Mouse Anti-CD4 Recombinant Antibody Hexamer (VS-0924-YC116), CDC Enhanced (CAT#: VS-0924-YC116)
The product is a mouse anti-CD4 antibody hexamer that exhibits enhanced complement-dependent cytotoxicity (CDC) activity. This hexameric IgG1 targets human CD4 and includes mutations that promote hexamerization, facilitating optimal C1q binding and thereby enhancing CDC.
Specific Inquiry
Subcellular Location
RNA Expression
Figure 1 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/11/if_selected.jpg
(Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/11/if_selected.jpg
Figure 2 RNA cell line category: Group enriched (HEL, HL-60, NB-4, THP-1, U-937)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000010610-CD4
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000010610-CD4
Figure 2 RNA cell line category: Group enriched (HEL, HL-60, NB-4, THP-1, U-937)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000010610-CD4
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000010610-CD4
Specifications
- Immunogen
- Human CD4 peptide, RFLPADQMNVADPQPLASCS
- Host Species
- Mouse
- Type
- Antibody hexamer
- Specificity
- Human CD4
- Species Reactivity
- Human
- Molecule Class
- ~ 900 kDa
- Applications
- WB, ELISA, IF, CDC
- Conjugate
- None
Product Property
- Clonality
- Monoclonal
- Purification
- Protein G purified
- Purity
- >95% determined as SDS-PAGE and SEC-HPLC
- Aggregation
- <5%
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C short term (1-2 weeks). Store at -20°C long term (12 months). Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- CD4 Molecule; T-Cell Surface Glycoprotein CD4; T-Cell Surface Antigen T4/Leu-3; CD4 Antigen (P55); CD4 Receptor; CD4 Antigen; CD4mut
- Gene ID
- 920
- UniProt ID
- P01730
- Long Name
- CD4 Molecule
- Sequence Similarities
- The Ig-like V-type domain mediates the interaction with MHCII.
- Post Translation Modifications
- Palmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts. ( P01730-CD4_HUMAN )
Phosphorylated by PKC; phosphorylation at Ser-433 plays an important role for CD4 internalization. ( P01730-CD4_HUMAN )
Glycosylation at Asn296 and Asn325 ( NX_P01730 [NX_P01730-1] )
Ubiquitination at Lys453 ( NX_P01730 [NX_P01730-1] )
Related Resources
Primary Immunodeficiency
Downloads
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1067z | Mouse Anti-CD4 Recombinant Antibody (clone 34D6) | FC, FuncS, ICC, IF, IP, WB | Mouse IgG2b, κ |
| HPAB-2059LY | Mouse Anti-CD4 Recombinant Antibody (HPAB-2059LY) | FC | Mouse IgG |
| HPAB-0557-WJ | Human Anti-CD4 Recombinant Antibody (clone TRX1) | ELISA | Human IgG |
| HPAB-0558-WJ | Human Anti-CD4 Recombinant Antibody (clone 6G5) | ELISA | Human IgG |
| FAMAB-1058CQ | Human Anti-CD4 Recombinant Antibody (clone DB81) | Inhib, FC | Human IgG1 |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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