Mouse Anti-TH Recombinant Antibody (clone 4B1)
CAT#: VS3-WK1590
This antibody is a mouse recombinant antibody against human TH, which is the rate-limiting enzyme in the synthesis of catecholamines, hence plays a key role in the physiology of adrenergic neurons. The clone 4B1 can be used in WB analysis at a dilution of 1/1000-1/2000 and IHC analysis at a dilution of 1/50-1/200.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line PC-3
Immunofluorescent staining of human cell line PC-3 shows localization to cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14010/1905_B8_3_selected.jpg
Normal Tissue
Figure 2 High expression in adrenal gland
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/61003/159875_B_6_5_val_selected.jpg
Normal Tissue
Figure 3 Low expression in pancreas
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/61003/160099_A_3_3_val_selected.jpg
RNA Expression
Figure 4 RNA cell line category: Group enriched (PC-3, SK-BR-3)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000180176-TH
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Specifications
- Immunogen
- Synthesized peptide derived from human Tyrosine Hydrolase
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Human TH
- Species Reactivity
- Human, Mouse, Rat
- Clone
- 4B1
- Applications
- IHC-P, WB
- Conjugate
- Unconjugated
Product Property
- Clonality
- Monoclonal
- Purification
- Protein G affinity purified
- Purity
- >95% as determined by SDS-PAGE
- Aggregation
- < 5%
- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- PBS, 0.5% BSA, 50% Glycerol
- Preservative
- 0.02% Sodium Azide
- Storage
- Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- IHC-P: 1/50-1/200
WB: 1/1000-1/2000
Target
- Alternative Names
- Tyrosine Hydroxylase; Tyrosine 3-Monooxygenase; Tyrosine 3-Hydroxylase; EC 1.14.16.2; TYH; Dystonia 14; EC 1.14.16; DYT14; DYT5b
- Gene ID
- 7054
- UniProt ID
- P07101
- Long Name
- Tyrosine Hydroxylase
- Sequence Similarities
- Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.
- Cellular Localization
- Cell projection, Cytoplasm, Cytoplasmic vesicle, Nucleus, Synapse
- Post Translation Modifications
- Phosphorylated on Ser-19, Ser-62 and Ser-71 by several protein kinases with different site specificities. Phosphorylation at Ser-62 and Ser-71 leads to an increase of TH activity
- Protein Refseq
- NP_000351.2
- Function
- Catalyzes the conversion of L-tyrosine to L-dihydroxyphenylalanine (L-Dopa), the rate-limiting step in the biosynthesis of cathecolamines, dopamine, noradrenaline, and adrenaline. Uses tetrahydrobiopterin and molecular oxygen to convert tyrosine to L-Dopa.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
Isotype Control
- CAT
- Product Name
See other products for "TH"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0734MZ | Chicken Anti-TH Polyclonal IgY | ICC, IF, IHC, WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3558 | Rabbit Anti-TH Recombinant Antibody (clone DS3558AB) | WB, FC | Rabbit IgG |
| MOR-4763 | Rabbit Anti-TH Recombinant Antibody (clone TH277DS) | WB, IF, ICC, FC | Rabbit IgG |
| MOR-0099-FY | Rabbit Anti-TH Recombinant Antibody (clone AFY0070) | ICC, IF, IHC-P, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-1545-CN | Rabbit Anti-TH Recombinant Antibody (clone CBACN-567) | WB, IF, IHC, FC | Rabbit IgG |
| MRO-1546-CN | Rabbit Anti-TH Recombinant Antibody (clone CBACN-568) | WB, IF, IHC, FC | Rabbit IgG |
| MRO-2249-CN | Rabbit Anti-TH Polyclonal Antibody (MRO-2249-CN) | WB, IF, IHC, FC | Rabbit IgG |
| VS3-CJ456 | Rabbit Anti-TH Recombinant Antibody (VS3-CJ456) | WB, ICC, IHC, FC | Rabbit IgG |
| VS7-0425-WR979 | Mouse Anti-TH Recombinant Antibody (clone 1B8D2) | WB, IHC, ICC, FC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-CN1269 | PE-H-2Kk/Human TH (FETFEAKI) MHC Tetramer | FCM, IHC | |
| MHC-CN1270 | APC-H-2Kk/Human TH (FETFEAKI) MHC Tetramer | FCM, IHC | |
| MHC-CN1271 | FITC-H-2Kk/Human TH (FETFEAKI) MHC Tetramer | FCM, IHC | |
| MHC-CN1272 | H-2Kk/Human TH (FETFEAKI) MHC Tetramer | FCM, IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC381 | AbPlus™ Anti-TH Magnetic Beads (VS-0724-YC381) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY2280 | Anti-TH Immunohistochemistry Kit | IHC | |
| VS-0525-XY7225 | Anti-Mouse TH Immunohistochemistry Kit | IHC | |
| VS-0525-XY7224 | Anti-Human TH Immunohistochemistry Kit | IHC | |
| VS-0525-XY7226 | Anti-Rat TH Immunohistochemistry Kit | IHC |
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