Anti-CD22 (clone 10F4v3)-SPP-DM1 ADC (CAT#: ADC-221CL)

• Antibody Overview
• Anti-CD22 Antibody Humanized 10F4v3

• Clone
• 10F4v3

• Linker
• SPP (N-succinimidyl-4-(2-pyridyldithio)pentanoate)

• Linker Class/Description
• Class: Chemically cleavable linkers-Disulfide Linkers
  Description: Disulfide Linkers are extensively exploited as a chemically labile linkage. Since the release of disulfide-linked drugs requires a cytoplasmic thiol cofactor, such as glutathione (GSH). Disulfides maintain stable at physiological pH and only when ADCs are internalized inside cells, the cytosol provides reducing environment including intracellular enzyme protein disulfide isomerase, or similar enzymes, drugs can be released.

• Drug
• DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)

• Drug Class/Description
• Class: Maytansinoid
  Description: Maytansinoids are a group of cytotoxins structurally similar to rifamycin, geldanamycin, and ansatrienin. The eponymous natural cytotoxic agent maytansine is a 19-member lactam (ansa
  macrolide) structure originally isolated from the Ethiopian shrub Maytenus ovatus. Maytansinoids can bind to tubulin at or near the vinblastine-binding site, which interfere the formation of microtubules and depolymerize already formed microtubules, inducing mitotic arrest in the intoxicated cells.

• Introduction
• CD22, or cluster of differentiation-22, is a molecule belonging to the SIGLEC family of lectins. It is found on the surface of mature B cells and to a lesser extent on some immature B cells. Generally speaking, CD22 is a regulatory molecule that prevents the overactivation of the immune system and the development of autoimmune diseases.
  CD22 is a sugar binding transmembrane protein, which specifically binds sialic acid with an immunoglobulin (Ig) domain located at its N-terminus. The presence of Ig domains makes CD22 a member of the immunoglobulin superfamily. CD22 functions as an inhibitory receptor for B cell receptor (BCR) signaling. It is also involved in the B cell trafficking to Peyer's patches in mice.

• Alternative Names
• CD22; CD22 molecule; SIGLEC2; SIGLEC-2; B-cell receptor CD22; BL-CAM; CD22 antigen; T-cell surface antigen Leu-14; B-lymphocyte cell adhesion molecule; sialic acid binding Ig-like lectin 2; sialic acid-binding Ig-like lectin 2;

• Gene ID
• 933

• UniProt ID
• P20273

• ADC-211CL
• Anti-CD22 (clone 10F4v3)-BMPEO-DM1 ADC

• ADC-212CL
• Anti-CD22 (clone 10F4v3)-MC-MMAF ADC

• ADC-213CL
• Anti-CD22 (clone 10F4v3)-MC-vc-PAB-MMAE ADC

• ADC-194LZY
• Anti-CD22 (clone 10F4v3)-MCC-DM1 ADC

• ADC-219CL
• Anti-CD22 (clone 10F4v3)-SMCC-DM1 ADC

• ADC-195LZY
• Anti-CD22 (clone 10F4v3)-mc-vc-PABC-MMAE ADC

• ADC-220CL
• Anti-CD22 (clone 10F4v3)-MC-MMAF ADC

• ADC-222CL
• Anti-CD22 (clone 10F4v3)-MC-vc-PAB-MMAE ADC

• ADC-228CL
• Anti-CD22 (clone 10F4v3)-MC-vc-PAB-MMAE ADC

• ADC-230CL
• Anti-CD22 (clone 10F4v3)-MC-vc-PAB-MMAE ADC

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