)) | ELISA | Humanized Fab |
| HPAB-0371-FY-F(E) | Human Anti-CD22 Recombinant Antibody; Fab Fragment (HPAB-0371-FY-F(E)) | Inhib | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-176 | Afuco™ Anti-CD22 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-176) | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
| AFC-TAB-198 | Afuco™ Anti-CD22 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-198) | ELISA, FC, IP, FuncS, IF, Neut | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY50 | AbPlus™ Anti-CD22 Magnetic Beads (DM13) | IP, Protein Purification | |
| VS-0724-YC918 | AbPlus™ Anti-Cd22 Magnetic Beads (VS-0724-YC918) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY24 | CytoStream™ Mouse Anti-CD22 Recombinant Antibody (VS-0225-XY24) | FC | Mouse IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY357 | Anti-CD22 Immunohistochemistry Kit | IHC | |
| VS-0525-XY1143 | Anti-Human CD22 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY82 | Human Anti-CD22 (clone Inotuzumab) scFv-Fc Chimera | ELISA | Human IgG4, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC225 | Recombinant Anti-CD22 Vesicular Antibody, EV Displayed (VS-0425-YC225) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC201 | Recombinant Anti-CD22 (Epitope A x Epitope B) Biparatopic Antibody, Tandem scFv | ELISA, FC, ICC, IF, IP, Neut | Tandem scFv |
Specific Inquiry
Add to compare
See Our Custom Production in Action
Popular Products
Application: IF, IP, Neut, FuncS, ELISA, FC, ICC
Application: Neut, ELISA, IF, IP, FuncS, FC, ICC
Application: WB, FuncS, IF, Neut, ELISA, FC, IP
Application: Neut, ELISA, IF, IP, FuncS, FC, ICC
Application: ELISA
Application: ELISA, SPR, Inhib, FuncS
Application: Neut, Inhib, FC, ELISA
-3.jpg)
Application: ELISA, IHC, FC, IP, IF, Inhib
Application: ELISA, WB
Application: ELISA, FC, FuncS
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
