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AKT1S1
Anti-AKT1S1 Recombinant Antibody Products
- Mouse Anti-AKT1S1 Recombinant Antibody (clone 84Q32) (MOB-1680CT)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: IP, WB
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- Mouse Anti-AKT1S1 Recombinant Antibody (VS3-WK1098) (VS3-WK1098)
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- Derivation: Mouse
- Species Reactivity: Human, Mouse
- Type: Mouse IgG1, κ
- Application: WB
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For Research Use Only. Not For Clinical Use.
AKT1S1 is a proline-rich substrate of AKT (MIM 164730) that binds 14-3-3 protein (see YWHAH, MIM 113508) when phosphorylated (Kovacina et al., 2003 [PubMed 12524439]).[supplied by OMIM, Mar 2008]
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Syncytiotrophoblasts)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Part of the mammalian target of rapamycin complex 1 (mTORC1) which contains MTOR, MLST8, RPTOR, AKT1S1/PRAS40 and DEPTOR. mTORC1 binds to and is inhibited by FKBP12-rapamycin. Interacts directly with RPTOR. The phosphorylated form interacts with 14-3-3 proteins.
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