Afuco™ Anti-Human TNFSF14 ADCC Recombinant Antibody (SAR252067), ADCC Enhanced (CAT#: AFC-615CL)
Anti-TNFSF14 ADCC Enhanced Antibody (SAR252067) is an ADCC enhanced antibody produced by our Afuco™ platform. SAR 252067 is an anti-LIGHT fully human monoclonal antibody that is being developed for the treatment of ulcerative colitis and crohn's disease.
Specific Inquiry
Figure 1 Mean serum concentration of SAR252067 with each dose over time, shown in (A) Cartesian plot (mean ± SD) and (B) semi-log plot.
Zhang, M., Perrin, L., & Pardo, P. (2017). A Randomized Phase 1 Study to Assess the Safety and Pharmacokinetics of the Subcutaneously Injected Anti‐LIGHT Antibody, SAR252067. Clinical pharmacology in drug development, 6(3), 292-301.
Figure 2 SAR252067 serum levels over the entire dose range, illustrated by (A) Cmax and (B) AUC0-∞.
Zhang, M., Perrin, L., & Pardo, P. (2017). A Randomized Phase 1 Study to Assess the Safety and Pharmacokinetics of the Subcutaneously Injected Anti‐LIGHT Antibody, SAR252067. Clinical pharmacology in drug development, 6(3), 292-301.
FuncS
Figure 3 Summary plots of individual sLIGHT values (mean ± SE) over time.
Zhang, M., Perrin, L., & Pardo, P. (2017). A Randomized Phase 1 Study to Assess the Safety and Pharmacokinetics of the Subcutaneously Injected Anti‐LIGHT Antibody, SAR252067. Clinical pharmacology in drug development, 6(3), 292-301.
Specifications
- Host Species
- Human
- Derivation
- Human
- Type
- ADCC enhanced antibody
- Species Reactivity
- Human
- Applications
- FuncS
- Related Disease
- Autoimmune Diseases; Crohn's Disease; Ulcerative Colitis
Product Property
- Purity
- >90% assessed by SDS-PAGE
- Storage
- ≤6 months at 4°C; ≥6 months at -20°C.
Applications
- Application Notes
- The antibody was validated for Function Assay. For details, refer to Published Data.
Target
- Alternative Names
- TNFSF14; tumor necrosis factor (ligand) superfamily, member 14; LTg; TR2; CD258; HVEML; LIGHT; tumor necrosis factor ligand superfamily member 14; delta transmembrane LIGHT; herpesvirus entry mediator A; herpesvirus entry mediator ligand; herpesvirus entry mediator-ligand; herpes virus entry mediator ligand; ligand for herpesvirus entry mediator; tumor necrosis factor receptor-like 2; tumor necrosis factor superfamily member LIGHT
- Gene ID
- 8740
- UniProt ID
- O43557
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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See other products for "TNFSF14"
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3612z | Mouse Anti-TNFSF14 Recombinant Antibody (clone 19G4) | WB, IP, IF, IHC, ELISA | Mouse IgG2a, κ |
| MOB-1093CT | Recombinant Mouse anti-Human TNFSF14 Monoclonal antibody (EML2020) | IHC-P, WB | |
| HPAB-N0404-YC | Human Anti-TNFSF14 Recombinant Antibody (HPAB-N0404-YC) | ELISA, FC, Inhib | Human IgG |
| HPAB-0847-CN | Human Anti-TNFSF14 Recombinant Antibody (clone h5E10) | ELISA, FC | Humanized IgG1, κ |
| HPAB-0848-CN | Human Anti-TNFSF14 Recombinant Antibody (clone h10D11) | ELISA, FC | Humanized IgG1, κ |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-159CQ | Anti-Human TNFSF14 Recombinant Antibody (TR01G03) | ELISA, FC, WB | Human antibody |
| TAB-159CQ-S(P) | Anti-Human TNFSF14 Recombinant Antibody scFv Fragment (TR01G03) | ELISA, FC, WB | Human antibody |
| TAB-159CQ-F(E) | Anti-Human TNFSF14 Recombinant Antibody Fab Fragment (TR01G03) | ELISA, FC, WB | Human antibody |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0404-YC-S(P) | Human Anti-TNFSF14 Recombinant Antibody; scFv Fragment (HPAB-N0404-YC-S(P)) | ELISA, FC, Inhib | Human scFv |
| HPAB-0106LY-S(P) | Human Anti-TNFSF14 Recombinant Antibody; scFv Fragment (HPAB-0106LY-S(P)) | ELISA, RIA, Block, FC | Human scfv |
| HPAB-0107LY-S(P) | Human Anti-TNFSF14 Recombinant Antibody; scFv Fragment (HPAB-0107LY-S(P)) | ELISA, RIA, Block, FC | Human scfv |
| HPAB-0108LY-S(P) | Human Anti-TNFSF14 Recombinant Antibody; scFv Fragment (HPAB-0108LY-S(P)) | ELISA, RIA, Block, FC | Human scfv |
| HPAB-0109LY-S(P) | Human Anti-TNFSF14 Recombinant Antibody; scFv Fragment (HPAB-0109LY-S(P)) | ELISA, RIA, Block, FC | Human scfv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0404-YC-F(E) | Human Anti-TNFSF14 Recombinant Antibody; Fab Fragment (HPAB-N0404-YC-F(E)) | ELISA, FC, Inhib | Human Fab |
| HPAB-0847-CN-F(E) | Human Anti-TNFSF14 Recombinant Antibody (clone h5E10); Fab Fragment | ELISA, FC | Humanized Fab |
| HPAB-0848-CN-F(E) | Human Anti-TNFSF14 Recombinant Antibody (clone h10D11); Fab Fragment | ELISA, FC | Humanized Fab |
| HPAB-0849-CN-F(E) | Human Anti-TNFSF14 Recombinant Antibody (clone h14G8); Fab Fragment | ELISA, FC | Humanized Fab |
| HPAB-0850-CN-F(E) | Human Anti-TNFSF14 Recombinant Antibody (clone h18B1); Fab Fragment | ELISA, FC | Humanized Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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