Human Anti-CD4 Recombinant Antibody Hexamer (VS-0924-YC115), CDC Enhanced (CAT#: VS-0924-YC115)
The product is a human anti-CD4 antibody hexamer designed with enhanced complement-dependent cytotoxicity (CDC) activity. This hexameric IgG1 targets human CD4 and includes mutations that enhance hexamerization, promoting optimal C1q binding and improved CDC.
Specific Inquiry
Subcellular Location
RNA Expression
Figure 1 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/11/if_selected.jpg
(Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/11/if_selected.jpg
Figure 2 RNA cell line category: Group enriched (HEL, HL-60, NB-4, THP-1, U-937)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000010610-CD4
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000010610-CD4
Figure 2 RNA cell line category: Group enriched (HEL, HL-60, NB-4, THP-1, U-937)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000010610-CD4
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000010610-CD4
Specifications
- Host Species
- Human
- Derivation
- Chimeric (rat/human)
- Type
- Antibody hexamer
- Specificity
- Human CD4
- Species Reactivity
- Human
- Molecule Class
- ~ 900 kDa
- Applications
- ELISA, FC, ADCC, CDC, SPR
- Conjugate
- None
- Related Disease
- Cancer, Immune disease
Product Property
- Clonality
- Monoclonal
- Purification
- Protein A purified
- Purity
- >95% determined as SDS-PAGE and SEC-HPLC
- Aggregation
- <5%
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C short term (1-2 weeks). Store at -20°C long term (12 months). Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- CD4mut; CD4
- Gene ID
- 920
- UniProt ID
- P01730
- Long Name
- CD4 Molecule
- Sequence Similarities
- The Ig-like V-type domain mediates the interaction with MHCII.
- Post Translation Modifications
- Palmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts. ( P01730-CD4_HUMAN )
Phosphorylated by PKC; phosphorylation at Ser-433 plays an important role for CD4 internalization. ( P01730-CD4_HUMAN )
Glycosylation at Asn296 and Asn325 ( NX_P01730 [NX_P01730-1] )
Ubiquitination at Lys453 ( NX_P01730 [NX_P01730-1] )
Related Resources
Primary Immunodeficiency
Downloads
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|---|---|---|---|
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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