Afuco™ Anti-CD4 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-171)

Name: Afuco™ Anti-CD4 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-171)
SKU: AFC-TAB-171
Rating: 5 (1 reviews)

CAT#: AFC-TAB-171

This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to CD4. It is a monoclonal antibody for the treatment of severe chronic asthma. It suppresses the immune reaction by binding to white blood cells via the protein CD4. The drug is a chimeric antibody from Macaca irus and Homo sapiens.

Gene Expression

Subcellular Location Figure 1 IF staining of human cell line U-251 MG

Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/11/if_selected.jpg

RNA Expression Figure 2 RNA cell line category: Group enriched (HEL, HL-60, NB-4, THP-1, U-937)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000010610-CD4

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Specifications

Immunogen
Recombinant fragment (Human) corresponding to the external domain.

Host Species
Chimeric

Derivation
Chimeric (primate/human)

Type
ADCC enhanced antibody

Species Reactivity
Human

Applications
FuncS, IF, Neut, ELISA, FC, IP

Conjugate
Unconjugated

Generic Name
Keliximab

Related Disease
Rheumatoid arthritis (RA)

Product Property

Purity
>95% by SDS-PAGE

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Alternative Names
CD4; CD4 molecule; CD4 antigen (p55), T cell surface glycoprotein CD4; T-cell surface glycoprotein CD4; CD4 receptor; CD4 antigen (p55); T-cell surface antigen T4/Leu-3; CD4mut;

Gene ID
920

UniProt ID
P01730

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Biosimilar Overview

Please refer to Keliximab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Keliximab.

Related Diseases

Primary Immunodeficiency

Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - AFC-TAB-171.pdf

MSDS

MSDS - AFC-TAB-171.pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

Lot Number:

Protocol & Troubleshooting

Immunofluorescence (IF)

We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.

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