Anti-CD8B (clone YTS156.7.7) Recombinant Antibody Coupled Liposome (VS-1024-FY170) (CAT#: VS-1024-FY170)

• Potential Clinical Applications
• Melanoma

• Clone
• YTS156.7.7

• Antibody Type
• IgG1

• Antibody Host
• Rat

• Antibody Reactivity
• Mouse

• Antibody Description
• This recombinant rat monoclonal antibody has been adeptly tailored to interact with CD8B, a component that plays a vital role in the function of CD8 T cells. By binding to CD8B, this antibody contributes to the exploration of T cell receptor signaling and the overall dynamics of the adaptive immune system. Researchers can leverage its specificity to investigate immunological responses and to develop strategies that may improve immunotherapy efficacy.

• Storage
• See in the COA

• Storage Shelf Time
• See in the COA

• Target
• CD8B

• Introduction
• CD8B (CD8b Molecule) is a Protein Coding gene. Diseases associated with CD8B include Mucinous Stomach Adenocarcinoma. Among its related pathways are T-Cell Receptor and Co-stimulatory Signaling and Innate Immune System. Gene Ontology (GO) annotations related to this gene include coreceptor activity and MHC class I protein binding.

• Alternative Names
• CD8b Molecule; CD8 Antigen, Beta Polypeptide 1 (P37); CD8B1; T Lymphocyte Surface Glycoprotein Beta Chain; T-Cell Surface Glycoprotein CD8 Beta Chain; CD8b Antigen

• Full Name
• CD8b Molecule

• Gene ID
• 24931

• UniProt ID
• P05541

• Cellular Localization
• Cell membrane

• Post Translation Modifications
• Phosphorylated as a consequence of T-cell activation. ( P10966-CD8B_HUMAN )
  Palmitoylated at the cytoplasmic tail and thereby targets the heterodimer CD8A/CD8B to lipid rafts unlike CD8A homodimers. ( P10966-CD8B_HUMAN )
  Glycosylation at Asn102 ( NX_P10966 [NX_P10966-1] )
  Modification sites at PhosphoSitePlus ( P10966 )
  Glycosylation from GlyGen (P10966) 1 site

• Protein Refseq
• XP_011531466.1; XP_054200532.1; NP_001171571.1; NP_004922.1; NP_742099.1

• Function
• Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses.
  In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex.
  The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins.
  Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs).
  In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex.
  A palmitoylation site in the cytoplasmic tail of CD8B chain contributes to partitioning of CD8 into the plasma membrane lipid rafts where signaling proteins are enriched.

• HPAB-S0182-YC
• Rat Anti-Cd8b1 Recombinant Antibody (clone YTS156.7.7)

• HPAB-S0182-YC-F(E)
• Rat Anti-Cd8b1 Recombinant Antibody (clone YTS156.7.7); Fab Fragment

• HPAB-S0182-YC-S(P)
• Rat Anti-Cd8b1 Recombinant Antibody (clone YTS156.7.7); scFv Fragment

• VS-0325-FY185
• Rat Anti-CD8B (clone YTS156.7.7) scFv-Fc Chimera

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