Recombinant Anti-Human CD4 Antibody (Fab glycosylation) (CAT#: Gly-025LC)
This product is a humanized monoclonal antibody with N-glycosylation site Asn-Ser-Thr in the light chain. The glyco-engineered antibody of higher neutralization activity specifically binds human CD4 and can be potentially used in the treatment of HIV.
Specific Inquiry
Subcellular Location
RNA Expression
Figure 1 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/11/if_selected.jpg
(Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/11/if_selected.jpg
Figure 2 RNA cell line category: Group enriched (HEL, HL-60, NB-4, THP-1, U-937)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000010610-CD4
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000010610-CD4
Figure 2 RNA cell line category: Group enriched (HEL, HL-60, NB-4, THP-1, U-937)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000010610-CD4
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000010610-CD4
Glyco-engineering
- Glycosylation site
- Asn-Ser-Thr in light chain
- Glycoform (ratio)
- Gal3NAc4F1 (NNH3NNF1) (~8%)
Gal3NAc5F1 (NNNH3NNF1) (~29%)
Gal4NAc5F1 (HNNNH3NNF1) (~24%)
- Glycosylation Type
- N-glycosylation
- Activity
- Higher neutralization activities
Specifications
- Target
- CD4 (Cluster of differentiation-4)
- Host Species
- Human
- Derivation
- Humanized
- Type
- Humanized antibody
- Specificity
- Human
- Clone
- LM52
- Expression Host
- 293A
- Applications
- ELISA
Target
- Alternative Names
- CD4; CD4 molecule; CD4mut; T-cell surface glycoprotein CD4; CD4 receptor; CD4 antigen (p55); T-cell surface antigen T4/Leu-3
- Related Disease
- HIV
- Gene ID
- 920
- UniProt ID
- B4DT49
Related Resources
Primary Immunodeficiency
Downloads
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-039 | Anti-Human CD4 Recombinant Antibody (Zanolimumab) | Neut, ELISA, IF, IP, FuncS, FC, IHC | IgG1 - kappa |
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For Research Use Only. Not For Clinical Use.
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