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Anti-CD4 immunotoxin M-T151 (IgG)-RTA (AGTO-G078R)

This immunotoxin was achieved by conjugating/fusing the Anti-CD4 monoclonal antibody to ricin toxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to tumor cells. Then the ricin A chain is incorporated into the cell by receptor-mediated endocytosis, blocking ribosomal protein synthesis and ultimately leading to cell death. It was designed for treatment of acute lymphoblastic leukemias (ALL).      
  • Datasheet

Specifications
Host
Mouse
Species Reactivity
Human
Clone
M-T151
Molecule Class
L kappa; IgG-RTA
Toxin Description
Ricin consist of two polypeptide chains, A and B, linked by means of disulfide bridge(s). Cytotoxicity is associated with the A chain and its 15 inhibition of protein synthesis in nucleated cells. The B chain is essentially a delivery vehicle for the A chain. The B chain recognizes polysaccharide units at the surface of cells and creates a high affinity interaction with such units. Once the B chain binds with polysaccharide units at 20" the celL surface, the A chain is incorporated into the cell, blocking ribosomal protein synthesis and ultimately leading tocell death. The use of ricin A chain is preferred in this invention.
Applications
This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
Related Disease
Acute lymphoblastic leukemias (ALL)
Target
Alternative Names
CD4; CD4 molecule; CD4mut; T-cell surface glycoprotein CD4; CD4 receptor; CD4 antigen (p55); T-cell surface antigen T4/Leu-3; Deglycosylated ricin A chain
Entrez Gene ID
920
UniProt ID
B4DT49

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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