Anti-Human CD3 epsilon Recombinant Antibody (Foralumab) (CAT#: TAB-245)
Recombinant monoclonal antibody to CD3 epsilon. Foralumab is an immunomodulator. It binds to CD3 epsilon.
Specific Inquiry
FC
Figure 1 Systemic absorption of foralumab: Serum and splenocytes were isolated from humanized mice 7 days after the 7th dose of foralumab or control hIg.
A: Cell surface bound human immunoglobulin was detected with an anti-human IgG Fc antibody by FACS and costaining with CD2+CD4+, CD2+CD8+, and CD2? cells. B: Serum was obtained from mice having received 1, 5, or 15 ?g of foralumab and used to stain human PBMCs. The histograms show indirect staining of the human IgG on CD2+CD4+ and CD2+CD8+ lymphocytes with serum from mice treated with 5 ?g (gray histogram) or 15 ?g (black histogram). C: The relationship between oral dose of foralumab and serum concentration is shown. The dots represent median concentrations (n = 3-4).
Ogura, M., Deng, S., Preston-Hurlburt, P., Ogura, H., Shailubhai, K., Kuhn, C.,... & Herold, K. C. (2017). Oral treatment with foralumab, a fully human anti-CD3 monoclonal antibody, prevents skin xenograft rejection in humanized mice. Clinical Immunology, 183, 240-246.
Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Human
- Derivation
- Human
- Type
- IgG1 - kappa
- Specificity
- Tested positive against native human antigen.
- Species Reactivity
- Human
- Applications
- WB, ELISA, FC, IP, FuncS, IF, Neut
- CAS
- 946415-64-1
- Generic Name
- Foralumab
- UNII
- J43DL56H6M
- Related Disease
- Atherosclerosis
Product Property
- Purity
- >95.0% as determined by analysis by SDS-PAGE.
- Storage
- Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C.
Applications
- Application Notes
- The CD3E antibody has been reported in applications of WB, ELISA, FC, IP, FuncS, IF, Neut.
Target
- Alternative Names
- Foralumab;946415-64-1;CD3E;CD3e molecule, epsilon (CD3-TCR complex);CD3e antigen, epsilon polypeptide (TiT3 complex);T-cell surface glycoprotein CD3 epsilon chain;CD3-epsilon;T-cell surface antigen T3/Leu-4 epsilon chain;T-cell antigen receptor complex, e
- Gene ID
- 916
- UniProt ID
- P07766
Related Resources
Please refer to Foralumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Foralumab.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Foralumab"
Afuco™ Anti-CD3E ADCC Recombinant Antibody (Foralumab), ADCC EnhancedThis product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to CD3 epsilon. Foralumab is an immunomodulator. It binds to CD3 epsilon.
See other products for "CD3E"
Rat Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-H28 | Anti-Human CD3E Recombinant Antibody (Ertumaxomab) | ELISA, FC, IP, FuncS, IF, Neut, ICC | IgG2a / G2b |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| DrMAB-988 | Mouse Anti-CD3E Recombinant Antibody (clone UCHT1) | FC, IHC, WB, FuncS, IF | Mouse IgG1 F(ab')2 |
| DrMAB-989 | Mouse Anti-CD3E Recombinant Antibody (clone UCHT1); Fab Fragment | FC, Cyt, Stim, PP, Agonist | Mouse Fab |
| FAMAB-0047CQ-F(E) | Mouse Anti-CD3E Recombinant Antibody (clone CLB-T3/4.1); Fab Fragment | ELISA, IF, IP | Mouse Fab |
| HPAB-0263-YJ-F(E) | Rabbit Anti-CD3E Recombinant Antibody (clone 645); Fab Fragment | ELISA, FC, FuncS | Rabbit Fab |
| HPAB-0347-YJ-F(E) | Rat Anti-CD3E Recombinant Antibody (clone 1Ab); Fab Fragment | FC, WB, Inhib | Rat Fab |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-714 | Anti-CD3E Recombinant Antibody (Visilizumab) | FuncS, IF, Neut, ELISA, FC, IP, ICC | IgG2 |
| TAB-H52 | Anti-Human CD3E Recombinant Antibody (Otelixizumab) | FC, IP, ELISA, Neut, FuncS, IF, WB | IgG1 - lambda |
| TAB-420CQ | Anti-Human CD3E Recombinant Antibody (Visilizumab) | ELISA, IHC, FC, IP, IF, FuncS | IgG2, κ |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-019 | Anti-Human CD3 Recombinant Antibody (Muromonab-CD3) | FC, IP, ELISA, Neut, FuncS, IF, WB | IgG2a - kappa |
| PABX-032-S (P) | Recombinant Grey hamster Anti-CD3E Antibody scFv Fragment (2C11) | WB, ELISA, FuncS | scFv |
| PABX-033-S (P) | Recombinant Grey hamster Anti-CD3E Antibody scFv Fragment (17A2) | WB, ELISA, FuncS | scFv |
Immunotoxin
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-G010E | Anti-CD3E immunotoxin UCHT1 (scFv)-PE | Cytotoxicity assay, Function study | |
| AGTO-G010D | Anti-CD3E immunotoxin UCHT1 (scFv)-DT | Cytotoxicity assay, Function study | |
| AGTO-L049E | anti-CD3E immunotoxin UCHT1 (IgG)-PE | Cytotoxicity assay, Functional assay | |
| AGTO-L049D | anti-CD3E immunotoxin UCHT1 (IgG)-DT | Cytotoxicity assay, Functional assay | |
| AGTO-L049R | anti-CD3E immunotoxin UCHT1 (IgG)-RTA | Cytotoxicity assay, Functional assay |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-124CL | Human Anti-CD3E Recombinant Antibody (TAB-124CL) | ELISA | Human IgG |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-643 | Mouse Anti-CD3E Recombinant Antibody (clone 2C11); scFv Fragment | WB, IHC, IF, FuncS | Mouse scFv |
| FAMAB-0049-YC-S(P) | Hamster Anti-CD3E Recombinant Antibody (clone 145-2C11); scFv Fragment | FC, FuncS | Hamster scFv |
| FAMAB-0052-YC-S(P) | Hamster Anti-CD3E Recombinant Antibody (clone 500A2); scFv Fragment | ELISA | Hamster scFv |
| HPAB-0263-YJ-S(P) | Rabbit Anti-CD3E Recombinant Antibody (clone 645); scFv Fragment | ELISA, FC, FuncS | Rabbit scFv |
| HPAB-0385-FY-S(P) | Human Anti-CD3E Recombinant Antibody; scFv Fragment (HPAB-0385-FY-S(P)) | Activ | Human scFv |
Chimeric Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABX-032 | Recombinant Grey hamster Anti-CD3E Antibody (2C11) | WB, ELISA, FuncS, IP | IgG |
| PABX-033 | Recombinant Grey hamster Anti-CD3E Antibody (17A2) | WB, ELISA, FuncS | IgG |
| PABX-032-F (E) | Recombinant Grey hamster Anti-CD3E Antibody Fab Fragment (2C11) | WB, ELISA, FuncS | Fab |
| PABX-033-F (E) | Recombinant Grey hamster Anti-CD3E Antibody Fab Fragment (17A2) | WB, ELISA, FuncS | Fab |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0558 | Hi-Affi™ Rabbit Anti-CD3E Recombinant Antibody (clone DS558AB) | IHC-P | Rabbit IgG |
| MOR-0058-FY | Rabbit Anti-CD3E Recombinant Antibody (clone AFY0029) | FC, ICC, IF, IHC-P, WB | Rabbit IgG |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-1744-CN | Rabbit Anti-CD3E Polyclonal Antibody (MRO-1744-CN) | WB, IF, IHC, FC | Rabbit IgG |
| FN-201CQ | Hamster Anti-CD3E Recombinant Antibody (clone CBL-1334) | FC, FuncS, IHC-Fr | Syrian hamster IgG |
| HPAB-0385-FY | Human Anti-CD3E Recombinant Antibody (HPAB-0385-FY) | Activ | Human IgG1 |
| VS3-XY298 | Mouse Anti-CD3E Recombinant Antibody (clone 4E2) | ELISA, WB, FC | Mouse IgG1 |
| VS4-WK82 | Mouse Anti-CD3E Recombinant Antibody (VS4-WK82) | ELISA, IF, FC | Mouse IgG2a |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-245 | Afuco™ Anti-CD3E ADCC Recombinant Antibody (Foralumab), ADCC Enhanced | ELISA, FC, IP, FuncS, IF | ADCC enhanced antibody |
| AFC-TAB-H52 | Afuco™ Anti-CD3E ADCC Recombinant Antibody (Otelixizumab), ADCC Enhanced | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
| AFC-TAB-714 | Afuco™ Anti-CD3E ADCC Recombinant Antibody (Visilizumab), ADCC Enhanced | FuncS, IF, Neut, ELISA, FC, IP | ADCC enhanced antibody |
| AFC-TAB-019 | Afuco™ Anti-CD3E ADCC Recombinant Antibody (Muromonab-Cd3), ADCC Enhanced | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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