Can antibodies be employed on animals?

Some antibodies can be used for veterinary purposes, however formulations that have been particularly formulated and tested for animal usage are recommended.

What's the distinction between cloned and chimeric antibodies?

Humanized antibodies are essentially human, with only the antigen-binding sites coming from a non-human species, whereas chimeric antibodies contain higher amounts of both human and non-human components.

Do antibodies necessitate particular removal procedures?

To avoid environmental contamination and maintain safety, follow local legislation and recommendations when disposing of biological products.

Afuco™ Anti-CD4 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-039)

CAT#: AFC-TAB-039

This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to CD4. It is a human monoclonal antibody and an immunosuppressive drug. It is being developed for the treatment of rheumatoid arthritis, psoriasis, melanoma, cutaneous and peripheral T-cell lymphoma.

Gene Expression

Subcellular Location Figure 1 IF staining of human cell line U-251 MG

Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/11/if_selected.jpg

RNA Expression Figure 2 RNA cell line category: Group enriched (HEL, HL-60, NB-4, THP-1, U-937)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000010610-CD4

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Specifications

Immunogen
The details of the immunogen for this antibody are not available.

Host Species
Human

Derivation
Human

Type
ADCC enhanced antibody

Antibody Isotype
IgG1, κ

Species Reactivity
Human

Applications
Neut, ELISA, IF, IP, FuncS, FC

Conjugate
Unconjugated

Trade name
Humax-Cd4

Generic Name
Zanolimumab

Related Disease
Cutaneous T cell lymphoma (CTCL)

Product Property

Purity
>95% by SDS-PAGE

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Alternative Names
CD4; CD4 molecule; CD4 antigen (p55), T cell surface glycoprotein CD4; T-cell surface glycoprotein CD4; CD4 receptor; CD4 antigen (p55); T-cell surface antigen T4/Leu-3; CD4mut;

Gene ID
920

UniProt ID
P01730

REVIEWS AND Q&AS CITATIONS RESOURCES DOWNLOADS RELATED PRODUCTS

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Breast cancer biomarkers at key points during disease progression

Increased accuracy

This antibody product has helped us increase the accuracy of our detections and measurements, contributing to higher quality data.

Highly specific

The high specificity of this antibody product has reduced background noise in our assays, leading to clearer and more interpretable results.

Quality control

The stringent quality control measures for this product ensure its reliability, making it a dependable choice for our experiments.

Q&As

Can antibodies be employed on animals?

A: Some antibodies can be used for veterinary purposes, however formulations that have been particularly formulated and tested for animal usage are recommended.
What's the distinction between cloned and chimeric antibodies?

A: Humanized antibodies are essentially human, with only the antigen-binding sites coming from a non-human species, whereas chimeric antibodies contain higher amounts of both human and non-human components.
Do antibodies necessitate particular removal procedures?

A: To avoid environmental contamination and maintain safety, follow local legislation and recommendations when disposing of biological products.

View the frequently asked questions answered by Creative Biolabs Support.

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Biosimilar Overview

Please refer to Zanolimumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Zanolimumab.

Related Diseases

Primary Immunodeficiency

Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - AFC-TAB-039.pdf

MSDS

MSDS - AFC-TAB-039.pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

Lot Number:

Protocol & Troubleshooting

Immunofluorescence (IF)

We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.

See other products for "Zanolimumab"

Anti-Human CD4 Recombinant Antibody (Zanolimumab)
Recombinant monoclonal antibody to CD4. Zanolimumab (expected trade name HuMax-CD4) is a human monoclonal antibody and an immunosuppressive drug. It is being developed for the treatment of rheumatoid arthritis, psoriasis, melanoma, cutaneous and peripheral T-cell lymphoma.

DrugMonitor™ Anti-Zanolimumab Antibody (VS-1224-YC1341)
Zanolimumab is a fully human monoclonal antibody directed against CD4. The DrugMonitor™ Anti-Zanolimumab Antibody (VS-1224-YC1341) is an anti-drug antibody (ADA) against Zanolimumab. This drug-based antibody is raised in mice immunized with the Zanolimumab. The anti-Zanolimumab antibody may be used in ELISA, pharmacokinetics (PK), and pharmacodynamics (PD) analyses, or serves as a reference standard in ADA assays. It also is an excellent tool for therapeutic drug monitoring, allowing to evaluate the drug efficacy and determine the drug concentration of the Zanolimumab in samples.

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NEUT-355CQ	Mouse Anti-CD4 Recombinant Antibody (clone RPA-T4)	FC, CyTOF, Block, IHC	Mouse IgG1, κ

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NEUT-357CQ	Rat Anti-CD4 Recombinant Antibody (clone MAB0810)	Block, Depletion, Stim	Rat IgG2b

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NEUT-358CQ	Rat Anti-CD4 Recombinant Antibody (clone RM4-5)	FC, CyTOF, Depletion, Block, IHC	Rat IgG2a, κ

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MOR-0560	Hi-Affi™ Rabbit Anti-CD4 Recombinant Antibody (clone DS560AB)	IHC-P	Rabbit IgG

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AFC-TAB-164	Afuco™ Anti-CD4 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-164)	FuncS, IF, Neut, ELISA, FC	ADCC enhanced antibody

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VS-0225-XY48	CytoStream™ Mouse Anti-CD4 Recombinant Antibody (clone OKT4)	FC	Mouse IgG2b, kappa

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VS-0225-XY49	CytoStream™ Mouse Anti-CD4 Recombinant Antibody (clone OX-35)	FC	Mouse IgG2a, kappa

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VS-0225-XY50	CytoStream™ Rat Anti-CD4 Recombinant Antibody (clone RM4-4)	FC	Rat IgG2b, kappa

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VS-0225-XY51	CytoStream™ Mouse Anti-CD4 Recombinant Antibody (clone KEN-4)	FC, Block, IHC, IP	Mouse IgG2a, kappa

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VS-0325-FY64	Human Anti-CD4 (clone TRX1) scFv-Fc Chimera	ELISA	Human IgG1, scFv-Fc

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VS-0425-YC755	Recombinant Anti-CD4 Vesicular Antibody, EV Displayed (VS-0425-YC755)	ELISA, FC, Neut, Cell-uptake

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VS-0525-XY1178	Anti-CD4 Immunohistochemistry Kit	IHC

CAT	Product Name	Application	Type
VS-0525-XY1179	Anti-Mouse CD4 Immunohistochemistry Kit	IHC

CAT	Product Name	Application	Type
VS-0525-XY1180	Anti-Human CD4 Immunohistochemistry Kit	IHC

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