Recombinant monoclonal antibody to CD4. IgA F425-Alg8 is a mouse monoclonal antibody that can be potentially used in the treatment of viral infection.
Figure 1 The immunoreactivity of F425Alg8 IgGl and IgAl variants with HIV-infected cells.
SF-2 infected cells (1 x 10⁶) were incubated with titered Abs of F425Alg8 (black squares) and IgAl (black triangles), which were detected using HRP- conjugated goat anti-human IgG or IgA. Bound Ab was visualized using tetramethylbenzidine substrate and stopped by 100 microliters of 1M phosphoric acid. The OD was read on a plate reader at 450 nm. bl2 IgGl or IgAl (20 micorgram/ml) was a standard to determine relative activity of the F425Alg8 variants with HIV.
Figure 2 The neutralization activity of F425-Alg8 IgGl and IgAl antibody variants against HIV (JR-FL) measured using TZM-bl cells.
JR-FL (100 TCID50) was incubated with two-fold serial dilutions of F425Alg8 IgGl (open diamond) and IgAl (black square) variants prior to addition of TZM-bl cells. HIV was measured as beta-galactosidase activity after 48 h. Percent neutralization was determined by the formula [(control- test)/control] x 100.
Figure 3 Antibody-dependent cell mediated viral inhibition (ADCVI) mediated by F425-A18 IgAl and IgG antibody variants measured using HIV (JR-FL) infected peripheral blood mononuclear cells (PBMC).
ADCVI mediated by F425Alg8 IgGl (grey squares) and IgAl (black diamonds) antibodies and neutrophils. F425Alg8 variants were incubated with JR-FL-infected PBMCs just prior to adding neutrophils at an E:T ratio of 10: 1. After 4 h, PH A- stimulated PBMCs were added as indicator cells, and p24 was quantitated by ELISA after 1 wk. Percent inhibition was determined by the following formula: [(p24 control - p24 test)/p24 control] x 100.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Download resources about recombinant antibody development and antibody engineering to boost your research.
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-039 | Anti-Human CD4 Recombinant Antibody (Zanolimumab) | Neut, ELISA, IF, IP, FuncS, FC, IHC | IgG1 - kappa |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-164 | Anti-Human CD4 Recombinant Antibody (Priliximab) | WB, FuncS, IF, Neut, ELISA, FC, IP | IgG1 - kappa |
TAB-171 | Anti-Human CD4 Recombinant Antibody (Keliximab) | FuncS, IF, Neut, ELISA, FC, IP, ICC | IgG1 - lambda |
TAB-732 | Anti-CD4 Recombinant Antibody (Clenoliximab) | IF, IP, Neut, FuncS, ELISA, FC, ICC | IgG4 - lambda |
TAB-162LC-S(P) | Anti-Human CD4 Recombinant Antibody scFv Fragment | ELISA | Chimeric antibody (mouse/human) |
TAB-170LC-F(E) | Human Anti-CD4 Recombinant Antibody; Fab Fragment (TAB-170LC-F(E)) | ELISA, SPR | Chimeric antibody (rat/human) |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-146 | Anti-Human CD4 Recombinant Antibody (Ibalizumab) | FuncS, IF, Neut, ELISA, FC, IP, ICC | IgG4 - kappa |
TAB-161LC | Anti-Human CD4 Recombinant Antibody (gOKT4A-4) | ELISA | Humanized antibody |
TAB-168LC | Anti-Human CD4 Recombinant Antibody (TRX1) | ELISA | Humanized antibody |
TAB-171LC | Human Anti-CD4 Recombinant Antibody (TAB-171LC) | ELISA, FC, SPR | Humanized antibody |
TAB-172LC | Human Anti-CD4 Recombinant Antibody (TAB-172LC) | ELISA, Inhib | Human IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
AGTO-G078E | Anti-CD4 immunotoxin M-T151 (IgG)-PE | Cytotoxicity assay, Function study | |
AGTO-G078R | Anti-CD4 immunotoxin M-T151 (IgG)-RTA | Cytotoxicity assay, Function study |
CAT | Product Name | Application | Type |
---|---|---|---|
PFBL-033 | Human Anti-CD4 Recombinant Antibody (clone 17b); Fab Fragment | WB, ELISA, FuncS | Human Fab |
PFBL-034 | Mouse Anti-CD4 Recombinant Antibody (clone 2D5); Fab Fragment | Neut, ELISA, FuncS | Mouse Fab |
PFBL-035 | Mouse Anti-CD4 Recombinant Antibody (clone Q425); Fab Fragment | WB, ELISA, FuncS | Mouse Fab |
FAMAB-0054-YC-F(E) | Mouse Anti-CD4 Recombinant Antibody (clone M-T310); Fab Fragment | Neut | Mouse Fab |
FAMAB-0055-YC-F(E) | Mouse Anti-CD4 Recombinant Antibody (clone M-T404); Fab Fragment | Neut | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-160LC | Anti-Human CD4 Recombinant Antibody (OKT4A) | ELISA, WB | |
TAB-166LC | Anti-Human CD4 Recombinant Antibody (M-T412) | ELISA, Inhib | |
TAB-174LC | Mouse Anti-CD4 Recombinant Antibody (TAB-174LC) | ELISA, FC, IHC, Neut, FuncS | Mouse IgG1 |
TAB-175LC | Anti-Human CD4 Recombinant Antibody (15A7) | ELISA, FC, IF, WB, Inhib | |
TAB-176LC | Anti-Human CD4 Recombinant Antibody (14G7) | FC, ELISA, IF, Block |
CAT | Product Name | Application | Type |
---|---|---|---|
Gly-025LC | Recombinant Anti-Human CD4 Antibody (Fab glycosylation) | ELISA | Humanized antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-351CQ | Mouse Anti-CD4 Recombinant Antibody (clone 10C12) | ELISA, WB, IF, Block | Mouse IgG1 |
NEUT-352CQ | Mouse Anti-CD4 Recombinant Antibody (clone 13B8.2) | Block, ELISA, FC, IHC-Fr, WB | Mouse IgG1, κ |
NEUT-355CQ | Mouse Anti-CD4 Recombinant Antibody (clone RPA-T4) | FC, CyTOF, Block, IHC | Mouse IgG1, κ |
NEUT-357CQ | Rat Anti-CD4 Recombinant Antibody (clone MAB0810) | Block, Depletion, Stim | Rat IgG2b |
NEUT-358CQ | Rat Anti-CD4 Recombinant Antibody (clone RM4-5) | FC, CyTOF, Depletion, Block, IHC | Rat IgG2a, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-353CQ | Mouse Anti-CD4 Recombinant Antibody (clone CBL976) | FC, Neut, IF, IHC | Mouse IgG1, κ |
NEUT-354CQ | Recombinant Mouse Anti-CD4 Antibody (CT-4) | Neut, FC, IHC, IHC-Fr, IHC-P, IP | IgG1, κ |
NEUT-356CQ | Mouse Anti-CD4 Recombinant Antibody (clone 3-4F4) | Neut, FC, IHC, IHC-Fr, IP, ICC | Mouse IgG1, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-0560 | Hi-Affi™ Rabbit Anti-CD4 Recombinant Antibody (clone DS560AB) | IHC-P | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
FAMAB-0054YC | Mouse Anti-CD4 Recombinant Antibody (clone M-T310) | Neut | Mouse IgG1, κ |
FAMAB-0055YC | Mouse Anti-CD4 Recombinant Antibody (clone M-T404) | Neut | Mouse IgG1, κ |
FAMAB-0056YC | Mouse Anti-CD4 Recombinant Antibody (clone M-T408) | Neut | Mouse IgG1, κ |
FAMAB-0057YC | Mouse Anti-CD4 Recombinant Antibody (clone M-T151) | Neut | Mouse IgG2a, κ |
HPAB-0302LY | Human Anti-CD4 Recombinant Antibody (clone TNX-355) | ELISA | Humanized IgG4 |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-039 | Afuco™ Anti-CD4 ADCC Recombinant Antibody (Zanolimumab), ADCC Enhanced | Neut, ELISA, IF, IP, FuncS, FC | ADCC enhanced antibody |
AFC-TAB-164 | Afuco™ Anti-CD4 ADCC Recombinant Antibody (Priliximab), ADCC Enhanced | FuncS, IF, Neut, ELISA, FC | ADCC enhanced antibody |
AFC-TAB-260 | Afuco™ Anti-CD4 ADCC Recombinant Antibody (Tregalizumab), ADCC Enhanced | ELISA, FC, IP, FuncS, IF | ADCC enhanced antibody |
AFC-TAB-171 | Afuco™ Anti-CD4 ADCC Recombinant Antibody (Keliximab), ADCC Enhanced | FuncS, IF, Neut, ELISA, FC, IP | ADCC enhanced antibody |
AFC-TAB-107 | Afuco™ Anti-CD4 ADCC Recombinant Antibody (Cedelizumab), ADCC Enhanced | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-J0046-YC-S(P) | Rat Anti-CD4 Recombinant Antibody; scFv Fragment (HPAB-J0046-YC-S(P)) | ELISA, FC, CDC | Rat scFv |
HPAB-J0047-YC-S(P) | Human Anti-CD4 Recombinant Antibody; scFv Fragment (HPAB-J0047-YC-S(P)) | ELISA, FC, ADCC, CDC | Rat scFv |
HPAB-J0048-YC-S(P) | Human Anti-CD4 Recombinant Antibody; scFv Fragment (HPAB-J0048-YC-S(P)) | ELISA, FC, ADCC, CDC | Rat scFv |
HPAB-J0049-YC-S(P) | Human Anti-CD4 Recombinant Antibody; scFv Fragment (HPAB-J0049-YC-S(P)) | ELISA, FC, ADCC, CDC | Rat scFv |
HPAB-2112-FY-S(P) | Mouse Anti-CD4 Recombinant Antibody (clone MT15.1); scFv Fragment | Inhib | Mouse scFv |
There are currently no Customer reviews or questions for TAB-173LC. Click the button above to contact us or submit your feedback about this product.
View the frequently asked questions answered by Creative Biolabs Support.
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.