Anti-Human CD4 Recombinant Antibody (IgA F425-Alg8) (CAT#: TAB-173LC)

Recombinant monoclonal antibody to CD4. IgA F425-Alg8 is a mouse monoclonal antibody that can be potentially used in the treatment of viral infection.


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  • Published Data
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
ELISA

Figure 1 The immunoreactivity of F425Alg8 IgGl and IgAl variants with HIV-infected cells.

Figure 1 The immunoreactivity of F425Alg8 IgGl and IgAl variants with HIV-infected cells.

SF-2 infected cells (1 x 10⁶) were incubated with titered Abs of F425Alg8 (black squares) and IgAl (black triangles), which were detected using HRP- conjugated goat anti-human IgG or IgA. Bound Ab was visualized using tetramethylbenzidine substrate and stopped by 100 microliters of 1M phosphoric acid. The OD was read on a plate reader at 450 nm. bl2 IgGl or IgAl (20 micorgram/ml) was a standard to determine relative activity of the F425Alg8 variants with HIV.

Neut

Figure 2 The neutralization activity of F425-Alg8 IgGl and IgAl antibody variants against HIV (JR-FL) measured using TZM-bl cells.

Figure 2 The neutralization activity of F425-Alg8 IgGl and IgAl antibody variants against HIV (JR-FL) measured using TZM-bl cells.

JR-FL (100 TCID50) was incubated with two-fold serial dilutions of F425Alg8 IgGl (open diamond) and IgAl (black square) variants prior to addition of TZM-bl cells. HIV was measured as beta-galactosidase activity after 48 h. Percent neutralization was determined by the formula [(control- test)/control] x 100.

Inhib

Figure 3 Antibody-dependent cell mediated viral inhibition (ADCVI) mediated by F425-A18 IgAl and IgG antibody variants measured using HIV (JR-FL) infected peripheral blood mononuclear cells (PBMC).

Figure 3 Antibody-dependent cell mediated viral inhibition (ADCVI) mediated by F425-A18 IgAl and IgG antibody variants measured using HIV (JR-FL) infected peripheral blood mononuclear cells (PBMC).

ADCVI mediated by F425Alg8 IgGl (grey squares) and IgAl (black diamonds) antibodies and neutrophils. F425Alg8 variants were incubated with JR-FL-infected PBMCs just prior to adding neutrophils at an E:T ratio of 10: 1. After 4 h, PH A- stimulated PBMCs were added as indicator cells, and p24 was quantitated by ELISA after 1 wk. Percent inhibition was determined by the following formula: [(p24 control - p24 test)/p24 control] x 100.


Specifications

  • Host Species
  • Mouse
  • Specificity
  • Human
  • Clone
  • IgA F425-Alg8
  • Applications
  • ELISA, Inhib
  • Related Disease
  • Viral infection

Applications

  • Application Notes
  • This antibody has been tested for use in Enzyme-linked Immunosorbent Assay and Inhibition. Please see the Published Data for further information.

Target

  • Alternative Names
  • CD4mut; CD4

Related Resources

  • Related Diseases

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

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Human Antibody

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Chimeric Antibody

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Humanized Antibody

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TAB-161LC Anti-Human CD4 Recombinant Antibody (gOKT4A-4) ELISA Humanized antibody
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TAB-171LC Human Anti-CD4 Recombinant Antibody (TAB-171LC) ELISA, FC, SPR Humanized antibody
TAB-172LC Human Anti-CD4 Recombinant Antibody (TAB-172LC) ELISA, Inhib Human IgG

Immunotoxin

CAT Product Name Application Type
AGTO-G078E Anti-CD4 immunotoxin M-T151 (IgG)-PE Cytotoxicity assay, Function study
AGTO-G078R Anti-CD4 immunotoxin M-T151 (IgG)-RTA Cytotoxicity assay, Function study

Fab Glycosylation

CAT Product Name Application Type
Gly-025LC Recombinant Anti-Human CD4 Antibody (Fab glycosylation) ELISA Humanized antibody

Blocking Antibody

CAT Product Name Application Type
NEUT-351CQ Mouse Anti-CD4 Recombinant Antibody (clone 10C12) ELISA, WB, IF, Block Mouse IgG1
NEUT-352CQ Mouse Anti-CD4 Recombinant Antibody (clone 13B8.2) Block, ELISA, FC, IHC-Fr, WB Mouse IgG1, κ
NEUT-355CQ Mouse Anti-CD4 Recombinant Antibody (clone RPA-T4) FC, CyTOF, Block, IHC Mouse IgG1, κ
NEUT-357CQ Rat Anti-CD4 Recombinant Antibody (clone MAB0810) Block, Depletion, Stim Rat IgG2b
NEUT-358CQ Rat Anti-CD4 Recombinant Antibody (clone RM4-5) FC, CyTOF, Depletion, Block, IHC Rat IgG2a, κ

Neutralizing Antibody

CAT Product Name Application Type
NEUT-353CQ Mouse Anti-CD4 Recombinant Antibody (clone CBL976) FC, Neut, IF, IHC Mouse IgG1, κ
NEUT-354CQ Recombinant Mouse Anti-CD4 Antibody (CT-4) Neut, FC, IHC, IHC-Fr, IHC-P, IP IgG1, κ
NEUT-356CQ Mouse Anti-CD4 Recombinant Antibody (clone 3-4F4) Neut, FC, IHC, IHC-Fr, IP, ICC Mouse IgG1, κ

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-0560 Hi-Affi™ Rabbit Anti-CD4 Recombinant Antibody (clone DS560AB) IHC-P Rabbit IgG

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-039 Afuco™ Anti-CD4 ADCC Recombinant Antibody (Zanolimumab), ADCC Enhanced Neut, ELISA, IF, IP, FuncS, FC ADCC enhanced antibody
AFC-TAB-164 Afuco™ Anti-CD4 ADCC Recombinant Antibody (Priliximab), ADCC Enhanced FuncS, IF, Neut, ELISA, FC ADCC enhanced antibody
AFC-TAB-260 Afuco™ Anti-CD4 ADCC Recombinant Antibody (Tregalizumab), ADCC Enhanced ELISA, FC, IP, FuncS, IF ADCC enhanced antibody
AFC-TAB-171 Afuco™ Anti-CD4 ADCC Recombinant Antibody (Keliximab), ADCC Enhanced FuncS, IF, Neut, ELISA, FC, IP ADCC enhanced antibody
AFC-TAB-107 Afuco™ Anti-CD4 ADCC Recombinant Antibody (Cedelizumab), ADCC Enhanced IF, IP, Neut, FuncS, ELISA, FC ADCC enhanced antibody

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