Mouse Anti-TIE1 scFv-Fc Chimera (VS-0325-FY15) (CAT#: VS-0325-FY15)
The anti-TIE1 scFv-Fc antibody targets TIE1, a receptor involved in maintaining vascular integrity and endothelial cell function. It can modulate TIE1 signaling, potentially affecting vascular stability and permeability. The scFv-Fc format provides high specificity and prolonged half-life, enhancing its utility in research and therapeutic applications.
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Custom Production
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
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RNA Expression
Figure 1 RNA cell line category: Group enriched (EFO-21, HUVEC TERT2, TIME)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000066056-TIE1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000066056-TIE1
Specifications
- Immunogen
- The purified human Tie-2-Fc protein.
- Host Species
- Mouse
- Type
- Mouse IgG1, scFv-Fc
- Specificity
- Human TIE1
- Species Reactivity
- Human
- Applications
- ELISA, Flow Cytometry
- Related Disease
- Vascular-related disease
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains 1; Tyrosine Kinase With Immunoglobulin And Epidermal Growth Factor Homology Domains 1; EC 2.7.10.1; TIE; Tyrosine Kinase With Immunoglobulin-Like And EGF-Like Domains 1; Tyrosine-Protein Kinase Receptor Tie-1; EC 2.7.10; JTK14
- Gene ID
- 7075
- UniProt ID
- P35590
- Long Name
- Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains 1
- Sequence Similarities
- Belongs to the protein kinase superfamily.
- Cellular Localization
- Cell membrane
- Post Translation Modifications
- Phosphorylated on tyrosine residues in response to ANGPT1, most likely by TEK/TIE2.
Glycosylation at Asn83, Asn161, Asn503, Asn596, and Asn709
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 6 sites, 3 N-linked glycans (1 site), 1 O-linked glycan (1 site)
- Protein Refseq
- XP_005271220.1; XP_016857696.1; XP_047285299.1; XP_047285310.1; XP_054194526.1
- Function
- Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis.
Recommended Products
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Human Antibody Products
IgG Antibody Products
Fab Antibody Products
ScFv Antibody Products
Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-608CL | Human Anti-TIE1 Recombinant Antibody (TAB-608CL) | ELISA | Human IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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