This product is a recombinant human anti-HIV-1 monoclonal antibody. HT5 (205-43-1) specifically binds to gp120.
Figure 1 Inhibition of MAb b12 binding to monomeric gp120 byMAbs 205-42-15, 205-43-1, and 205-46-9.
The binding of MAbs b12(○), 205-42-15 (◆), 205-43-1 (■), and 205-46-9 (▲) to gp120 wasmeasured. An optical density at 490 nm (OD490nm) of 0.20 in thisassay represents an assay background (*).
Herrera, C., Spenlehauer, C., Fung, M. S., Burton, D. R., Beddows, S., & Moore, J. P. (2003). Nonneutralizing antibodies to the CD4-binding site on the gp120 subunit of human immunodeficiency virus type 1 do not interfere with the activity of a neutralizing antibody against the same site. Journal of virology, 77(2), 1084-1091.
Figure 2 Inhibition of MAb b12 binding to monomeric gp120 byMAbs 205-42-15, 205-43-1, and 205-46-9.
The inhibition of biotin-labeled b12 binding to gp120 by MAbs 205-43-1, 205-42-15, and 205-46-9 was measured. The effect of the absence of competitor in thisassay is also noted (×).
Herrera, C., Spenlehauer, C., Fung, M. S., Burton, D. R., Beddows, S., & Moore, J. P. (2003). Nonneutralizing antibodies to the CD4-binding site on the gp120 subunit of human immunodeficiency virus type 1 do not interfere with the activity of a neutralizing antibody against the same site. Journal of virology, 77(2), 1084-1091.
Figure 3 MAb 205-43-1 do not interfere with neutralization of HIV-1 JR-FL by MAb b12.
MAb 205-43-1 at the concentration indicated, with or without (◆) MAb b12 at 0.01 (○), 0.1 (△), or 1 (□) μg/ml, were mixed with HIV-1 JR-FL for 1 h prior to addition to PBMC. The outcome of infection was determined, and the percentage neutralization by the input antibodies was determined. The data points overlapping the y axis were derived in the absence of MAb (i.e., at 0 μg/ml).
Herrera, C., Spenlehauer, C., Fung, M. S., Burton, D. R., Beddows, S., & Moore, J. P. (2003). Nonneutralizing antibodies to the CD4-binding site on the gp120 subunit of human immunodeficiency virus type 1 do not interfere with the activity of a neutralizing antibody against the same site. Journal of virology, 77(2), 1084-1091.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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CAT | Product Name | Application | Type |
---|---|---|---|
PABL-135 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone PGT135) | ELISA, Neut | Human IgG |
PABL-142 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone 412d) | Neut, WB, ELISA, FuncS | Human IgG |
PABL-155 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone VRC03) | WB, ELISA, Neut, FuncS | Human IgG |
PABL-156 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone VRC-CH31) | WB, ELISA, Neut, FuncS | Human IgG |
PABL-160 | Mouse Anti-HIV-1 gp120 Recombinant Antibody (clone 59.1) | WB, ELISA, FuncS | Mouse IgG1, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
PSBL-135 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone PGT135); scFv Fragment | ELISA, Neut | Human scFv |
PSBL-142 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone 412d); scFv Fragment | WB, ELISA, FuncS | Human scFv |
PSBL-380 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone VRC06); scFv Fragment | Neut, FuncS | Human scFv |
PFBZ-209 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone 19.3H-L3); Fab Fragment | Neut | Human Fab |
PFBZ-210 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone 19.3H-L1); Fab Fragment | Neut | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-028LC-VHH | Anti-HIV-1 gp120 Recombinant Antibody (L91C2) | ELISA | Single domain antibody |
MRO-029LC-VHH | Anti-HIV-1 gp120 Recombinant Antibody (L91F10) | ELISA | Single domain antibody |
MRO-030LC-VHH | Anti-HIV-1 gp120 Recombinant Antibody (L91E1) | ELISA | Single domain antibody |
MRO-031LC-VHH | Anti-HIV-1 gp120 Recombinant Antibody (L91B5) | ELISA | Single domain antibody |
MRO-032LC-VHH | Anti-HIV-1 gp120 Recombinant Antibody (L91H9) | ELISA | Single domain antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-041LC | Anti-HIV-1 gp120 Recombinant Antibody (D59/A2) | ELISA | Mouse antibody |
MRO-042LC | Anti-HIV-1 gp120 Recombinant Antibody (F58/H3) | WB, ELISA | Mouse antibody |
MRO-043LC | Anti-HIV-1 gp120 Recombinant Antibody (P1/D12) | ELISA | Mouse antibody |
MRO-044LC | Anti-HIV-1 gp120 Recombinant Antibody (P4/D10) | ELISA | Mouse antibody |
MRO-045LC | Anti-HIV-1 gp120 Recombinant Antibody (A47/B1) | ELISA | Mouse antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-125LC | Anti-HIV-1 gp120 Recombinant Antibody (N6) | Neut, ELISA | Human antibody |
MRO-130LC | Human Anti-HIV-1 gp120 Recombinant Antibody (MRO-130LC) | ELISA, Neut, SPR | Human IgG |
MRO-136LC | Anti-HIV-1 gp120 Recombinant Antibody (Ab900973) | ELISA | Human antibody |
MRO-137LC | Anti-HIV-1 gp120 Recombinant Antibody (Ab900972) | ELISA | Human antibody |
MRO-138LC | Anti-HIV-1 gp120 Recombinant Antibody (Ab900990) | ELISA | Human antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-135LC | Anti-HIV-1 gp120 Recombinant Antibody (CAG1-51-4) | ELISA, WB, Neut | Chimeric antibody (mouse/human) |
MRO-135LC-S(P) | Anti-HIV-1 gp120 Recombinant Antibody scFv Fragment (CAG1-51-4) | ELISA, WB | Chimeric antibody (mouse/human) |
MRO-135LC-F(E) | Anti-HIV-1 gp120 Recombinant Antibody Fab Fragment (CAG1-51-4) | ELISA, WB | Chimeric antibody (mouse/human) |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-4220 | Rabbit Anti-HIV-1 gp120 Recombinant Antibody (clone SI299DS) | WB, ELISA | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
FAMAB-0177CQ-F(E) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone BAT123); Fab Fragment | Neut | Chimeric (mouse/human) Fab |
FAMAB-0178CQ-F(E) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone C beta 1); Fab Fragment | WB, Neut | Chimeric (mouse/human) Fab |
MRO-3081CQ-F(E) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone DH276); Fab Fragment | Neut | Human Fab |
MRO-3082CQ-F(E) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone DH374); Fab Fragment | Neut | Human Fab |
MRO-3083CQ-F(E) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone DH375); Fab Fragment | Neut | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
PABX-101-S(P) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone PG9); scFv Fragment | WB, ELISA, FuncS | Human scFv |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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