Eculizumab (CAT#: TP-092CL)

Soliris is a formulation of eculizumab which is a recombinant humanized monoclonal IgG2/4;κ antibody produced by murine myeloma cell culture and purified by standard bioprocess technology. Eculizumab contains human constant regions from human IgG2 sequences and human IgG4 sequences and murine complementarity-determining regions grafted onto the human framework light- and heavy-chain variable regions. Eculizumab is composed of two 448 amino acid heavy chains and two 214 amino acid light chains and has a molecular weight of approximately 148 kDa.

Isotype: Biotech

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Datasheet
MSDS
COA

Datasheet

MSDS

Certificate of Analysis Lookup
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Lot Number

Specifications

Type
Biotech

Trade name
Soliris

UNII
A3ULP0F556

Target

Function
Humanized mAb that binds complement protein C5 and inhibits its cleavage to C5a and C5b, preventing the formation of the terminal complement complex C5b–9

Related Resources

Biosimilar Overview

Please refer to Eculizumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Eculizumab.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

* Abbreviations

3D IHC3D Immunohistochemistry

AgonistAgonist

BABioassay

Cell ScreeningCell Screening

SeparationCell Separation

ChIPChromatin Immunoprecipitation

CMCDComplement Mediated Cell Depletion