Anti-CD8B (clone YTS156.7.7) Recombinant Antibody Coupled Liposome (VS-1024-FY170)
CAT#: VS-1024-FY170
These innovative liposomes are designed to incorporate anti-CD8B antibodies, allowing them to specifically latch onto CD8+ T cells within the tumor microenvironment. This targeting mechanism could significantly enhance the efficacy of immunotherapeutic strategies against melanoma by ensuring that therapeutic agents are precisely delivered to the appropriate immune cells. As a result, the focused delivery of these drugs has the potential to not only stimulate a stronger anti-tumor immune response but also improve the overall effectiveness of cancer treatments, ultimately leading to better patient outcomes.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line CACO-2
Immunofluorescent staining of human cell line CACO-2 shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/29164/1526_E8_1_selected.jpg
Normal Tissue
Figure 2 High expression in lymph node.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4353/165972_A_9_8_val_selected.jpg
Normal Tissue
Figure 3 Low expression in liver.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4353/165972_A_9_4_val_selected.jpg
Normal Tissue
Figure 4 Lymph node
Germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4353/165972_A_9_8.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enriched (RPMI-8226)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000172116-CD8B
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More Infomation
Specifications
- Potential Clinical Applications
- Melanoma
Product Composition
- Clone
- YTS156.7.7
- Antibody Type
- IgG1
- Antibody Host
- Rat
- Antibody Reactivity
- Mouse
- Antibody Description
- This recombinant rat monoclonal antibody has been adeptly tailored to interact with CD8B, a component that plays a vital role in the function of CD8 T cells. By binding to CD8B, this antibody contributes to the exploration of T cell receptor signaling and the overall dynamics of the adaptive immune system. Researchers can leverage its specificity to investigate immunological responses and to develop strategies that may improve immunotherapy efficacy.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- CD8B
- Introduction
- CD8B (CD8b Molecule) is a Protein Coding gene. Diseases associated with CD8B include Mucinous Stomach Adenocarcinoma. Among its related pathways are T-Cell Receptor and Co-stimulatory Signaling and Innate Immune System. Gene Ontology (GO) annotations related to this gene include coreceptor activity and MHC class I protein binding.
- Alternative Names
- CD8b Molecule; CD8 Antigen, Beta Polypeptide 1 (P37); CD8B1; T Lymphocyte Surface Glycoprotein Beta Chain; T-Cell Surface Glycoprotein CD8 Beta Chain; CD8b Antigen
- Full Name
- CD8b Molecule
- Gene ID
- 24931
- UniProt ID
- P05541
- Cellular Localization
- Cell membrane
- Post Translation Modifications
- Phosphorylated as a consequence of T-cell activation. ( P10966-CD8B_HUMAN )
Palmitoylated at the cytoplasmic tail and thereby targets the heterodimer CD8A/CD8B to lipid rafts unlike CD8A homodimers. ( P10966-CD8B_HUMAN )
Glycosylation at Asn102 ( NX_P10966 [NX_P10966-1] )
Modification sites at PhosphoSitePlus ( P10966 )
Glycosylation from GlyGen (P10966) 1 site
- Protein Refseq
- XP_011531466.1; XP_054200532.1; NP_001171571.1; NP_004922.1; NP_742099.1
- Function
- Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses.
In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex.
The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins.
Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs).
In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex.
A palmitoylation site in the cytoplasmic tail of CD8B chain contributes to partitioning of CD8 into the plasma membrane lipid rafts where signaling proteins are enriched.
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "Clone YTS156.7.7"
- CAT
- Product Name
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1604MZ | Recombinant Mouse Anti-Rat CD8B Antibody (clone 452) | FC, IHC-P, IP, WB | Mouse antibody |
| FAMAB-0012-CN | Mouse Anti-CD8B Recombinant Antibody (clone EP42) | FC | Mouse IgG |
| HPAB-S0182-YC | Rat Anti-Cd8b1 Recombinant Antibody (clone YTS156.7.7) | Neut | Rat IgG |
| FAMAB-1681CQ | Mouse Anti-CD8B Recombinant Antibody (clone YTS 156.7.7) | FC, IHC | Mouse IgG2a |
| VS-0224-XY29 | Monkey Anti-CD8B Recombinant Antibody (VS-0224-XY29) | Depletion, In vivo assay | Monkey IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-435CQ | Rat Anti-CD8B Recombinant Antibody (clone 53-5.8) | Depletion, Block, IF | Rat IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0591 | Hi-Affi™ Rabbit Anti-CD8B Recombinant Antibody (clone DS591AB) | ICC, IF, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0012-CN-S(P) | Mouse Anti-CD8B Recombinant Antibody (clone EP42); scFv Fragment | FC | Mouse scFv |
| HPAB-S0182-YC-S(P) | Rat Anti-Cd8b1 Recombinant Antibody (clone YTS156.7.7); scFv Fragment | Neut | Rat scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0012-CN-F(E) | Mouse Anti-CD8B Recombinant Antibody (clone EP42); Fab Fragment | FC | Mouse Fab |
| HPAB-S0182-YC-F(E) | Rat Anti-Cd8b1 Recombinant Antibody (clone YTS156.7.7); Fab Fragment | Neut | Rat Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY80 | CytoStream™ Mouse Anti-CD8B Recombinant Antibody (clone 2ST8.5H7) | FC | Mouse IgG2a, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY185 | Rat Anti-CD8B (clone YTS156.7.7) scFv-Fc Chimera | FC | Rat IgG2b, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC445 | Recombinant Anti-CD8B Vesicular Antibody, EV Displayed (VS-0425-YC445) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY1242 | Anti-CD8B Immunohistochemistry Kit | IHC | |
| VS-0525-XY1243 | Anti-Human CD8B Immunohistochemistry Kit | IHC | |
| VS-0525-XY1244 | Anti-Rat CD8B Immunohistochemistry Kit | IHC |
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