Mouse Anti-TH Recombinant Antibody (clone 4B1) (CAT#: VS3-WK1590)
This antibody is a mouse recombinant antibody against human TH, which is the rate-limiting enzyme in the synthesis of catecholamines, hence plays a key role in the physiology of adrenergic neurons. The clone 4B1 can be used in WB analysis at a dilution of 1/1000-1/2000 and IHC analysis at a dilution of 1/50-1/200.
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Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line PC-3
(Immunofluorescent staining of human cell line PC-3 shows localization to cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14010/1905_B8_3_selected.jpg
(Immunofluorescent staining of human cell line PC-3 shows localization to cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14010/1905_B8_3_selected.jpg
Figure 2 High expression in adrenal gland
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/61003/159875_B_6_5_val_selected.jpg
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/61003/159875_B_6_5_val_selected.jpg
Figure 3 Low expression in pancreas
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/61003/160099_A_3_3_val_selected.jpg
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/61003/160099_A_3_3_val_selected.jpg
Figure 4 RNA cell line category: Group enriched (PC-3, SK-BR-3)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000180176-TH
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000180176-TH
Specifications
- Immunogen
- Synthesized peptide derived from human Tyrosine Hydrolase
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Human TH
- Species Reactivity
- Human, Mouse, Rat
- Clone
- 4B1
- Applications
- IHC-P, WB
- Conjugate
- Unconjugated
Product Property
- Clonality
- Monoclonal
- Purification
- Protein G affinity purified
- Purity
- >95% as determined by SDS-PAGE
- Aggregation
- < 5%
- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- PBS, 0.5% BSA, 50% Glycerol
- Preservative
- 0.02% Sodium Azide
- Storage
- Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- IHC-P: 1/50-1/200
WB: 1/1000-1/2000
Target
- Alternative Names
- Tyrosine Hydroxylase; Tyrosine 3-Monooxygenase; Tyrosine 3-Hydroxylase; EC 1.14.16.2; TYH; Dystonia 14; EC 1.14.16; DYT14; DYT5b
- Gene ID
- 7054
- UniProt ID
- P07101
- Long Name
- Tyrosine Hydroxylase
- Sequence Similarities
- Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.
- Cellular Localization
- Cell projection, Cytoplasm, Cytoplasmic vesicle, Nucleus, Synapse
- Post Translation Modifications
- Phosphorylated on Ser-19, Ser-62 and Ser-71 by several protein kinases with different site specificities. Phosphorylation at Ser-62 and Ser-71 leads to an increase of TH activity
- Protein Refseq
- NP_000351.2
- Function
- Catalyzes the conversion of L-tyrosine to L-dihydroxyphenylalanine (L-Dopa), the rate-limiting step in the biosynthesis of cathecolamines, dopamine, noradrenaline, and adrenaline. Uses tetrahydrobiopterin and molecular oxygen to convert tyrosine to L-Dopa.
Recommended Products
Secondary Antibody
Isotype Control
Related Resources
Amphetamine Addiction
Alcoholism
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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IHC Kit and Antibody Products: Precision Tools for Immunohistochemistry
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2042z | Mouse Anti-TH Recombinant Antibody (clone 26H11) | WB, ICC, IF | Mouse IgG2a |
| MRO-1545-CN | Rabbit Anti-TH Recombinant Antibody (clone CBACN-567) | WB, IF, IHC, FC | Rabbit IgG |
| MRO-2249-CN | Rabbit Anti-TH Polyclonal Antibody (MRO-2249-CN) | WB, IF, IHC, FC | Rabbit IgG |
| VS3-CJ456 | Rabbit Anti-TH Recombinant Antibody (VS3-CJ456) | WB, ICC, IHC, FC | Rabbit IgG |
| VS3-FY1925 | Rabbit Anti-TH Recombinant Antibody (clone R01-3E4) | WB, IHC-Fr, IHC-P, IF | Rabbit IgG |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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