Afuco™ Anti-Human TNFSF14 ADCC Recombinant Antibody (SAR252067), ADCC Enhanced (CAT#: AFC-615CL)
Anti-TNFSF14 ADCC Enhanced Antibody (SAR252067) is an ADCC enhanced antibody produced by our Afuco™ platform. SAR 252067 is an anti-LIGHT fully human monoclonal antibody that is being developed for the treatment of ulcerative colitis and crohn's disease.
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Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line THP-1
(Immunofluorescent staining of human cell line THP-1 shows localization to vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12700/2061_E6_3_selected.jpg
(Immunofluorescent staining of human cell line THP-1 shows localization to vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12700/2061_E6_3_selected.jpg
Figure 2 IHC staining of human urinary bladder
(Immunohistochemical staining of human urinary bladder shows strong cytoplasmic positivity in umbrella cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12700/ihc_selected.jpg
(Immunohistochemical staining of human urinary bladder shows strong cytoplasmic positivity in umbrella cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12700/ihc_selected.jpg
Figure 3 Colon
(Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12700/57480_A_9_3.jpg
(Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12700/57480_A_9_3.jpg
Figure 4 Liver
(Cholangiocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12700/57480_A_9_4.jpg
(Cholangiocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12700/57480_A_9_4.jpg
Figure 5 Kidney
(Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12700/57480_A_8_5.jpg
(Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12700/57480_A_8_5.jpg
Figure 6 Testis
(Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12700/57480_A_4_6.jpg
(Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12700/57480_A_4_6.jpg
Figure 7 RNA cell line category: Cell line enhanced (HDLM-2, NB-4, THP-1, U-937)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000125735-TNFSF14
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000125735-TNFSF14
Specifications
- Host Species
- Human
- Derivation
- Human
- Type
- ADCC enhanced antibody
- Species Reactivity
- Human
- Applications
- FuncS
- Related Disease
- Autoimmune Diseases; Crohn's Disease; Ulcerative Colitis
Product Property
- Purity
- >90% assessed by SDS-PAGE
- Storage
- ≤6 months at 4°C; ≥6 months at -20°C.
Applications
- Application Notes
- The antibody was validated for Function Assay. For details, refer to Published Data.
Target
- Alternative Names
- TNFSF14; tumor necrosis factor (ligand) superfamily, member 14; LTg; TR2; CD258; HVEML; LIGHT; tumor necrosis factor ligand superfamily member 14; delta transmembrane LIGHT; herpesvirus entry mediator A; herpesvirus entry mediator ligand; herpesvirus entry mediator-ligand; herpes virus entry mediator ligand; ligand for herpesvirus entry mediator; tumor necrosis factor receptor-like 2; tumor necrosis factor superfamily member LIGHT
- Gene ID
- 8740
- UniProt ID
- O43557
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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Human Antibody Products
IgG Antibody Products
ScFv Antibody Products
Fab Antibody Products
Flow Cytometry (FC) related Reagents and Kits: Empowering Cell Function Research
Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-159CQ | Anti-Human TNFSF14 Recombinant Antibody (TR01G03) | ELISA, FC, WB | Human antibody |
| TAB-159CQ-S(P) | Anti-Human TNFSF14 Recombinant Antibody scFv Fragment (TR01G03) | ELISA, FC, WB | Human antibody |
| TAB-159CQ-F(E) | Anti-Human TNFSF14 Recombinant Antibody Fab Fragment (TR01G03) | ELISA, FC, WB | Human antibody |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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