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MAP2
Anti-MAP2 Recombinant Antibody Products
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: WB, ELISA, ICC, IHC, IP
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- Mouse Anti-MAP2 Recombinant Antibody (clone 7D4) (MOB-0095F)
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- Species Reactivity: Human, Mouse, Rat
- Type: Mouse IgG
- Application: IHC-P, IF
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- Derivation: Mouse
- Species Reactivity: Human, Mouse
- Type: Mouse IgG2b
- Application: WB, IP, ICC
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- Mouse Anti-MAP2 Recombinant Antibody (clone 5B7) (VS3-XY1024)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB, FC
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For Research Use Only. Not For Clinical Use.
MAP2 encodes a protein that is involved in stabilizing microtubules in neurons. Microtubules are part of the cytoskeleton, and their stability is crucial for maintaining the shape and structure of cells, especially neurons. MAP2 plays an important role in neuronal differentiation, growth, and signaling. It is also implicated in neurodevelopmental disorders, such as Alzheimer's disease, as alterations in MAP2 expression can affect neuronal function and lead to neurodegeneration.
Protein class
FDA approved drug targets, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Group enriched (Excitatory neurons, Cone photoreceptor cells, Inhibitory neurons, Oligodendrocyte precursor cells, Rod photoreceptor cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (AF22, NTERA-2, SCLC-21H, SH-SY5Y)
Interaction
Interacts with KNDC1 (via KIND2); the interaction enhances MAP2 phosphorylation and localizes KNDC1 to dendrites. Interacts with DPYSL5 (PubMed:33894126).
Molecular function
Calmodulin-binding
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