Anti-CD4 immunotoxin M-T151 (IgG)-RTA (CAT#: AGTO-G078R)

This immunotoxin was achieved by conjugating/fusing the Anti-CD4 monoclonal antibody to ricin toxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to tumor cells. Then the ricin A chain is incorporated into the cell by receptor-mediated endocytosis, blocking ribosomal protein synthesis and ultimately leading to cell death. It was designed for treatment of acute lymphoblastic leukemias (ALL).


Specific Inquiry
  • Size:
  • Conjugation:
  • Endotoxin:
  • Purity:
  • Fc Engineering:
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
RNA Expression

Specifications

  • Host Species
  • Mouse
  • Species Reactivity
  • Human
  • Clone
  • M-T151
  • Molecule Class
  • L kappa; IgG-RTA
  • Toxin Description
  • Ricin consist of two polypeptide chains, A and B, linked by means of disulfide bridge(s). Cytotoxicity is associated with the A chain and its 15 inhibition of protein synthesis in nucleated cells. The B chain is essentially a delivery vehicle for the A chain. The B chain recognizes polysaccharide units at the surface of cells and creates a high affinity interaction with such units. Once the B chain binds with polysaccharide units at 20" the celL surface, the A chain is incorporated into the cell, blocking ribosomal protein synthesis and ultimately leading tocell death. The use of ricin A chain is preferred in this invention.
  • Applications
  • This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
  • Related Disease
  • Acute lymphoblastic leukemias (ALL)

Target

  • Alternative Names
  • CD4; CD4 molecule; CD4mut; T-cell surface glycoprotein CD4; CD4 receptor; CD4 antigen (p55); T-cell surface antigen T4/Leu-3; Deglycosylated ricin A chain; Ricin A chain; Ricin A; Ricin; RTA; RT; RA; dgRTA; dgRA; dgA

Related Resources

  • Related Diseases

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

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Human Antibody

CAT Product Name Application Type
TAB-039 Anti-Human CD4 Recombinant Antibody (Zanolimumab) Neut, ELISA, IF, IP, FuncS, FC, IHC IgG1 - kappa

Chimeric Antibody

CAT Product Name Application Type
TAB-171 Anti-Human CD4 Recombinant Antibody (Keliximab) FuncS, IF, Neut, ELISA, FC, IP, ICC IgG1 - lambda
TAB-732 Anti-CD4 Recombinant Antibody (Clenoliximab) IF, IP, Neut, FuncS, ELISA, FC, ICC IgG4 - lambda
TAB-162LC-S(P) Anti-Human CD4 Recombinant Antibody scFv Fragment ELISA Chimeric antibody (mouse/human)
TAB-167LC-F(E) Anti-Human CD4 Recombinant Antibody Fab Fragment (cM-T412) ELISA Chimeric antibody (mouse/human)
TAB-170LC-F(E) Human Anti-CD4 Recombinant Antibody; Fab Fragment (TAB-170LC-F(E)) ELISA, SPR Chimeric antibody (rat/human)

Immunotoxin

CAT Product Name Application Type
AGTO-G078E Anti-CD4 immunotoxin M-T151 (IgG)-PE Cytotoxicity assay, Function study

Fab Glycosylation

CAT Product Name Application Type
Gly-025LC Recombinant Anti-Human CD4 Antibody (Fab glycosylation) ELISA Humanized antibody

Blocking Antibody

CAT Product Name Application Type
NEUT-352CQ Mouse Anti-CD4 Recombinant Antibody (clone 13B8.2) Block, ELISA, FC, IHC-Fr, WB Mouse IgG1, κ
NEUT-355CQ Mouse Anti-CD4 Recombinant Antibody (clone RPA-T4) FC, CyTOF, Block, IHC Mouse IgG1, κ
NEUT-357CQ Rat Anti-CD4 Recombinant Antibody (clone MAB0810) Block, Depletion, Stim Rat IgG2b
NEUT-358CQ Rat Anti-CD4 Recombinant Antibody (clone RM4-5) FC, CyTOF, Depletion, Block, IHC Rat IgG2a, κ
NEUT-359CQ Rat Anti-CD4 Recombinant Antibody (clone YTS177) Block Rat IgG2a

Neutralizing Antibody

CAT Product Name Application Type
NEUT-353CQ Mouse Anti-CD4 Recombinant Antibody (clone CBL976) FC, Neut, IF, IHC Mouse IgG1, κ
NEUT-354CQ Recombinant Mouse Anti-CD4 Antibody (CT-4) Neut, FC, IHC, IHC-Fr, IHC-P, IP IgG1, κ
NEUT-356CQ Mouse Anti-CD4 Recombinant Antibody (clone 3-4F4) Neut, FC, IHC, IHC-Fr, IP, ICC Mouse IgG1, κ

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-0560 Hi-Affi™ Rabbit Anti-CD4 Recombinant Antibody (clone DS560AB) IHC-P Rabbit IgG

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-039 Afuco™ Anti-CD4 ADCC Recombinant Antibody (Zanolimumab), ADCC Enhanced Neut, ELISA, IF, IP, FuncS, FC ADCC enhanced antibody
AFC-TAB-164 Afuco™ Anti-CD4 ADCC Recombinant Antibody (Priliximab), ADCC Enhanced FuncS, IF, Neut, ELISA, FC ADCC enhanced antibody
AFC-TAB-260 Afuco™ Anti-CD4 ADCC Recombinant Antibody (Tregalizumab), ADCC Enhanced ELISA, FC, IP, FuncS, IF ADCC enhanced antibody
AFC-TAB-171 Afuco™ Anti-CD4 ADCC Recombinant Antibody (Keliximab), ADCC Enhanced FuncS, IF, Neut, ELISA, FC, IP ADCC enhanced antibody
AFC-TAB-107 Afuco™ Anti-CD4 ADCC Recombinant Antibody (Cedelizumab), ADCC Enhanced IF, IP, Neut, FuncS, ELISA, FC ADCC enhanced antibody

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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