Mouse Anti-HAVCR2 Recombinant Antibody (clone 5A7D12) (CAT#: VS7-0425-WR988)

• Immunogen
• Recombinant human TIM3 (AA: 224-301) fragment expressed in E. Coli.

• Host Species
• Mouse

• Type
• Mouse IgG1

• Specificity
• Human HAVCR2

• Species Reactivity
• Human

• Clone
• 5A7D12

• Molecule Class
• Immunoglobulin

• Applications
• WB, ELISA

• Conjugate
• Unconjugated

• Related Disease
• T-cell lymphoma, subcutaneous panniculitis-like (SPTCL)

• Clonality
• Monoclonal

• Purity
• >95% as determined by SDS-PAGE and SEC-HPLC analysis

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Buffer
• PBS

• Preservative
• 0.05% sodium azide

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Ice packs

• Application Notes
• Western Blot: 1:500 - 1:2000
  Enzyme-linked Immunosorbent Assay: 1:10000

• Alternative Names
• HAVCR2; HAVcr-2; TIMD-3; T-Cell Membrane Protein 3; TIMD3; Kidney Injury Molecule-3; Hepatitis A Virus Cellular Receptor 2; TIM3; Tim-3; T-Cell Immunoglobulin Mucin Family Member 3; T-Cell Immunoglobulin Mucin Receptor 3

• Gene ID
• 84868

• UniProt ID
• Q8TDQ0

• Long Name
• Hepatitis A virus cellular receptor 2

• Cellular Localization
• Cell junction; Cell membrane; Membrane

• Post Translation Modifications
• Disulfide bond; Glycoprotein; Phosphoprotein

• Protein Refseq
• NP_116171.3

• Function
• Cell surface receptor implicated in modulating innate and adaptive immune responses. Generally accepted to have an inhibiting function. Reports on stimulating functions suggest that the activity may be influenced by the cellular context and/or the respective ligand.; Regulates macrophage activation.; Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance.; In CD8+ cells attenuates TCR-induced signaling, specifically by blocking NF-kappaB and NFAT promoter activities resulting in the loss of IL-2 secretion. The function may implicate its association with LCK proposed to impair phosphorylation of TCR subunits, and/or LGALS9-dependent recruitment of PTPRC to the immunological synapse .;

Isotype Control

• MOB-066CQ
• Golden Syrian Hamster Anti-Podoplanin Antibody

Secondary Antibody

• 2RD-A1562-YJ
• Rabbit Anti-Mouse IgG1 Secondary antibody (Clone RM106)

Reconstitution Buffer

• MRO-0253YJ
• Reconstitution Buffer PBS

Recommended Dilution Buffer

• MRO-0253YJ
• Reconstitution Buffer PBS

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