Recombinant Anti-CD4 (Domain 1 x Domain 2) Biparatopic Antibody, Tandem scFv
CAT#: VS-0525-YC204
The Recombinant Anti-CD4 (Domain 1 x Domain 2) Biparatopic Antibody, Tandem scFv is a biparatopic antibody (bpAb) designed to engage two distinct CD4 epitopes. This construct features tandem scFv arms. These arms simultaneously bind with high affinity to domain 1 and domain 2 of CD4.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/11/if_selected.jpg
RNA Expression
Figure 2 RNA cell line category: Group enriched (HEL, HL-60, NB-4, THP-1, U-937)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000010610-CD4
❮
❯
Specifications
- Host Animal 1
- Human
- Host Animal 2
- Mouse
- Specificity
- Human CD4
- Species Reactivity
- Human
- Type
- Tandem scFv
- Valency
- 1 + 1
- Epitope 1
- Domain 1 of CD4
- Epitope 2
- Domain 2 of CD4
- Purity
- >90%
- Purification
- Affinity purified
- Applications
- ELISA, FC, ICC, IF, IP, Neut
- Concentration
- Lot specific
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid freeze-thaw cycles.
- Long Name
- CD4 Molecule
Target
- Introduction
- Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts.
- Alternative Names
- Keliximab; 174722-30-6; IDEC CE9.1; SB210396; CD4; CD4 molecule; CD4 antigen (p55), T cell surface glycoprotein CD4; T-cell surface glycoprotein CD4; CD4 receptor; CD4 antigen (p55); T-cell surface antigen T4/Leu-3; CD4mut;
- Gene ID
- 920
- UniProt ID
- P01730
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Related Diseases
Primary Immunodeficiency
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
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