CAMK2A

Antibody Magnetic Beads AbPlus Recombinant Antibody Products Formats

Anti-CAMK2A Recombinant Antibody Products

Rabbit Anti-CAMK2A Recombinant Antibody (clone CBACN-082) (MRO-0224-CN)
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IF, IHC
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Rabbit Anti-CAMK2A Recombinant Antibody (clone JM11-07) (MRO-0225-CN)
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IP, FC
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Mouse Anti-CAMK2A Recombinant Antibody (clone 5D9-G10-G8) (VS3-QX142)
- Derivation: Mouse
- Species Reactivity: Human, Mouse
- Type: Mouse IgG1
- Application: WB
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Mouse Anti-CAMK2A Recombinant Antibody (clone 2G1) (VS3-XY154)
- Species Reactivity: Rat
- Type: Mouse IgG1
- Application: WB, IP, IF
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Rabbit Anti-CAMK2A (pT286) Recombinant Antibody (clone R95-4J-2) (VS3-WK2085)
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IHC-P
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AbPlus™ Anti-CAMK2A Magnetic Beads (JM11-07) (VS-0424-XY39)
- Target: CAMK2A
- Target Species: Human, Mouse, Rat
- Application: IP, Protein Purification
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Mouse Anti-CAMK2A Recombinant Antibody (clone EML270) (MOB-0298CT)
- Species Reactivity: Human
- Type: Mouse IgG2b
- Application: IF, IP, WB
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Hi-Affi™ Rabbit Anti-CAMK2A Recombinant Antibody (clone DS447AB) (MOR-0447)
- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IP
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For Research Use Only. Not For Clinical Use.

CAMK2A (Calcium/Calmodulin Dependent Protein Kinase II Alpha) is a Protein Coding gene. Diseases associated with CAMK2A include Mental Retardation, Autosomal Dominant 53 and Alacrima, Achalasia, And Mental Retardation Syndrome. Among its related pathways are RET signaling and Salivary secretion. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and protein kinase activity. An important paralog of this gene is CAMK2D.

Protein class

Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets

Predicted location

Membrane

Single cell type specificity

Cell type enriched (Excitatory neurons)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (HaCaT, SCLC-21H, SuSa, U-87 MG)

Interaction

There are 4 genes encoding calcium/calmodulin-dependent protein kinase type II chains: CAMK2A, CAMK2B, CAMK2G and CAMK2D. The corresponding proteins assemble into homo- or heteromultimeric holoenzymes composed of 12 subunits with two hexameric rings stacked one on top of the other (PubMed:14722083, PubMed:29784083). Interacts with BAALC. Interacts with MPDZ. Interacts with SYN1. Interacts with CAMK2N2. Interacts with SYNGAP1. Interacts with SYNPO2 (By similarity). Interacts with SHANK3 (PubMed:28130356). Interacts with GRIN2B (PubMed:28130356). Interacts with CACNB2 (PubMed:28130356). Interacts with LRRC7 (PubMed:28130356). Interacts with GRM5 (PubMed:28130356). Interacts with DAGLA (via C-terminal); this interaction is enhanced by autophosphorylation of CAMK2A at Thr-286 (By similarity). Interacts with CAMK2N1; this interaction requires CAMK2A activation by Ca(2+) (By similarity).

Molecular function

Calmodulin-binding, Kinase, Serine/threonine-protein kinase, Transferase

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Related Signaling Pathways

cAMP Signaling Pathway