IgA-IgG Hybrid Molecule Development Services
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Combining the Best of Two Immunoglobulin Worlds
At Creative Biolabs, we provide industry-leading IgA-IgG Hybrid Molecule Development Services, offering end-to-end design, production, and characterization solutions tailored to therapeutic development. Our platform enables the construction of chimeric antibodies or next-generation seed body scaffolds with dual functional benefits—enhancing drug stability, broadening tissue distribution, and enabling multifunctional immune engagement.
Scientific Rationale Behind IgA-IgG Hybrids
- IgA antibodies are specialized for mucosal immunity, with strong engagement of FcαRI and effective recruitment of neutrophils and macrophages. However, their serum half-life is limited due to poor FcRn binding and susceptibility to clearance receptors.
- IgG antibodies, particularly IgG1, exhibit long serum half-life due to pH-dependent FcRn recycling and widespread clinical validation, but lack robust mucosal transcytosis and Fcα-mediated responses.
By engineering hybrid constructs that integrate key domains from both isotypes, we aim to create therapeutics that retain IgA's mucosal or effector features while acquiring the favorable pharmacokinetics of IgG.
What We Offer
IgA-IgG Chimeric Antibody Production Service
This service focuses on the rational design and recombinant production of chimeric antibodies combining domains of IgA and IgG. Examples include fusing the variable domains of IgA onto an IgG Fc scaffold, or grafting IgG FcRn binding motifs into the IgA CH2/CH3 region.
Service Features:
- Domain Grafting & Format Design: Custom chimeras with IgA Fab + IgG Fc, or dual Fc constructs (e.g., IgA/IgG bispecifics).
- Isotype Switching & Linker Optimization: Spacer regions optimized for structural flexibility and receptor engagement.
- Recombinant Expression: Production in mammalian cell lines (CHO or HEK293) with high yield and glycosylation control.
- Analytical Characterization: SDS-PAGE, SEC-HPLC, FcRn binding (SPR/ELISA), FcαRI/FcγRI engagement profiling.
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IgA-based Seed Body Production Service
"Seed bodies" refer to antibody frameworks engineered for future modular development. In this service, we create IgA-based modular antibody scaffolds that retain FcαRI interaction and mucosal transcytosis but incorporate features such as engineered Fc regions, FcRn-binding domains, or IgG-compatible Fc sites for flexible downstream development.
Service Features:
- Scaffold Engineering: Production of optimized IgA1/IgA2 constant region frameworks with optional IgG-derived functional sites.
- Platform Molecule Production: Generation of seed bodies for bispecific, trispecific, or fusion-ready IgA-based biologics.
- Mucosal-Compatibility Testing: pIgR-mediated transport assay and polymeric IgA behavior evaluation.
- Functionality Screening: Cross-isotype Fc receptor binding, effector function assays (e.g., ADCC, phagocytosis).
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Applications of IgA-IgG Hybrids
- Mucosal-targeted immunotherapies with improved serum bioavailability
- Oncology and infectious disease biologics that leverage neutrophil-driven cytotoxicity and systemic persistence
- Multifunctional antibody platforms with extended PK and multi-receptor recruitment (FcαRI, FcγRI/III)
- IgA-like checkpoint blockade or immune agonist delivery
Service Workflow
Partner with Creative Biolabs
With deep technical expertise in antibody isotype engineering, glycoscience, and immunobiology, Creative Biolabs is uniquely positioned to support the development of IgA-IgG hybrid antibodies from concept to validation. Whether you require a proof-of-concept chimeric antibody or a production-ready IgA-based seed body, our scientists deliver science-driven solutions and reliable execution.
Contact us today to explore how our IgA-IgG Hybrid Molecule Development Services can bring next-generation antibody therapeutics closer to reality.
For research use only. Not intended for any clinical use.
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