Anti-SELE (clone 5C7.29) Recombinant Antibody Coupled Liposome (VS-1024-FY201) (CAT#: VS-1024-FY201)

• Potential Clinical Applications
• Potential diseases for studying endothelial cell inflammation and adhesion molecule expression, such as cardiovascular diseases, inflammatory diseases, or tumors, etc.

• Clone
• 5C7.29

• Antibody Type
• IgG2a

• Antibody Host
• Mouse

• Antibody Reactivity
• Human

• Antibody Description
• The 5C7.29 antibody is a monoclonal antibody that targets specific antigens on stimulated endothelial cells and recognizes antigens related to E-selectin. This antibody is used in research to identify and analyze the expression of E-selectin and its role in the adhesion of endothelial cells to leukocytes. The 5C7.29 antibody is crucial in the study of E-selectin, contributing to a deeper understanding of the interactions between endothelial cells and leukocytes, as well as the mechanisms involved in inflammatory responses.

• Storage
• See in the COA

• Storage Shelf Time
• See in the COA

• Target
• SELE

• Introduction
• The protein encoded by this gene is found in cytokine-stimulated endothelial cells and is thought to be responsible for the accumulation of blood leukocytes at sites of inflammation by mediating the adhesion of cells to the vascular lining. It exhibits structural features such as the presence of lectin- and EGF-like domains followed by short consensus repeat (SCR) domains that contain 6 conserved cysteine residues. These proteins are part of the selectin family of cell adhesion molecules. Adhesion molecules participate in the interaction between leukocytes and the endothelium and appear to be involved in the pathogenesis of atherosclerosis.

• Alternative Names
• Selectin E; Endothelial Leukocyte Adhesion Molecule 1; CD62 Antigen-Like Family Member E; Endothelial Adhesion Molecule 1; ELAM-1; LECAM2; ELAM1; Leukocyte Endothelial Cell Adhesion Molecule 2

• Full Name
• Selectin E

• Gene ID
• 6401

• UniProt ID
• P16581

• Sequence Similarities
• Belongs to the selectin/LECAM family.

• Cellular Localization
• Cell membrane

• Post Translation Modifications
• Glycosylation at Asn25, Asn145, Asn160, Asn179, Asn199, Asn203, Asn265, Asn312, Asn332, Asn503, and Asn527 ( NX_P16581 [NX_P16581-1] )
  Modification sites at PhosphoSitePlus ( P16581 )
  Glycosylation from GlyGen (P16581) 11 sites

• Protein Refseq
• NP_000441.2

• Function
• Cell-surface glycoprotein having a role in immunoadhesion.
  Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with SELPLG/PSGL1.
  May have a role in capillary morphogenesis.

• HPAB-0236-YC
• Mouse Anti-SELE Recombinant Antibody (clone 5C7.29)

• HPAB-0236-YC-S(P)
• Mouse Anti-SELE Recombinant Antibody (clone 5C7.29); scFv Fragment

• HPAB-0236-YC-F(E)
• Mouse Anti-SELE Recombinant Antibody (clone 5C7.29); Fab Fragment

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