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ACTA1
Anti-ACTA1 Recombinant Antibody Products
- Rabbit Anti-ACTA1 Recombinant Antibody (clone CBACN-009) (MRO-0024-CN)
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- Species Reactivity: Human, Mouse, Rat, Zebrafish
- Type: Rabbit IgG
- Application: WB, IF, IHC, IP
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- Rabbit Anti-ACTA1 Recombinant Antibody (clone JF47-01) (MRO-0025-CN)
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- Species Reactivity: Human, Mouse, Rat, Zebrafish
- Type: Rabbit IgG
- Application: WB, IP
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- Species Reactivity: Human, Amphibia, Bony fish, Cow, Guinea Pig, Reptiles, Rabbit, Rat, Sheep
- Type: Mouse IgM
- Application: IHC-Fr, IHC-P
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- Species Reactivity: Human, Rat, Hamster
- Type: Rabbit IgG
- Application: WB, IHC-F, IHC-P, ICC, IF, IP
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- Derivation: Mouse
- Species Reactivity: Human, Mouse, Rat
- Type: Mouse IgG
- Application: ELISA, WB, IP
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- Mouse Anti-ACTA1 Recombinant Antibody (clone 4G10) (VS3-WK1580)
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- Species Reactivity: Human, Rat, Mouse
- Type: Mouse IgG
- Application: IHC-P, IF
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- Rabbit Anti-ACTA1 Recombinant Antibody (VS3-FY2619) (VS3-FY2619)
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- Species Reactivity: Human, Rat, Hamster
- Type: Rabbit IgG
- Application: WB, IHC, ICC, IP
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- Rabbit Anti-ACTA1 Recombinant Antibody (VS3-CJ1108) (VS3-CJ1108)
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- Species Reactivity: Human, Mouse, Rat, Zebrafish
- Type: Rabbit IgG
- Application: WB, ICC, IF, IHC, IP
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- Mouse Anti-ACTA1 Recombinant Antibody (clone 1E12) (VS3-WK1267)
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- Derivation: Mouse
- Species Reactivity: Human, Rat, Mouse
- Type: Mouse IgG1
- Application: WB
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- Mouse Anti-ACTA1 Recombinant Antibody (clone PT1715) (VS3-WK1370)
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: IHC-P
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- Species Reactivity: Caprine, Human, Rabbit, Rat, Pig
- Type: Mouse IgG1
- Application: ELISA, IHC-Fr, IHC-P, WB
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- Derivation: Mouse
- Species Reactivity: Human, Rat, Mouse
- Type: Mouse IgG1
- Application: WB, IHC
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- Mouse Anti-ACTA1 Recombinant Antibody (VS3-CJ1107) (VS3-CJ1107)
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- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: WB, IHC, FC
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For Research Use Only. Not For Clinical Use.
The product encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Mutations in this gene cause nemaline myopathy type 3, congenital myopathy with excess of thin myofilaments, congenital myopathy with cores, and congenital myopathy with fiber-type disproportion, diseases that lead to muscle fiber defects.
Protein class
Disease related genes, Human disease related genes, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Group enriched (Cardiomyocytes, Skeletal myocytes)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enriched (BEWO)
Interaction
Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others. Interacts with alpha-actinin (By similarity). Identified in a complex composed of ACTA1, COBL, GSN AND TMSB4X (By similarity). Interacts with TTID (PubMed:10958653). Interacts (via its C-terminus) with USP25; the interaction occurs for all USP25 isoforms but is strongest for isoform USP25m in muscle differentiating cells (PubMed:16501887).
Molecular function
Muscle protein
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