CA9

Creative Biolabs offers innovative anti-CA9 products that target the highly selective carbonic anhydrase IX (CA9) enzyme, leveraging its unique expression profile in tumor tissues. Our anti-CA9 products are subjected to comprehensive testing and validation processes to guarantee their superior quality and dependability. This commitment to excellence empowers researchers to conduct critical studies with confidence.

CA9: An Appealing Target for Cancer Treatment

CA9, or Carbonic Anhydrase IX, is primarily located in the gastrointestinal system, where it plays an essential role in the regulation of acid production. This transmembrane glycoprotein features an active site located extracellularly and is classified as a tumor-associated isoenzyme of carbonic anhydrase. Research has shown that CA9 is significantly over-expressed in clear cell renal cell carcinoma (ccRCC) associated with VHL mutations, as well as in various hypoxic solid tumors. Due to its minimal presence in normal tissues combined with its heightened expression in numerous cancer types, CA9 has emerged as an attractive target for therapeutic interventions.

Alternative Names

Carbonic anhydrase 9; Carbonic anhydrase IX; CAIX; MN

Background

Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA IX is a transmembrane protein and is one of only two tumor-associated carbonic anhydrase isoenzymes known. It is expressed in all clear-cell renal cell carcinoma, but is not detected in normal kidneys or most other normal tissues. It may be involved in cell proliferation and transformation.

Anti-CA9 rAb Products

Creative Biolabs presents an extensive range of recombinant antibodies targeting CA9, engineered for optimal efficacy in research applications. These antibodies are crafted for high specificity and binding affinity, enabling reliable inhibition of CA9 activity. Moreover, we offer diverse antibody formats to meet various immunological investigations, empowering researchers to advance projects with efficacy and accuracy.

Table 1. Featured anti-CA9 recombinant antibody products at Creative Biolabs.

Creative Quality Control

Creative Biolabs is committed to delivering top-tier anti-CA9 recombinant antibodies, tailored for breakthroughs in immunological research. Our state-of-the-art laboratories employ rigorous quality control measures to ensure that each antibody exhibits outstanding specificity and efficacy. Furthermore, with a focus on continuous improvement, our expert team diligently enhances our production techniques, ensuring that our offerings remain at the forefront of biotechnological advancements.

Customer Reviews

Excellent

Do***e
Mouse Anti-CA9 Recombinant Antibody (clone 3E4) (MOB-0310CT)

I am highly impressed with the mouse anti-CA9 recombinant antibody from Creative Biolabs. The antibody exhibited excellent specificity and affinity, allowing for clear and distinct localization of CA9 in the sample. The fluorescence signals were bright and consistent, making it easy to visualize the target protein. The use of this antibody has further promoted the success of my project.

22/Jun/2022

Excellent

Da***l
Rabbit Anti-CA9 Recombinant Antibody (clone CBACN-083) (MRO-0229-CN)

The Rabbit Anti-CA9 Recombinant Antibody proved to be a game-changer for my IHC experiments. Its exceptional specificity and sensitivity delivered clear, strong staining, making CA9 expression easy to visualize. With minimal background noise, I was able to obtain precise results that have significantly advanced my tumor biology research.

2/Dec/2022

Excellent

Bo***b
Mouse Anti-CA9 Recombinant Antibody (clone AB-MN-21.5.2) (HPAB-1174WJ)

The Anti-CA9 Recombinant Antibody from Creative Biolabs proved to be a valuable asset in my ADCC assays. Its strong binding to CA9 and potent cytotoxic activity against target cells made it a reliable and effective tool for my research. The consistent and reproducible results I obtained solidified my confidence in this product.

13/May/2024

rAb Production

Our proprietary anti-CA9 recombinant antibody platform utilizes genetically engineered cells to produce high-quality, CA9-specific antibodies. This advanced system enables scalable and efficient manufacturing, ensuring a reliable supply for diverse uses.

Featured Anti-CA9 Recombinant Antibody Production Platforms
Fig.7 Milligram-scale anti-CA9 recombinant antibody production.

Fig.8 Gram-scale anti-CA9 recombinant antibody production.

rAb Modalities

Creative Biolabs delivers a wide range of high-quality anti-CA9 recombinant antibodies available in various formats to suit your specific research needs.

Fig.9 Full-length anti-CA9 recombinant antibody production and modalities.

CA9-Targeted Drug Information

Table 2. Public drug targeting CA9.

(Disclaimer: The information in this table is just for knowledge sharing and not for marketing or sales purposes.)

If you're in search of a trustworthy and high-performance anti-CA9 antibody, look no further. Reach out to us today to tailor a solution that meets your unique requirements.