Mouse Anti-ADGRG1 Recombinant Antibody (VS3-FY2621) (CAT#: VS3-FY2621)

• Host Species
• Mouse

• Type
• Mouse IgG

• Specificity
• Adhesion G protein-coupled receptor G1 of human

• Species Reactivity
• Human

• Applications
• IHC, FC, ELISA

• Conjugate
• Unconjugated, FITC

• MW
• The molecular weight of the target protein is approximately 77.7 kDa.

• Related Disease
• Cortical Dysplasia, Complex, With Other Brain Malformations 14A and Cortical Dysplasia, Complex, With Other Brain Malformations 14B

• Clonality
• Monoclonal Antibody

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.

• Application Notes
• Immunohistochemistry: 1/50-1/200
  Flow cytometry: 1/50-1/200
  ELISA: 1/1000-1/10000

• Alternative Names
• Adhesion G Protein-Coupled Receptor G1; G Protein-Coupled Receptor 56; G-Protein Coupled Receptor 56; TM7LN4; TM7XN1; GPR56; 7-Transmembrane Protein With No EGF-Like N-Terminal Domains-1

• Gene ID
• 9289

• Sequence Similarities
• Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.

• Cellular Localization
• Cell membrane

• Post Translation Modifications
• Autoproteolytically cleaved into 2 fragments; the large extracellular N-terminal fragment (ADGRG1 NT) and the membrane-bound C-terminal fragment (ADGRG1 CT) predominantly remain associated and non-covalently linked.
  Shedding to yield the secreted ADGRG1 N-terminal fragment seems to involve metalloprotease(s).
  N-glycosylated.
  Contains sialic acid residues.
  Ubiquitinated.

• Protein Refseq
• XP_005256294.1; XP_005256295.1; XP_005256296.1; XP_005256297.1; XP_005256298.1

• Function
• Mediates cell matrix adhesion in developing neurons and hematopoietic stem cells.
  Receptor for collagen III/COL3A1 in the developing brain and involved in regulation of cortical development, specifically in maintenance of the pial basement membrane integrity and in cortical lamination (By similarity).
  Binding to the COL3A1 ligand inhibits neuronal migration and activates the RhoA pathway by coupling to GNA13 and possibly GNA12 (PubMed:22238662).
  Plays a role in the maintenance of hematopoietic stem cells and/or leukemia stem cells in bone marrow niche (By similarity).
  Plays a critical role in cancer progression by inhibiting VEGFA production threreby inhibiting angiogenesis through a signaling pathway mediated by PRKCA (PubMed:16757564, 21724588).
  Plays an essential role in testis development (By similarity).

Secondary Antibody

• 2ND-040CQ
• Goat Anti-Mouse IgG (H&L) Antibody

Isotype Control

• MRO-A1591-YJ
• Mouse IgG Isotype control, Polyclonal

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