Mouse Anti-LPS (clone WN1 222-5) scFv-Fc Chimera (CAT#: VS-0425-FY23)
The anti-LPS scFv-Fc antibody is a specific monoclonal antibody designed to bind to lipopolysaccharide (LPS), a crucial component of the outer membrane of Gram-negative bacteria such as Escherichia coli. This antibody is capable of recognizing and binding to the LPS structure, making it a valuable tool for research and diagnostic applications. The binding specificity of the anti-LPS scFv-Fc antibody allows it to be used in various assays to detect and quantify LPS, which is often associated with bacterial infections and inflammation.
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Custom Production
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
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Specifications
- Immunogen
- The immunization procedure involved intravenous injections of heat-killed bacteria, using a combination of different E. coli and salmonella minnesota strains.
- Host Species
- Mouse
- Type
- Mouse IgG2a, scFv-Fc
- Specificity
- E. coli LPS
- Species Reactivity
- E. coli
- Clone
- WN1 222-5
- Applications
- Western Blot, ELISA
- Related Disease
- E. coli
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- LPS; Lipopolysaccharides
- Long Name
- Francisella tularensis LPS
- Function
- The term "LPS" typically refers to lipopolysaccharide, a large molecule found in the outer membrane of Gram-negative bacteria. It is not a gene itself, but rather a complex molecule synthesized through the action of multiple bacterial genes.
The primary function of LPS is to contribute to the structural integrity of the bacterial outer membrane and protect the bacteria from host defenses, such as bile salts and hydrophobic antibiotics. However, LPS is also a potent endotoxin and a key activator of the mammalian innate immune system.
When recognized by host immune cells through receptors like Toll-like receptor 4 (TLR4), LPS triggers a cascade of signaling events. This leads to the production of pro-inflammatory cytokines, chemokines, and other mediators that initiate an immune response to combat bacterial infection. While crucial for host defense, excessive LPS stimulation can lead to detrimental effects like septic shock.
Related Resources
Rheumatoid Arthritis
Graft-versus-Host Disease
TLR Signaling Pathway
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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IgG Antibody Products
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IgM Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-630 | Recombinant Anti-LPS Antibody | ELISA, WB, FC, FuncS | IgG |
| PABL-078 | Recombinant Mouse Anti-E. coli LPS Antibody (WN1 222-5) | WB, ELISA, FuncS | IgG |
| PABL-477 | Recombinant Mouse Anti-Ft LPS Antibody (PABL-477) | WB, ELISA, Inhib | IgG |
| PABC-178 | Recombinant Mouse Anti-F. tularensis LPS Antibody (Ab52) | WB | IgG |
| FAMAB-0104-CN | Recombinant Human Anti-LPS Antibody (S20) | ELISA, FC, BL | Human IgG2 |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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