Anti-Human CD4 Recombinant Antibody (TAB-146) (CAT#: TAB-146)
Recombinant monoclonal antibody to CD4. It is a non-immunosuppressive monoclonal antibody that binds CD4, the primary receptor for HIV, and inhibits the viral entry process. It is being investigated as an HIV entry inhibitor with the ability to block both CCR5- and CXCR4-tropic viruses.
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WB
Figure 1 Anti-Human CD4 Therapeutic Antibody (TAB-146-L) in WB
Western blot analysis of TAB-146 was performed by loading Recombinant Human CD4 Protein (lane 1, 0.1 μg; lane 2, 0.3 μg; lane 3, 0.6 μg) onto a 12% Tris-HCl polyacrylamide gel. Proteins were transferred to a CN membrane and blocked with 5% skim milk for at least one hour. Membranes were probed with TAB-146-L and HRP Goat Anti-Human IgG as a secondary antibody. Chemiluminescent detection was performed.
ELISA
Figure 2 Anti-Human CD4 Therapeutic Antibody (TAB-146) in ELISA
ELISA analysis of TAB-146 was performed by coating with Recombinant Human CD4 Protein. Then blocked with BSA, and incubated with Anti-Human CD4 Antibody (TAB-146). The HRP-conjugated goat anti-human IgG as a secondary antibody. Detection was performed using TMB substrate and stopped with sulfuric acid. The absorbances were read on a spectrophotometer at 450 nm.
Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Mouse
- Derivation
- Humanized (from mouse)
- Type
- IgG4 - kappa
- Specificity
- Tested positive against native human antigen.
- Species Reactivity
- Human
- Applications
- FuncS, IF, Neut, ELISA, FC, IP, ICC
- Related Disease
- HIV-1 infection, AIDS
Product Property
- Purity
- >95.0% as determined by Analysis by RP-HPLC & analysis by SDS-PAGE.
- Storage
- 4°C. For long term storage, aliquot and store at -20°C. Repeated thawing and freezing must be avoided.
Applications
- Application Notes
- The CD4 antibody has been reported in applications of FuncS, IF, Neut, ELISA, FC, IP, ICC.
Target
- Alternative Names
- Ibalizumab;680188-33-4;TMB-355;TNX-355;Hu5A8;TNX-355;CD4;CD4 molecule;CD4 antigen (p55) , T cell surface glycoprotein CD4;T-cell surface glycoprotein CD4;CD4 receptor;CD4 antigen (p55);T-cell surface antigen T4/Leu-3;CD4mut;
- Gene ID
- 920
- UniProt ID
- P01730
Related Resources
Primary Immunodeficiency
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-039 | Anti-Human CD4 Recombinant Antibody (Zanolimumab) | Neut, ELISA, IF, IP, FuncS, FC, IHC | IgG1 - kappa |
Customer Reviews and Q&As
Customer Review
Ol***a
Suitable for ELISA
Suitable for ELISA
The antibody was tested in ELISA at concentration of 0.25-500 ng/mL.
28.Mar,25
Cite This Product
To accurately reference this product in your publication, please use the following citation information:
(Creative Biolabs Cat# TAB-146, RRID: AB_3111835)
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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