Mouse Anti-CD4 Recombinant Antibody Hexamer (VS-0924-YC116), CDC Enhanced

Name: Mouse Anti-CD4 Recombinant Antibody Hexamer (VS-0924-YC116), CDC Enhanced
SKU: VS-0924-YC116
Rating: 5 (1 reviews)

CAT#: VS-0924-YC116

The product is a mouse anti-CD4 antibody hexamer that exhibits enhanced complement-dependent cytotoxicity (CDC) activity. This hexameric IgG1 targets human CD4 and includes mutations that promote hexamerization, facilitating optimal C1q binding and thereby enhancing CDC.

Gene Expression

Subcellular Location Figure 1 IF staining of human cell line U-251 MG

Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/11/if_selected.jpg

RNA Expression Figure 2 RNA cell line category: Group enriched (HEL, HL-60, NB-4, THP-1, U-937)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000010610-CD4

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Specifications

Immunogen
Human CD4 peptide, RFLPADQMNVADPQPLASCS

Host Species
Mouse

Type
Antibody hexamer

Specificity
Human CD4

Species Reactivity
Human

Molecule Class
~ 900 kDa

Applications
WB, ELISA, IF, CDC

Conjugate
None

Product Property

Clonality
Monoclonal

Purification
Protein G purified

Purity
>95% determined as SDS-PAGE and SEC-HPLC

Aggregation
<5%

Buffer
PBS, pH 7.4

Preservative
No preservatives

Storage
Store at 4°C short term (1-2 weeks). Store at -20°C long term (12 months). Avoid repeated freeze/thaw cycles.

Target

Alternative Names
CD4 Molecule; T-Cell Surface Glycoprotein CD4; T-Cell Surface Antigen T4/Leu-3; CD4 Antigen (P55); CD4 Receptor; CD4 Antigen; CD4mut

Gene ID
920

UniProt ID
P01730

Long Name
CD4 Molecule

Sequence Similarities
The Ig-like V-type domain mediates the interaction with MHCII.

Post Translation Modifications
Palmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts. ( P01730-CD4_HUMAN )
Phosphorylated by PKC; phosphorylation at Ser-433 plays an important role for CD4 internalization. ( P01730-CD4_HUMAN )
Glycosylation at Asn296 and Asn325 ( NX_P01730 [NX_P01730-1] )
Ubiquitination at Lys453 ( NX_P01730 [NX_P01730-1] )

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Related Diseases

Primary Immunodeficiency

Downloadable Resources

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Datasheet

Datasheet - VS-0924-YC116.pdf

MSDS

MSDS - VS-0924-YC116.pdf

COA

Certificate of Analysis Lookup

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Protocol & Troubleshooting

Immunofluorescence (IF)

We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.

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