Anti-Human CD4 Recombinant Antibody (IgA F425-Alg8) (CAT#: TAB-173LC)
Recombinant monoclonal antibody to CD4. IgA F425-Alg8 is a mouse monoclonal antibody that can be potentially used in the treatment of viral infection.
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Custom Production
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
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ELISA
Figure 1 The immunoreactivity of F425Alg8 IgGl and IgAl variants with HIV-infected cells.
SF-2 infected cells (1 x 10⁶) were incubated with titered Abs of F425Alg8 (black squares) and IgAl (black triangles), which were detected using HRP- conjugated goat anti-human IgG or IgA. Bound Ab was visualized using tetramethylbenzidine substrate and stopped by 100 microliters of 1M phosphoric acid. The OD was read on a plate reader at 450 nm. bl2 IgGl or IgAl (20 micorgram/ml) was a standard to determine relative activity of the F425Alg8 variants with HIV.
Neut
Figure 2 The neutralization activity of F425-Alg8 IgGl and IgAl antibody variants against HIV (JR-FL) measured using TZM-bl cells.
JR-FL (100 TCID50) was incubated with two-fold serial dilutions of F425Alg8 IgGl (open diamond) and IgAl (black square) variants prior to addition of TZM-bl cells. HIV was measured as beta-galactosidase activity after 48 h. Percent neutralization was determined by the formula [(control- test)/control] x 100.
Inhib
Figure 3 Antibody-dependent cell mediated viral inhibition (ADCVI) mediated by F425-A18 IgAl and IgG antibody variants measured using HIV (JR-FL) infected peripheral blood mononuclear cells (PBMC).
ADCVI mediated by F425Alg8 IgGl (grey squares) and IgAl (black diamonds) antibodies and neutrophils. F425Alg8 variants were incubated with JR-FL-infected PBMCs just prior to adding neutrophils at an E:T ratio of 10: 1. After 4 h, PH A- stimulated PBMCs were added as indicator cells, and p24 was quantitated by ELISA after 1 wk. Percent inhibition was determined by the following formula: [(p24 control - p24 test)/p24 control] x 100.
Specifications
- Host Species
- Mouse
- Specificity
- Human
- Clone
- IgA F425-Alg8
- Applications
- ELISA, Inhib
- Related Disease
- Viral infection
Applications
- Application Notes
- This antibody has been tested for use in Enzyme-linked Immunosorbent Assay and Inhibition. Please see the Published Data for further information.
Target
Related Resources
Primary Immunodeficiency
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-039 | Anti-Human CD4 Recombinant Antibody (Zanolimumab) | Neut, ELISA, IF, IP, FuncS, FC, IHC | IgG1 - kappa |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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