Afuco™ Anti-Human DDR1 ADCC Recombinant Antibody, ADCC Enhanced
CAT#: AFC-199CL
Anti-DDR1 ADCC Enhanced Antibody is an ADCC enhanced antibody produced by our Afuco™ platform. This is an antibody that specifically binds to the extracellular domain of human discoidin domain receptor 1 (DDR1) outside the discoidin domain, and which reduces or blocks collagen- induced autophosphorylation of DDR1 without preventing collagen binding to DDR1. Discoidin domain receptor 1 (DDR1) is a receptor tyrosine kinase that is a promising therapeutic target for a number of aggressive cancers.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line MCF7
Immunofluorescent staining of human cell line MCF7 shows localization to nucleoplasm & cell junctions.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/57194/if_selected.jpg
Normal Tissue
Figure 2 Lymph node
Germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/25656/57796_A_9_8.jpg
Normal Tissue
Figure 3 Cerebral cortex
Endothelial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Glial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuronal cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/25656/57796_B_7_5.jpg
Normal Tissue
Figure 4 Kidney
Cells in tubules Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/25656/57796_A_8_5.jpg
Normal Tissue
Figure 5 Testis
Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/25656/57796_A_5_6.jpg
Normal Tissue
Figure 6 Skin
Melanocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/25656/57796_B_7_1.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enhanced (HaCaT, HBEC3-KT, RT4, T-47d)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000204580-DDR1
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Specifications
- Host Species
- Human
- Type
- ADCC enhanced antibody
- Species Reactivity
- Human
- Related Disease
- Cancer
Product Property
- Purity
- >95%, by SDS-PAGE with Coomassie Brilliant Blue staining
- Storage
- Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C.
Target
- Alternative Names
- DDR1; discoidin domain receptor tyrosine kinase 1; CAK; DDR; NEP; HGK2; PTK3; RTK6; TRKE; CD167; EDDR1; MCK10; NTRK4; PTK3A; epithelial discoidin domain-containing receptor 1; tyrosine kinase DDR; cell adhesion kinase; mammary carcinoma kinase 10; tyrosine-protein kinase CAK; protein-tyrosine kinase RTK-6; neuroepithelial tyrosine kinase; PTK3A protein tyrosine kinase 3A; CD167 antigen-like family member A; neurotrophic tyrosine kinase, receptor, type 4
- Gene ID
- 780
- UniProt ID
- Q08345
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "DDR1"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-176MZ-S(P) | Anti-Human DDR1 Recombinant Antibody scFv Fragment (DDR1-ab1) | IF | Human antibody |
| TAB-177MZ-S(P) | Anti-Human DDR1 Recombinant Antibody scFv Fragment (DDR1-ab2) | IF | Human antibody |
| TAB-178MZ-S(P) | Anti-Human DDR1 Recombinant Antibody scFv Fragment (DDR1-ab3) | IF | Human antibody |
| TAB-176MZ-F(E) | Anti-Human DDR1 Recombinant Antibody Fab Fragment (DDR1-ab1) | IF | Human antibody |
| PABX-043-S (P) | Recombinant Mouse Anti-DDR1 Antibody scFv Fragment (3E3) | WB, Neut, FuncS | scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0953 | Hi-Affi™ Rabbit Anti-DDR1 Recombinant Antibody (clone DS953AB) | ELISA, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0061-LSX | Mouse Anti-DDR1 Recombinant Antibody (clone AB2026) | ELISA | Mouse IgG |
| HPAB-0062-LSX | Mouse Anti-DDR1 Recombinant Antibody (clone AB2039) | ELISA | Mouse IgG |
| HPAB-0063-LSX | Mouse Anti-DDR1 Recombinant Antibody (clone AB2031) | ELISA | Mouse IgG |
| HPAB-0064-LSX | Mouse Anti-DDR1 Recombinant Antibody (clone AB2074) | ELISA | Mouse IgG |
| HPAB-0065-LSX | Mouse Anti-DDR1 Recombinant Antibody (clone AB2078) | ELISA | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0061-LSX-S(P) | Mouse Anti-DDR1 Recombinant Antibody (clone AB2026); scFv Fragment | ELISA | Mouse scFv |
| HPAB-0062-LSX-S(P) | Mouse Anti-DDR1 Recombinant Antibody (clone AB2039); scFv Fragment | ELISA | Mouse scFv |
| HPAB-0063-LSX-S(P) | Mouse Anti-DDR1 Recombinant Antibody (clone AB2031); scFv Fragment | ELISA | Mouse scFv |
| HPAB-0064-LSX-S(P) | Mouse Anti-DDR1 Recombinant Antibody (clone AB2074); scFv Fragment | ELISA | Mouse scFv |
| HPAB-0125-YJ-S(P) | Human Anti-DDR1 Recombinant Antibody (clone CBD02YJ); scFv Fragment | FC, ELISA, Inhib | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0061-LSX-F(E) | Mouse Anti-DDR1 Recombinant Antibody (clone AB2026); Fab Fragment | ELISA | Mouse Fab |
| HPAB-0062-LSX-F(E) | Mouse Anti-DDR1 Recombinant Antibody (clone AB2039); Fab Fragment | ELISA | Mouse Fab |
| HPAB-0063-LSX-F(E) | Mouse Anti-DDR1 Recombinant Antibody (clone AB2031); Fab Fragment | ELISA | Mouse Fab |
| HPAB-0064-LSX-F(E) | Mouse Anti-DDR1 Recombinant Antibody (clone AB2074); Fab Fragment | ELISA | Mouse Fab |
| HPAB-0065-LSX-F(E) | Mouse Anti-DDR1 Recombinant Antibody (clone AB2078); Fab Fragment | ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC1235 | AbPlus™ Anti-DDR1 Magnetic Beads (VS-0724-YC1235) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY638 | Anti-DDR1 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC431 | Recombinant Anti-DDR1 Vesicular Antibody, EV Displayed (VS-0425-YC431) | ELISA, FC, Neut, Cell-uptake |
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