Afuco™ Anti-Human TNFSF14 ADCC Recombinant Antibody (SAR252067), ADCC Enhanced
CAT#: AFC-615CL
Anti-TNFSF14 ADCC Enhanced Antibody (SAR252067) is an ADCC enhanced antibody produced by our Afuco™ platform. SAR 252067 is an anti-LIGHT fully human monoclonal antibody that is being developed for the treatment of ulcerative colitis and crohn's disease.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line THP-1
Immunofluorescent staining of human cell line THP-1 shows localization to vesicles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/12700/2061_E6_3_selected.jpg
Normal Tissue
Figure 2 IHC staining of human urinary bladder
Immunohistochemical staining of human urinary bladder shows strong cytoplasmic positivity in umbrella cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/12700/ihc_selected.jpg
Normal Tissue
Figure 3 Colon
Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/12700/57480_A_9_3.jpg
Normal Tissue
Figure 4 Liver
Cholangiocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/12700/57480_A_9_4.jpg
Normal Tissue
Figure 5 Kidney
Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/12700/57480_A_8_5.jpg
Normal Tissue
Figure 6 Testis
Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/12700/57480_A_4_6.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enhanced (HDLM-2, NB-4, THP-1, U-937)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000125735-TNFSF14
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Specifications
- Host Species
- Human
- Derivation
- Human
- Type
- ADCC enhanced antibody
- Species Reactivity
- Human
- Applications
- FuncS
- Related Disease
- Autoimmune Diseases; Crohn's Disease; Ulcerative Colitis
Product Property
- Purity
- >90% assessed by SDS-PAGE
- Storage
- ≤6 months at 4°C; ≥6 months at -20°C.
Applications
- Application Notes
- The antibody was validated for Function Assay. For details, refer to Published Data.
Target
- Alternative Names
- TNFSF14; tumor necrosis factor (ligand) superfamily, member 14; LTg; TR2; CD258; HVEML; LIGHT; tumor necrosis factor ligand superfamily member 14; delta transmembrane LIGHT; herpesvirus entry mediator A; herpesvirus entry mediator ligand; herpesvirus entry mediator-ligand; herpes virus entry mediator ligand; ligand for herpesvirus entry mediator; tumor necrosis factor receptor-like 2; tumor necrosis factor superfamily member LIGHT
- Gene ID
- 8740
- UniProt ID
- O43557
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-159CQ | Anti-Human TNFSF14 Recombinant Antibody (TR01G03) | ELISA, FC, WB | Human antibody |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1093CT | Recombinant Mouse anti-Human TNFSF14 Monoclonal antibody (EML2020) | IHC-P, WB | |
| HPAB-0847-CN | Human Anti-TNFSF14 Recombinant Antibody (clone h5E10) | ELISA, FC | Humanized IgG1, κ |
| HPAB-0848-CN | Human Anti-TNFSF14 Recombinant Antibody (clone h10D11) | ELISA, FC | Humanized IgG1, κ |
| HPAB-0849-CN | Human Anti-TNFSF14 Recombinant Antibody (clone h14G8) | ELISA, FC | Humanized IgG1, κ |
| VS3-FY2770 | Mouse Anti-TNFSF14 Recombinant Antibody (VS3-FY2770) | WB, IHC, FC, ELISA | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0404-YC-F(E) | Human Anti-TNFSF14 Recombinant Antibody; Fab Fragment (HPAB-N0404-YC-F(E)) | ELISA, FC, Inhib | Human Fab |
| HPAB-0847-CN-F(E) | Human Anti-TNFSF14 Recombinant Antibody (clone h5E10); Fab Fragment | ELISA, FC | Humanized Fab |
| HPAB-0848-CN-F(E) | Human Anti-TNFSF14 Recombinant Antibody (clone h10D11); Fab Fragment | ELISA, FC | Humanized Fab |
| HPAB-0849-CN-F(E) | Human Anti-TNFSF14 Recombinant Antibody (clone h14G8); Fab Fragment | ELISA, FC | Humanized Fab |
| HPAB-0850-CN-F(E) | Human Anti-TNFSF14 Recombinant Antibody (clone h18B1); Fab Fragment | ELISA, FC | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0106LY-S(P) | Human Anti-TNFSF14 Recombinant Antibody; scFv Fragment (HPAB-0106LY-S(P)) | ELISA, RIA, Block, FC | Human scfv |
| HPAB-0107LY-S(P) | Human Anti-TNFSF14 Recombinant Antibody; scFv Fragment (HPAB-0107LY-S(P)) | ELISA, RIA, Block, FC | Human scfv |
| HPAB-0108LY-S(P) | Human Anti-TNFSF14 Recombinant Antibody; scFv Fragment (HPAB-0108LY-S(P)) | ELISA, RIA, Block, FC | Human scfv |
| HPAB-0109LY-S(P) | Human Anti-TNFSF14 Recombinant Antibody; scFv Fragment (HPAB-0109LY-S(P)) | ELISA, RIA, Block, FC | Human scfv |
| HPAB-0110LY-S(P) | Human Anti-TNFSF14 Recombinant Antibody; scFv Fragment (HPAB-0110LY-S(P)) | ELISA, RIA, Block, FC | Human scfv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS13-YC1170 | CytoStream™ Rabbit Anti-TNFSF14 Recombinant Antibody (VS13-YC1170) | FC, ELISA | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC484 | Recombinant Anti-TNFSF14 Vesicular Antibody, EV Displayed (VS-0425-YC484) | Block, ELISA, FC, Cell-uptake |
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