Rabbit Anti-PAX6 Recombinant Antibody (clone R03-8G4) (CAT#: VS3-FY1815)

• Immunogen
• Synthetic peptides of human PAX6

• Host Species
• Rabbit

• Type
• Rabbit IgG

• Specificity
• Human and Rat PAX6

• Species Reactivity
• Human, Rat

• Clone
• R03-8G4

• Applications
• Western Blot

• MW
• The calculated weight of the target protein is approximately 47 kDa, while the observed molecular weight stands at 47 kDa.

• Related Disease
• Coloboma Of Optic Nerve and Coloboma, Ocular, Autosomal Dominant

• Purification
• Affinity Purified

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Application Notes
• Western Blot: 1/500-1/1000

• Alternative Names
• Paired Box 6; Aniridia Type II Protein; Oculorhombin; AN2; Paired Box Gene 6 (Aniridia, Keratitis); Paired Box Homeotic Gene-6; Paired Box Protein Pax-6; Aniridia, Keratitis

• Gene ID
• 5080

• UniProt ID
• P26367

• Sequence Similarities
• Belongs to the paired homeobox family.

• Cellular Localization
• Nucleus

• Post Translation Modifications
• Ubiquitinated by TRIM11, leading to ubiquitination and proteasomal degradation.

• Protein Refseq
• NP_000271.1; NP_001121084.1; NP_001245393.1

• Function
• Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity).
  Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity).
  Acts as a transcriptional repressor of NFATC1-mediated gene expression (By similarity).

Isotype Control

• MOB-208CQ
• Rabbit IgG Isotype Control Antibody

Secondary Antibody

• 2ND-054CQ
• Goat Anti-Rabbit IgG Antibody, R-PE

• 2ND-059CQ
• Goat Anti-Rabbit IgG (H&L) Antibody

• 2ND-055CQ
• Chicken Anti-Rabbit IgG (H&L) Antibody