Anti-SELE (clone 5C7.29) Recombinant Antibody Coupled Liposome (VS-1024-FY201)
CAT#: VS-1024-FY201
E-selectin-specific monoclonal antibody-conjugated fluorescently labeled liposomes can specifically bind to stimulated HUVEC cells, allowing for the observation of this specific interaction through MRI and fluorescence microscopy. This newly developed system may serve as a useful diagnostic tool for studying pathological processes in vivo.
Gene Expression
Normal Tissue
Figure 1 Colon
Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2143/6009_A_7_3.jpg
Normal Tissue
Figure 2 Bone marrow
Hematopoietic cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2143/6009_B_6_4.jpg
RNA Expression
Figure 3 RNA cell line category: Cell line enriched (HUVEC TERT2)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000007908-SELE
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More Infomation
Specifications
- Potential Clinical Applications
- Potential diseases for studying endothelial cell inflammation and adhesion molecule expression, such as cardiovascular diseases, inflammatory diseases, or tumors, etc.
Product Composition
- Clone
- 5C7.29
- Antibody Type
- IgG2a
- Antibody Host
- Mouse
- Antibody Reactivity
- Human
- Antibody Description
- The 5C7.29 antibody is a monoclonal antibody that targets specific antigens on stimulated endothelial cells and recognizes antigens related to E-selectin. This antibody is used in research to identify and analyze the expression of E-selectin and its role in the adhesion of endothelial cells to leukocytes. The 5C7.29 antibody is crucial in the study of E-selectin, contributing to a deeper understanding of the interactions between endothelial cells and leukocytes, as well as the mechanisms involved in inflammatory responses.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- SELE
- Introduction
- The protein encoded by this gene is found in cytokine-stimulated endothelial cells and is thought to be responsible for the accumulation of blood leukocytes at sites of inflammation by mediating the adhesion of cells to the vascular lining. It exhibits structural features such as the presence of lectin- and EGF-like domains followed by short consensus repeat (SCR) domains that contain 6 conserved cysteine residues. These proteins are part of the selectin family of cell adhesion molecules. Adhesion molecules participate in the interaction between leukocytes and the endothelium and appear to be involved in the pathogenesis of atherosclerosis.
- Alternative Names
- Selectin E; Endothelial Leukocyte Adhesion Molecule 1; CD62 Antigen-Like Family Member E; Endothelial Adhesion Molecule 1; ELAM-1; LECAM2; ELAM1; Leukocyte Endothelial Cell Adhesion Molecule 2
- Full Name
- Selectin E
- Gene ID
- 6401
- UniProt ID
- P16581
- Sequence Similarities
- Belongs to the selectin/LECAM family.
- Cellular Localization
- Cell membrane
- Post Translation Modifications
- Glycosylation at Asn25, Asn145, Asn160, Asn179, Asn199, Asn203, Asn265, Asn312, Asn332, Asn503, and Asn527 ( NX_P16581 [NX_P16581-1] )
Modification sites at PhosphoSitePlus ( P16581 )
Glycosylation from GlyGen (P16581) 11 sites
- Protein Refseq
- NP_000441.2
- Function
- Cell-surface glycoprotein having a role in immunoadhesion.
Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with SELPLG/PSGL1.
May have a role in capillary morphogenesis.
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Downloadable Resources
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "Clone 5C7.29"
- CAT
- Product Name
See other products for "SELE"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| DrMAB-1058 | Recombinant Mouse Anti-Human SELE Antibody Fab Fragment | ELISA | Fab |
| PFBW-041 | Mouse Anti-SELE Recombinant Antibody (clone 7A9); Fab Fragment | Block | Mouse Fab |
| HPAB-0236-YC-F(E) | Mouse Anti-SELE Recombinant Antibody (clone 5C7.29); Fab Fragment | FC, Block | Mouse Fab |
| HPAB-1528WJ-F(E) | Mouse Anti-SELE Recombinant Antibody; Fab Fragment (clone CY1787) | ELISA, WB | Mouse Fab |
| HPAB-1529WJ-F(E) | Human Anti-SELE Recombinant Antibody; Fab Fragment (clone CY1788) | ELISA, WB | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABW-041 | Mouse Anti-SELE Recombinant Antibody (clone 7A9) | Block | Mouse IgG1, κ |
| HPAB-0006LY | Mouse Anti-SELE Recombinant Antibody (clone E1C/E1B) | WB, FC | Mouse IgG |
| MOB-0796-YJ | Mouse Anti-SELE Recombinant Antibody (CBE90D) | IHC-Fr, FuncS, IA, IP | Mouse IgG1 |
| ZG-1111F | Rat Anti-Sele Antibody (clone UZ5) | FC, ICC, IF, IHC-Fr, IP, WB | Rat IgG2b |
| ZG-1112F | Rat Anti-Sele Antibody (clone UZ6) | ELISA, FC, ICC, IF, IHC-Fr, IP, WB | Rat IgG2b |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBW-041 | Mouse Anti-SELE Recombinant Antibody (clone 7A9); scFv Fragment | Block | Mouse scFv |
| HPAB-0236-YC-S(P) | Mouse Anti-SELE Recombinant Antibody (clone 5C7.29); scFv Fragment | FC, Block | Mouse scFv |
| HPAB-0237-YC-S(P) | Human Anti-SELE Recombinant Antibody (clone hu5C7.29); scFv Fragment | FC, Block | Humanized scFv |
| HPAB-1528WJ-S(P) | Mouse Anti-SELE Recombinant Antibody; scFv Fragment (clone CY1787) | ELISA, WB | Mouse scFv |
| HPAB-1529WJ-S(P) | Human Anti-SELE Recombinant Antibody; scFv Fragment (clone CY1788) | ELISA, WB | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1928CQ | Recombinant Mouse Anti-Sele Antibody (RME-1/CD62E) | IF, IHC, ELISA, WB, IP, BL | IgG1, κ |
| NEUT-1929CQ | Recombinant Mouse Anti-SELE Antibody (NEUT-1929CQ) | BL, FC, IP, IHC, CyTOF, ICC | IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY232 | AbPlus™ Anti-SELE Magnetic Beads (BBIG-E1) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC600 | Recombinant Anti-SELE Vesicular Antibody, EV Displayed (VS-0425-YC600) | Block, ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY6429 | Anti-SELE Immunohistochemistry Kit | IHC | |
| VS-0525-XY6430 | Anti-Mouse SELE Immunohistochemistry Kit | IHC |
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