AI-based High Throughput Antibody Fc Engineering Service
At our high throughput antibody production service, Creative Biolabs leverages artificial intelligence (AI) to enhance antibody Fc engineering for improved therapeutic outcomes. Our state-of-the-art platform enables rapid screening and selection of antibodies with optimized Fc regions for enhanced functionality, such as improved antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC) activity.
Antibody Fc Engineering
Antibody Fc engineering refers to the process of modifying the Fc region of an antibody molecule to enhance its biological functions or properties. This can involve changes to the Fc region's structure, glycosylation pattern, or affinity for Fc receptors on immune cells, among other modifications. The goal of antibody Fc engineering is to generate antibodies with improved therapeutic efficacy, such as increased potency, longer half-life, or enhanced effector functions.
Featured Antibody Fc Engineering Platform Based AI at Creative Biolabs
Our team of experts will work closely with you to design and execute customized antibody engineering strategies, using our scalable production platform to generate large quantities of high-quality antibodies for further evaluation. With our high-throughput approach, we can quickly identify lead candidates with superior Fc properties, saving you time and resources in the drug development process.
Antibody Fc Engineering Strategies
Antibody Fc engineering is a field within biotechnology that focuses on manipulating the fragment crystallizable (Fc) region of antibodies to enhance their therapeutic properties and functions. Creative Biolabs provides antibody Fc engineering services that can assist in the design, optimization, and characterization of engineered antibodies for various applications in biotechnology and medicine.
Fc glycoengineering
This involves modifying the glycan structure attached to the Fc region of antibodies to enhance their effector functions, such as antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC).
Fc receptor engineering
By modifying the Fc region to increase its affinity for certain Fc receptors on immune cells, the antibody can more effectively engage with these receptors and elicit an immune response.
Fc fusion proteins
Antibodies can be engineered to have a fusion protein attached to their Fc region, which can extend their half-life in circulation or target specific cell types or tissues.
Fc domain swapping
By exchanging the Fc region of one antibody with the Fc region of another antibody, novel antibodies with unique characteristics and functions are created.
Process of Our Service
The high throughput antibody production service for AI-based Fc engineering involves a systematic process of antibody selection, variant generation, screening, characterization, production, quality control, and final delivery. We use artificial intelligence to optimize antibody production processes, increasing efficiency and throughput for engineering Fc domains.
01
Generation of initial antibody variants
Once the target antibody is selected, a library of antibody variants is generated using various techniques such as phage display or yeast display.
02
Characterization of selected candidates
The selected Fc-engineered antibody candidates are further characterized to assess their stability, specificity, and functionality.
03
Quality control and validation
The Fc-engineered antibodies undergo rigorous quality control testing to ensure their safety and efficacy.
04
Selection of antibody target
The first step is the selection of the target antibody to be engineered.
05
Screening for Fc engineering candidates
The generated antibody variants are then screened for desired Fc engineering characteristics such as improved binding affinity, enhanced effector functions, or reduced immunogenicity. High throughput screening assays are used to quickly identify promising candidates.
06
Scale-up production
This step involves large-scale cell culture, purification, and formulation of the antibodies.
07
Delivery of engineered antibodies
Delivery of the Fc-engineered antibodies to the customer for their intended use.
Advantages of Our Service
Customized Antibody Production
High throughput antibody production services can provide a large number of fully customized antibodies for AI-based Fc engineering projects.
Speed and Efficiency
High throughput antibody production services can rapidly produce large quantities of antibodies, reducing the time needed for screening and selection of optimal candidates for further engineering.
Increased Success Rate
The ability to produce a large number of antibodies simultaneously increases the likelihood of finding high-affinity antibodies with the desired Fc engineering properties, leading to a higher success rate in antibody development projects.
Expertise and Support
Creative Biolabs has experienced scientists who provide guidance and support throughout the antibody production process, from design to characterization.
Scalability
High throughput antibody production services can easily scale up production to meet the demand for large quantities of antibodies, making it suitable for projects that require a high volume of antibodies for screening and optimization.
Cooperation With Creative Biolabs
Contact Us
Whether you are looking to enhance the efficacy of an existing antibody or develop novel therapeutics with improved Fc functionality, our high throughput antibody production service can help you achieve your goals efficiently and effectively. Contact us now to learn more about how we can support your antibody engineering needs.
For research use only. Not intended for any clinical use.
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