Mouse Anti-LPS (clone WN1 222-5) scFv-Fc Chimera
CAT#: VS-0425-FY23
The anti-LPS scFv-Fc antibody is a specific monoclonal antibody designed to bind to lipopolysaccharide (LPS), a crucial component of the outer membrane of Gram-negative bacteria such as Escherichia coli. This antibody is capable of recognizing and binding to the LPS structure, making it a valuable tool for research and diagnostic applications. The binding specificity of the anti-LPS scFv-Fc antibody allows it to be used in various assays to detect and quantify LPS, which is often associated with bacterial infections and inflammation.
Specifications
- Immunogen
- The immunization procedure involved intravenous injections of heat-killed bacteria, using a combination of different E. coli and salmonella minnesota strains.
- Host Species
- Mouse
- Type
- Mouse IgG2a, scFv-Fc
- Specificity
- E. coli LPS
- Species Reactivity
- E. coli
- Clone
- WN1 222-5
- Applications
- Western Blot, ELISA
- Related Disease
- E. coli
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- LPS; Lipopolysaccharides
- Long Name
- Francisella tularensis LPS
- Function
- The term "LPS" typically refers to lipopolysaccharide, a large molecule found in the outer membrane of Gram-negative bacteria. It is not a gene itself, but rather a complex molecule synthesized through the action of multiple bacterial genes.
The primary function of LPS is to contribute to the structural integrity of the bacterial outer membrane and protect the bacteria from host defenses, such as bile salts and hydrophobic antibiotics. However, LPS is also a potent endotoxin and a key activator of the mammalian innate immune system.
When recognized by host immune cells through receptors like Toll-like receptor 4 (TLR4), LPS triggers a cascade of signaling events. This leads to the production of pro-inflammatory cytokines, chemokines, and other mediators that initiate an immune response to combat bacterial infection. While crucial for host defense, excessive LPS stimulation can lead to detrimental effects like septic shock.
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Related Diseases
Rheumatoid Arthritis
Graft-versus-Host Disease
Related Signaling Pathways
TLR Signaling Pathway
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-630 | Recombinant Anti-LPS Antibody | ELISA, WB, FC, FuncS | IgG |
| PABL-477 | Recombinant Mouse Anti-Ft LPS Antibody (PABL-477) | WB, ELISA, Inhib | IgG |
| HPAB-0422-WJ | Recombinant Mouse Anti-LPS Antibody (2459) | ELISA, FC | Mouse IgG |
| HPAB-0423-WJ | Recombinant Mouse Anti-LPS Antibody (2409) | ELISA, FC | Mouse IgG |
| HPAB-0424-WJ | Recombinant Mouse Anti-LPS Antibody (2453) | ELISA, FC | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NABL-060 | Recombinant Anti-V. cholerae O1 LPS VHH Single Domain Antibody | WB, ELISA, IP, FuncS | Llama VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHH-630-S(P) | Recombinant Human Anti-LPS Antibody scFv Fragment | IF, Neut, FuncS | scFv |
| PSBL-265 | Recombinant Mouse Anti-LPS Antibody scFv Fragment (S25-2) | WB, IHC, FuncS | scFv |
| PSBW-013 | Mouse Anti-LPS Recombinant Antibody (clone S45-18); scFv Fragment | WB, ELISA | Mouse scFv |
| PSBW-168 | Mouse Anti-LPS Recombinant Antibody (clone F22-4); scFv Fragment | ELISA | Mouse scFv |
| HPAB-J0169-YC-S(P) | Recombinant Human Anti-LPS Antibody scFv Fragment (216-01) | ELISA, FuncS | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-265 | Recombinant Mouse Anti-LPS Antibody Fab Fragment (S25-2) | WB, IHC, FuncS | Fab |
| PFBW-013 | Mouse Anti-LPS Recombinant Antibody (clone S45-18); Fab Fragment | WB, ELISA | Mouse Fab |
| PFBW-168 | Mouse Anti-LPS Recombinant Antibody (clone F22-4); Fab Fragment | ELISA | Mouse Fab |
| PSBC-178 | Recombinant Mouse Anti-F. tularensis LPS Antibody scFv Fragment (Ab52) | WB | scFv |
| HPAB-J0169-YC-F(E) | Recombinant Human Anti-LPS Antibody Fab Fragment (216-01) | ELISA, FuncS | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-J0169-YC | Recombinant Human Anti-LPS Antibody (216-01) | ELISA, FuncS | Human IgM, κ |
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